scholarly journals Systematic review of associations between HLA and renal function

2021 ◽  
Author(s):  
Marcus Lowe ◽  
Steven Jervis ◽  
Antony Payton ◽  
Kay Poulton ◽  
Judith Worthington ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Function

scholarly journals Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e030596 ◽  
Author(s):  
Kathryn S Taylor ◽  
Julie Mclellan ◽  
Jan Y Verbakel ◽  
Jeffrey K Aronson ◽  
Daniel S Lasserson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Glycaemic Control ◽  
Citation Index ◽  
Antihypertensive Drugs ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Low Grade ◽  
All Cause Mortality

ObjectiveTo evaluate the effects of drug interventions that may modify the progression of chronic kidney disease (CKD) in adults with CKD stages 3 and 4.DesignSystematic review and meta-analysis.MethodsSearching MEDLINE, EMBASE, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, International Clinical Trials Registry Platform, Health Technology Assessment, Science Citation Index, Social Sciences Citation Index, Conference Proceedings Citation Index and Clinical Trials Register, from March 1999 to July 2018, we identified randomised controlled trials (RCTs) of drugs for hypertension, lipid modification, glycaemic control and sodium bicarbonate, compared with placebo, no drug or a drug from another class, in ≥40 adults with CKD stages 3 and/or 4, with at least 2 years of follow-up and reporting renal function (primary outcome), proteinuria, adverse events, maintenance dialysis, transplantation, cardiovascular events, cardiovascular mortality or all-cause mortality. Two reviewers independently screened citations and extracted data. For continuous outcomes, we used the ratio of means (ROM) at the end of the trial in random-effects meta-analyses. We assessed methodological quality with the Cochrane Risk of Bias Tool and confidence in the evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.ResultsWe included 35 RCTs and over 51 000 patients. Data were limited, and heterogeneity varied. Final renal function (estimated glomerular filtration rate) was 6% higher in those taking glycaemic control drugs (ROM 1.06, 95% CI 1.02 to 1.10, I2=0%, low GRADE confidence) and 4% higher in those taking lipid-modifying drugs (ROM 1.04, 95% CI 1.00 to 1.08, I2=88%, very low GRADE confidence). For RCTs of antihypertensive drugs, there were no significant differences in renal function. Treatment with lipid-modifying drugs led to a 36% reduction in cardiovascular disease and 26% reduction in all-cause mortality.ConclusionsGlycaemic control and lipid-modifying drugs may slow the progression of CKD, but we found no pooled evidence of benefit nor harm from antihypertensive drugs. However, given the data limitations, further research is needed to confirm these findings.PROSPERO registration numberCRD42015017501.

A Systematic Review of Renal Function Estimation Equations

2019 ◽  
Vol 5 (5) ◽  
pp. 359-376
Author(s):  
Nadia Z. Noormohamed ◽  
Wei Gao ◽  
Matthew L. Rizk
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Function Estimation ◽  
Estimation Equations

scholarly journals Role of Endourological Procedures (PCNL and URS) on Renal Function: a Systematic Review

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Thomas Reeves ◽  
Amelia Pietropaolo ◽  
Nariman Gadzhiev ◽  
Christian Seitz ◽  
Bhaskar K. Somani
Keyword(s):  
Systematic Review ◽  
Renal Function

Renal function evaluation in patients undergoing orthotopic bladder substitution: a systematic review of literature

2014 ◽  
Vol 114 (4) ◽  
pp. 484-495 ◽  
Author(s):  
Ahmed M. Harraz ◽  
Ahmed Mosbah ◽  
Ahmed El-Assmy ◽  
Hosam Gad ◽  
Atallah A. Shaaban
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Function Evaluation ◽  
Review Of Literature ◽  
Bladder Substitution

scholarly journals Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0163907 ◽  
Author(s):  
Kun Li ◽  
Jianan Zou ◽  
Zhibin Ye ◽  
Jianzhong Di ◽  
Xiaodong Han ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Renal Function ◽  
Meta Analysis ◽  
Obese Patients

scholarly journals Vitamin D Analogs Can Retard the Onset or Progression of Diabetic Kidney Disease: A Systematic Review

2021 ◽  
Vol 2 ◽  
Author(s):  
Samuel N. Uwaezuoke
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Renal Function ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Diabetic Kidney Disease ◽  
Cross Sectional ◽  
Vitamin D Analogs ◽  
Randomized Controlled ◽  
Cross Sectional Studies

IntroductionPrevious studies have shown that vitamin D analogs (such as paricalcitol) can reduce albuminuria in patients with diabetes mellitus and retard the progression of diabetic kidney disease (DKD). A recent systematic review reported significant improvement of renal function in patients with DKD who received vitamin D or its analogs. Study-driven data about their use in improving DKD outcomes have continued to accumulate over the years.AimThis paper aims to systematically review the contemporary evidence about the effectiveness of vitamin D analogs in retarding the onset or progression of DKD.MethodsWith appropriate descriptors, two electronic databases (PubMed and Google Scholar) were searched for articles published between 2015 and 2021 in the English language. Primary studies that fulfilled the inclusion criteria were selected; their titles and abstracts were screened, and duplicates were removed. Relevant data were retrieved from the final selected studies using a preconceived data-extraction form.ResultsA total of eight studies (three randomized-controlled trials, one prospective study, and four cross-sectional studies) were reviewed. A total of 6,243 participants were investigated in the eight studies and comprised young adults, middle-aged adults, and the elderly with a male-gender predominance. One randomized controlled trial reported that paricalcitol significantly improved renal function in type 1 diabetes patients with renal impairment when combined with renin-angiotensin-aldosterone system (RAAS) blockers. A strong correlation between vitamin D deficiency and DKD risk was noted in the majority of the cross-sectional studies. High doses of cholecalciferol (4,000 or 10,000 IU/day), given early in DKD, significantly reduced disease prevalence.ConclusionParicalcitol may retard the onset or progression of DKD, especially if administered in combination with RAAS blockers. The association of vitamin D deficiency with DKD risk also supports this therapeutic effect. Future systematic reviews are still needed to strengthen the current evidence on therapeutic benefit of vitamin D or its analogs in DKD.

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