ERAP1 variants are associated with ankylosing spondylitis in East Asian population: a new Chinese case-control study and meta-analysis of published series

2015 ◽  
Vol 42 (3) ◽  
pp. 168-173 ◽  
Author(s):  
C. Chen ◽  
X. Zhang
Keyword(s):  
Ankylosing Spondylitis ◽  
Case Control Study ◽  
Meta Analysis ◽  
East Asian ◽  
Asian Population ◽  
Case Control ◽  
East Asian Population ◽  
Chinese Case ◽  
Control Study

scholarly journals Case-control study of hypertension and Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuen-Fann Ng ◽  
Ebonne Ng ◽  
Ee-Wei Lim ◽  
Kumar M. Prakash ◽  
Louis C. S. Tan ◽  
...  
Keyword(s):  
Case Control Study ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Case Control Studies ◽  
Matched Case ◽  
And Gender ◽  
Chinese Subjects ◽  
Matched Case Control Study ◽  
Control Study

AbstractWe evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46–2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66–0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.

scholarly journals Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis

2017 ◽  
Vol 33 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Xianhong Feng ◽  
Jingdong Wang ◽  
Xiuli Gu ◽  
Jingli Zhang ◽  
Xiaolin Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Smoking Status ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Control Study

Purpose: To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis. Methods: The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing. Results: The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding. However, data from a meta-analysis in the Asian population revealed a significant association between -283T>C and lung cancer risk in the allelic model (C vs. T: odds ratio [OR] = 1.28, 95% confidence interval [CI], 1.06-1.55, p = 0.01) and two genetic models (CC vs. TC: OR = 1.29, 95% CI, 1.04-1.59, p = 0.02; CC vs. TC + TT: OR = 1.30, 95% CI, 1.06-1.60, p = 0.01). Conclusions: These results provided evidence that the DNMT3B -283T>C polymorphism might significantly contribute to the lung cancer risk in the Asian population, but not the gastric cancer risk in the Chinese population.

scholarly journals Trans-Ethnical Shift of the Risk Genotype in the CETP I405V with Longevity: A Chinese Case-Control Study and Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72537 ◽  
Author(s):  
Liang Sun ◽  
Cai-you Hu ◽  
Xiao-hong Shi ◽  
Chen-guang Zheng ◽  
Ze-zhi Huang ◽  
...  
Keyword(s):  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Risk Genotype ◽  
Chinese Case ◽  
Control Study

scholarly journals Association of the MC4R V103I Polymorphism With Obesity: A Chinese Case-control Study and Meta-analysis in 55,195 Individuals

Obesity ◽  
2010 ◽  
Vol 18 (3) ◽  
pp. 573-579 ◽  
Author(s):  
Du Wang ◽  
Jun Ma ◽  
Su Zhang ◽  
Anke Hinney ◽  
Johannes Hebebrand ◽  
...  
Keyword(s):  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Chinese Case ◽  
Control Study
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