Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand interactor

2015 ◽  
Vol 42 (4) ◽  
pp. 239-253 ◽  
Author(s):  
H. D. Sathkumara ◽  
N. R. De Silva ◽  
S. Handunnetti ◽  
A. D. De Silva
Keyword(s):  
Common Variable Immunodeficiency ◽  
Common Variable

Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency

2007 ◽  
Vol 39 (4) ◽  
pp. 430-431 ◽  
Author(s):  
Emanuela Castigli ◽  
Stephen Wilson ◽  
Lilit Garibyan ◽  
Rima Rachid ◽  
Francisco Bonilla ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Iga Deficiency ◽  
Selective Iga Deficiency ◽  
Coding Variants ◽  
Common Variable

scholarly journals Enhanced apoptosis of T cells in common variable immunodeficiency (CVID): role of defective CD28 co-stimulation

2000 ◽  
Vol 120 (3) ◽  
pp. 503-511 ◽  
Author(s):  
M. Di Renzo ◽  
Z. Zhou ◽  
I. George ◽  
K. Becker ◽  
C. Cunningham-Rundles
Keyword(s):  
T Cells ◽  
Common Variable Immunodeficiency ◽  
Common Variable

The role of toll-like receptors in B-cell development and immunopathogenesis of common variable immunodeficiency

2015 ◽  
Vol 12 (2) ◽  
pp. 195-207 ◽  
Author(s):  
Laleh Sharifi ◽  
Abbas Mirshafiey ◽  
Nima Rezaei ◽  
Gholamreza Azizi ◽  
Kabir Magaji Hamid ◽  
...  
Keyword(s):  
B Cell ◽  
Common Variable Immunodeficiency ◽  
Cell Development ◽  
B Cell Development ◽  
Toll Like Receptors ◽  
Common Variable

scholarly journals Recurrent Campylobacter jejuni Infection in an Immunodeficient Patient Treated with Repeated Faecal Microbiota Transplant (FMT)—A Case Report

2022 ◽  
Vol 14 (1) ◽  
pp. 56-62
Author(s):  
Blair Merrick ◽  
Aravind Gokul Tamilarasan ◽  
Raphael Luber ◽  
Patrick F. K. Yong ◽  
Kuldeep Cheent ◽  
...  
Keyword(s):  
Case Report ◽  
Campylobacter Jejuni ◽  
Successful Treatment ◽  
Common Variable Immunodeficiency ◽  
Immunoglobulin Therapy ◽  
Faecal Microbiota ◽  
Limited Evidence ◽  
Campylobacter Infection ◽  
Common Variable

There is limited evidence to guide successful treatment of recurrent Campylobacter infection in patients with common variable immunodeficiency (CVID) already managed on regular immunoglobulin therapy. The role of faecal microbiota transplant (FMT) is uncertain. We report a case of recurrent Campylobacter jejuni infection in a patient with CVID treated with repeated FMT with 18 months of symptom resolution prior to relapse.

Acute Cerebellitis and Myeloradiculitis Associated With SARS-CoV-2 Infection in Common Variable Immunodeficiency—A Case Report

2021 ◽  
pp. 194187442110502
Author(s):  
Hernan Nicolas Lemus ◽  
Miryam Alkayyali ◽  
Eonjung Kim ◽  
Charlotte Cunnigham-Rundles ◽  
Dewitt Pyburn ◽  
...  
Keyword(s):  
Immune System ◽  
Common Variable Immunodeficiency ◽  
Clinical Course ◽  
Adaptive Immune System ◽  
Complex Interaction ◽  
Cns Injury ◽  
Adaptive Immune ◽  
The Brain ◽  
Common Variable

The role of the adaptive immune system in mediating COVID-19 is largely unknown. Therefore, it is difficult to predict the clinical course in patients with common variable immunodeficiency (CVID), a disease characterized by dysfunctional lymphocytes and impaired antibody production. We report a case of SARS-CoV-2 infection presenting as isolated neurological symptoms in a patient with CVID. The patient subsequently improved following steroids, intravenous immunoglobulin, and convalescent plasma (CP). The latter has been shown to be safe and efficacious in treating COVID-19 in patients with primary immunodeficiency. Recent data suggest that the mechanism of CNS injury in COVID-19 may be due to immunological dysregulation rather than direct viral-mediated injury. This case exemplifies the complex interaction between the brain, the immune system, and the SARS-CoV-2 virus.

THU0017 The Role of HLA DQ2 and DQ8 in Dissecting Celiac-Like Disease in Common Variable Immunodeficiency

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A170.1-A170
Author(s):  
J. Thiel ◽  
F. Emmerich ◽  
M. Neagu ◽  
U. Salzer ◽  
R. E. Voll ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Common Variable ◽  
Hla Dq2

scholarly journals Genetic defects and the role of helper T-cells in the pathogenesis of common variable immunodeficiency

2014 ◽  
Vol 3 (1) ◽  
pp. 2 ◽  
Author(s):  
Roya Sherkat ◽  
Vida Homayouni ◽  
Rahim Farahani ◽  
Reza Yazdani ◽  
MazdakGanjalikhani Hakemi
Keyword(s):  
T Cells ◽  
Common Variable Immunodeficiency ◽  
Helper T Cells ◽  
Genetic Defects ◽  
Common Variable

scholarly journals Chronic meningococcaemia and immunoglobulin A deficiency

2010 ◽  
Vol 59 (11) ◽  
pp. 1375-1378 ◽  
Author(s):  
Arnaud Theulin ◽  
Murielle Rondeau-Lutz ◽  
Cornelia Kuhnert ◽  
Julien Boileau ◽  
Jean-Christophe Weber
Keyword(s):  
B Cells ◽  
Neisseria Meningitidis ◽  
Common Variable Immunodeficiency ◽  
Clinical Presentation ◽  
Immunoglobulin A ◽  
Iga Deficiency ◽  
Memory B Cells ◽  
Igm Deficiency ◽  
Common Variable

Chronic meningococcaemia is an unusual clinical presentation of Neisseria meningitidis infection. We describe the case of a patient, who presented with total IgA deficiency and partial IgM deficiency with a low switched memory B cells count, suggestive of a borderline form of common variable immunodeficiency (CVID). The role of IgA in the protection against Neisseria meningitidis, and the link between IgA deficiency and CVID are discussed.

Limited role of interferon-kappa ( IFNK ) truncating mutations in common variable immunodeficiency

Cytokine ◽  
2017 ◽  
Vol 96 ◽  
pp. 71-74
Author(s):  
Faranaz Atschekzei ◽  
Thilo Dörk ◽  
Peter Schürmann ◽  
Robert Geffers ◽  
Torsten Witte ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Limited Role ◽  
Common Variable
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