A comment on estimating HLA haplotype frequencies from homozygous individuals

2021 ◽  
Author(s):  
José Manuel Nunes
Keyword(s):  
Haplotype Frequencies

scholarly journals Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sabrina Samad Shoily ◽  
Tamim Ahsan ◽  
Kaniz Fatema ◽  
Abu Ashfaqur Sajib
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Genetic Variants ◽  
Nucleotide Polymorphisms ◽  
Differential Distribution ◽  
East Asians ◽  
Single Nucleotide ◽  
Common Genetic Variants ◽  
Haplotype Frequencies ◽  
Variant Alleles

AbstractDiabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre- or post-existent with complications such as cardiovascular disease, hypertension, inflammation, chronic kidney disease, diabetic retino- and nephropathies. However, the frequencies of these co-morbidities vary among individuals and across populations. It is, therefore, not unlikely that certain genetic variants might commonly contribute to these conditions. Here, we identified four single nucleotide polymorphisms (rs5186, rs1800795, rs1799983 and rs1800629 in AGTR1, IL6, NOS3 and TNFA genes, respectively) to be commonly associated with each of these conditions. We explored their possible interplay in diabetes and associated complications. The variant allele and haplotype frequencies at these polymorphic loci vary among different super-populations (African, European, admixed Americans, South and East Asians). The variant alleles are particularly highly prevalent in different European and admixed American populations. Differential distribution of these variants in different ethnic groups suggests that certain drugs might be more effective in selective populations rather than all. Therefore, population specific genetic architectures should be considered before considering a drug for these conditions.

HLA-DR phenotype and HLA-B,DR haplotype frequencies in 704 unrelated Danes

1981 ◽  
Vol 18 (4) ◽  
pp. 270-275 ◽  
Author(s):  
Bodil K. Jakobsen ◽  
N. Morling ◽  
P. Platz ◽  
L. P. Ryder ◽  
M. Thomsen ◽  
...  
Keyword(s):  
Hla Dr ◽  
Haplotype Frequencies

Lactase haplotype frequencies in Caucasians: association with the lactase persistence/non-persistence polymorphism

1998 ◽  
Vol 62 (3) ◽  
pp. 215-223 ◽  
Author(s):  
C. B. HARVEY ◽  
E. J. HOLLOX ◽  
M. POULTER ◽  
Y. WANG ◽  
M. ROSSI ◽  
...  
Keyword(s):  
Lactase Persistence ◽  
Haplotype Frequencies

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in the Serbian population

2014 ◽  
Vol 75 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Zorana Andric ◽  
Dusan Popadic ◽  
Barbara Jovanovic ◽  
Ivana Jaglicic ◽  
Svetlana Bojic ◽  
...  
Keyword(s):  
Haplotype Frequencies ◽  
Dqb1 Allele
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