scholarly journals Human leucocyte antigen class I and II imputation in a multiracial population

2016 ◽  
Vol 43 (6) ◽  
pp. 369-375 ◽  
Author(s):  
M. H. Kuniholm ◽  
X. Xie ◽  
K. Anastos ◽  
X. Xue ◽  
L. Reimers ◽  
...  
Keyword(s):  
Human Leucocyte Antigen ◽  
Class I ◽  
Human Leucocyte Antigen Class

scholarly journals CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity

2012 ◽  
Vol 170 (1) ◽  
pp. 57-65 ◽  
Author(s):  
J. R. F. Abreu ◽  
S. Martina ◽  
A. A. Verrijn Stuart ◽  
Y. E. Fillié ◽  
K. L. M. C. Franken ◽  
...  
Keyword(s):  
T Cell ◽  
Binding Affinity ◽  
Human Leucocyte Antigen ◽  
Cd8 T Cell ◽  
Class I ◽  
Human Leucocyte Antigen Class

Serum-soluble human leucocyte antigen class I and class II concentrations as an alternative diagnostic test for determining immune indices required for normal pregnancies

2001 ◽  
Vol 13 (6) ◽  
pp. 427 ◽  
Author(s):  
Simon Vassiliadis ◽  
Michael Paflis ◽  
Irene Athanassakis
Keyword(s):  
Human Leucocyte Antigen ◽  
Mixed Lymphocyte Reaction ◽  
Hla Class I ◽  
First Trimester ◽  
Class Ii ◽  
Class I ◽  
Second Trimester ◽  
Human Leucocyte Antigen Class ◽  
Soluble Hla ◽  
Soluble Class

The levels of maternal immunostimulation (required throughout the gestation period) and immunosuppression (needed from the 8th week to labour), as assessed by the mixed lymphocyte reaction (MLR), have been successfully correlated with the outcome of pregnancy. Our laboratory has recently reported that serum-soluble human leucocyte antigen (HLA) class I and II concentrations can be predictive for successful pregnancy outcome. In fact, there is a direct correlation between soluble class II concentrations and maternal immunostimulation because, as expected, these serum HLA concentrations are augmented in the first and second trimester of pregnancy and remain stable thereafter. By the same token, serum HLA class I concentrations are low during the first trimester, correlating with the required absence of immunosuppression, whereas they increase in subsequent trimesters as suppression becomes desirable for counteracting the maternal stimulation, which may otherwise become dangerous to the fetus. In this study, we present biological and statistical evidence that both states of maternal immunostimulation and immunosuppression, reflected by serum soluble HLA class II and class I antigens, do correlate with results obtained by standard MLR and can be predictive of pregnancy failure. The establishment of statistically significant correlations renders the measurement of soluble HLA a reliable test for determining the immunological status of the gestating woman. The unambiguous advantage of such an approach is that soluble HLA testing will no longer require the 1 week delay necessary to obtain MLR results, a period occasionally crucial for applying treatment to women whose immunological indices call for immediate therapeutic intervention.

Serum soluble human leucocyte antigen class I in paediatric liver transplantation with live, related donors

1997 ◽  
Vol 5 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Masao Hagihara ◽  
Batmunkh Munkhbat ◽  
Nobuyuki Kanai ◽  
Tatsuo Shimura ◽  
Tetsuya Kiuchi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Human Leucocyte Antigen ◽  
Class I ◽  
Human Leucocyte Antigen Class ◽  
Paediatric Liver Transplantation
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