Purification and identification of novel antibacterial peptides isolated from Tualang honey

2021 ◽  
Author(s):  
Mohamed Mustafa Aween ◽  
Zaiton Hassan ◽  
Belal J. Muhialdin
Keyword(s):  
Antibacterial Peptides ◽  
Tualang Honey

scholarly journals The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

2021 ◽  
Author(s):  
Samantha J. Bann ◽  
Ross D. Ballantine ◽  
Stephen A. Cochrane
Keyword(s):  
Gram Negative Bacteria ◽  
Antibacterial Peptides ◽  
Gram Negative ◽  
Non Ribosomal Peptides

Tridecaptins are a re-emerging class of non-ribosomal antibacterial peptides (NRAPs) with potent activity against highly problematic strains of Gram-negative bacteria.

Walking the fine line between intracellular and membrane activities of antibacterial peptides

2003 ◽  
Vol 10 (5-6) ◽  
pp. 463-473 ◽  
Author(s):  
Molly A. Bower ◽  
Mare Cudic ◽  
William Campbell ◽  
John D. Wade ◽  
Laszlo Otvos
Keyword(s):  
Antibacterial Peptides ◽  
Fine Line

scholarly journals Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Nik Muhd Khuzaimi Nik Man ◽  
Rosline Hassan ◽  
Cheng Yong Ang ◽  
Abu Dzarr Abdullah ◽  
Muhammad Amiro Rasheeq Mohd Radzi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mononuclear Cell ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
Leukemia Cell ◽  
Chronic Leukemia ◽  
Human Mononuclear Cell ◽  
Leukemia Cell Lines ◽  
Antileukemic Effect ◽  
Tualang Honey

Complementary medicine using natural product as antitumor is on the rise. Much research has been performed on Tualang Honey and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several cancer models such as human osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231), and cervical (HeLa) cancer cell lines. To date, there was limited study on antileukemic properties of Tualang (Koompassia excelsa) Honey. The aim of this study was to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines. Leukemia cell lines (K562 and MV4-11) and human mononuclear cell isolated from peripheral blood were grown in RPM1 1640 culture medium. The cells were incubated with increasing concentrations of Tualang Honey. After incubation, the evaluation of viability and apoptosis was performed. The morphological changes of leukemia cells were the presence of cytoplasmic blebs followed by apoptotic bodies and round shape of cells. IC50against K562 and MV4-11 was determined. Tualang Honey gave 53.9% and 50.6% apoptosis activity on K562 and MV4-11, respectively, while on human mononuclear cell it was 37.4%. Tualang Honey has the apoptosis-inducing ability for acute and chronic myeloid leukemia (K562 and MV4-11) cell lines.

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