HLA class III genes involvement in Kawasaki disease: a case-control study in Caucasian population

2013 ◽  
Vol 41 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Elisa Maggioli ◽  
Chiara Boiocchi ◽  
Michele Zorzetto ◽  
Savina Mannarino ◽  
Grazia Bossi ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Case Control Study ◽  
Case Control ◽  
Caucasian Population ◽  
Class Iii ◽  
Class Iii Genes ◽  
Control Study

scholarly journals Cognitive development of children with Kawasaki disease and the parenting stress of their caregivers in Taiwan: a case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e042996
Author(s):  
Liang-Jen Wang ◽  
Zi-Yu Tsai ◽  
Ling-Sai Chang ◽  
Ho-Chang Kuo
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Parenting Stress ◽  
Case Control Study ◽  
Short Form ◽  
Case Control ◽  
Stress Index ◽  
Secondary Outcome ◽  
Healthy Children ◽  
Control Study

ObjectiveKawasaki disease (KD) is an acute form of febrile vasculitis that occurs in early childhood. The multisystemic vasculitis common in patients with KD may influence blood perfusion in the brain, and thus caregivers of children with KD may feel stress with regard to caring for them. Intravenous immunoglobulin (IVIG) infusion is the standard treatment for acute KD, and the most serious complication of KD is coronary artery aneurysms (coronary artery lesion (CAL)). This study aimed to investigate the relationships between KD heterogeneity and the risk of patients’ cognitive impairment or caregivers’ parenting stress.DesignA case–control study with consecutive sampling.SettingA medical centre (Kaohsiung Chang Gung Memorial Hospital, Taiwan).ParticipantsThis study consisted of 176 patients with KD (mean age: 5.5 years, 60.8% boys) and 85 healthy children (mean age: 6.4 years, 54.1% boys).Primary and secondary outcome measuresBased on the children’s age, each patient with KD and control subject was administered an assessment using the Mullen Scales of Early Learning or the Wechsler Intelligence Scale, and parenting function of their caregivers was assessed using the Parenting Stress Index (PSI)-Short Form.ResultsWe observed no significant differences in any developmental index, cognitive function or parenting stress between patients with KD and controls. Among the children with KD, IVIG administration nor CAL was associated with children’s cognitive scores. However, the caregivers of patients who had CAL suffered from greater PSI total scores than those of patients without CAL. Furthermore, the caregivers who had education levels of a master’s degree or above showed less parenting stress than those who had an education level of college or lower.ConclusionCaregivers’ education is associated to parenting stress, and caregivers of patients with KD who developed CAL may feel stress about the unpredictable sequela caused by CAL for their children. Such caregivers may require support to fulfil their parenting roles.

scholarly journals IL-10 Promoter Genetic Polymorphisms and Risk of Kawasaki Disease in Taiwan

2011 ◽  
Vol 30 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Kai-Sheng Hsieh ◽  
Tsung-Jen Lai ◽  
Yu-Tung Hwang ◽  
Ming-Wei Lin ◽  
Ken-Pen Weng ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Case Control Study ◽  
Serum Levels ◽  
High Plasma ◽  
Case Control ◽  
Healthy Children ◽  
Increased Risk ◽  
Family Based ◽  
Control Study

Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (−1082, −819, and −592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci −819 T > C and −592 A > C for KD cases was observed (Ppermutation= 0.029 and Ppermutation= 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p= 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090–2.443; Ppermutation= 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. {The haplotype CC (−819, −592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987–1.797;p= 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant,p= 0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and −592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study.

scholarly journals Atopic Asthma as an Unrecognized Risk Factor for Kawasaki Disease: A Population-Based Case-Control Study

2019 ◽  
Vol 143 (2) ◽  
pp. AB106
Author(s):  
Bong Seok Choi ◽  
Editt Nikoyan ◽  
Chung-Il Wi ◽  
Katherine S. King ◽  
Euijung Ryu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Kawasaki Disease ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Atopic Asthma ◽  
Control Study

Kawasaki Disease in a Pediatric Intensive Care Unit: A Case-Control Study

PEDIATRICS ◽  
2008 ◽  
Vol 122 (4) ◽  
pp. e786-e790 ◽  
Author(s):  
Samuel R. Dominguez ◽  
Kevin Friedman ◽  
Ryan Seewald ◽  
Marsha S. Anderson ◽  
Lisa Willis ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Kawasaki Disease ◽  
Pediatric Intensive Care Unit ◽  
Case Control Study ◽  
Pediatric Intensive Care ◽  
Case Control ◽  
Control Study

Cardiovascular Risk After Kawasaki Disease - Findings From an Australian Case-Control Study

2018 ◽  
Vol 27 (1) ◽  
pp. 6-8
Author(s):  
Katherine Y.H. Chen ◽  
Nigel Curtis ◽  
Michael Cheung ◽  
David Burgner
Keyword(s):  
Cardiovascular Risk ◽  
Kawasaki Disease ◽  
Case Control Study ◽  
Case Control ◽  
Australian Case ◽  
Control Study

scholarly journals A Genetic Variant rs1801274 in FCGR2A as a Potential Risk Marker for Kawasaki Disease: A Case-Control Study and Meta-Analysis

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103329 ◽  
Author(s):  
Jiayu Duan ◽  
Jiao Lou ◽  
Qing Zhang ◽  
Juntao Ke ◽  
Yanqi Qi ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Potential Risk ◽  
Genetic Variant ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Risk Marker ◽  
Control Study

scholarly journals Three-Dimensional Outcome Assessments of Surgical Correction in Cleft and Noncleft Patients with Class III Skeletal Relation: A Case-Control Study

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Te-Ju Wu ◽  
Cheng-Chun Wu ◽  
Chi-Yu Tsai ◽  
Yi-Hao Lee ◽  
Yu-Jen Chang ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
Vertical Movement ◽  
Case Control ◽  
Class Iii ◽  
Vertical Movements ◽  
Receiver Operating Characteristic Curves ◽  
Control Study

Background. The orthognathic strategies to treat patients with a concave profile but different tissue conditions remain controversial. The aim of this case-control study was to investigate the outcome predictability of orthognathic surgery in cleft lip and palate (CLP) patients and matched controls. Methods. Fifty consecutive CLP and 45 matched non-CLP patients who received whole-piece Le Fort I and bilateral sagittal split osteotomy to correct class III skeletal relations were enrolled. The outcome discrepancies (ODs) from simulations among all groups were evaluated with consideration of the possible influences from planned surgical movements (PSM). Receiver operating characteristic curves were used to determine threshold values of PSMs that yielded clinically relevant OD. Results. Unilateral CLP (UCLP) patients had comparable postsurgical OD to non-CLP patients in both jaws, whereas bilateral CLP (BCLP) patients had greater deviations from predicted results. Vertical movement of the A − point > 1.33   mm and yaw   correction > 1.65 ° in the BCLP patients was associated with clinically relevant maxillary OD. Conclusions. The OGS outcomes of BCLP patients were less predictable than those of the UCLP and noncleft patients. Vertical movements of the A − point > 1.33   mm and yaw   correction > 1.65 ° in BCLP patients increased OD to a clinically relevant extent.

Association between breastfeeding and Kawasaki disease: a case–control study

2019 ◽  
Vol 179 (3) ◽  
pp. 447-453
Author(s):  
Shun Wang ◽  
Dan Xiang ◽  
Congcong Fang ◽  
Baozhen Yao
Keyword(s):  
Kawasaki Disease ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
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