CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population‐based cohort study

2021 ◽  
Author(s):  
Suelen Cristina Lima ◽  
Isaura Isabelle Fonseca Gomes da Silva ◽  
Denise de Queiroga Nascimento ◽  
Ronald Rodrigues Moura ◽  
Matheus da Silva Mesquita ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Cohort Study ◽  
Gene Polymorphism ◽  
Lupus Erythematosus ◽  
Population Based ◽  
Systemic Lupus

Risk of systemic lupus erythematosus in patients with endometriosis: A nationwide population-based cohort study

2020 ◽  
Vol 302 (5) ◽  
pp. 1197-1203
Author(s):  
Ya-Hui Lin ◽  
Yu-Cih Yang ◽  
Shih-Fen Chen ◽  
Chung-Y Hsu ◽  
Yu-Chih Shen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cohort Study ◽  
Lupus Erythematosus ◽  
Population Based ◽  
Systemic Lupus

Reproductive Factors and Risk of Systemic Lupus Erythematosus: Nationwide Cohort Study in Denmark

2009 ◽  
Vol 36 (9) ◽  
pp. 1903-1909 ◽  
Author(s):  
CONSTANCE J. ULFF-MØLLER ◽  
KRISTIAN T. JØRGENSEN ◽  
BO V. PEDERSEN ◽  
NETE M. NIELSEN ◽  
MORTEN FRISCH
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cohort Study ◽  
Lupus Erythematosus ◽  
Lower Risk ◽  
Reproductive Factors ◽  
Population Based ◽  
Spontaneous Abortions ◽  
Contributing Factors ◽  
Systemic Lupus ◽  
Nulliparous Women

Objective.The female predominance in systemic lupus erythematosus (SLE) suggests the possible involvement of reproductive factors in its etiology. We evaluated the relationship between parity and pregnancy losses and subsequent risk of SLE in a population-based cohort study.Methods.We followed 4.4 million Danes aged 15–69 years for first inpatient hospitalizations for SLE between 1977 and 2004. As measures of relative risk, we used Poisson regression-derived hospitalization rate ratios (RR) with 95% confidence intervals (CI) for cohort members with different reproductive histories.Results.Overall, 1614 women and 274 men were hospitalized with SLE during 88.9 million person-years of followup. Number of children was unrelated to SLE risk in men, but women with at least one liveborn child were at lower risk than nulliparous women (RR 0.74; 95% CI 0.64–0.86), and women with 2 or more children were at lower risk than 1-child mothers. Recurrent idiopathic pregnancy losses, including spontaneous abortions, missed abortions, and stillbirths, were associated with markedly increased SLE risk (RR 3.50; 95% CI 2.38–4.96, for 2+ vs none; p < 0.001).Conclusion.Nulliparous women, 1-child mothers, and women who experience spontaneous abortions, missed abortions, or stillbirths are at increased SLE risk. Theoretically, immunological processes involved in subfertility or idiopathic pregnancy losses might act as initiating or contributing factors in some cases of SLE. However, considering the well established excess of pregnancy complications in women with established SLE, the observed associations more likely reflect the effect of subclinical immunological processes in women destined to develop SLE.

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