Distant metastases from an originally diagnosed melanoma in situ primary tumor

2021 ◽  
Author(s):  
Shoshana Zhang ◽  
Kristan Schiele ◽  
Clay J. Cockerell ◽  
Roopal Bhatt
Keyword(s):  
Primary Tumor ◽  
Distant Metastases ◽  
Melanoma In Situ

scholarly journals Comparación entre los melanomas de cabeza y cuello con los de tronco y extremidades

2020 ◽  
Vol 112 (2) ◽  
pp. 157-164
Author(s):  
Silvina Verna ◽  
◽  
Gisela Coliva ◽  
Matías Norte ◽  
Fernando Dip ◽  
...  
Keyword(s):  
Head And Neck ◽  
Multidisciplinary Approach ◽  
Distant Metastases ◽  
Primary Lesion ◽  
Primary Defect ◽  
Melanoma In Situ ◽  
Clinical Records ◽  
Age Range

Background: Head and neck melanomas (HNMs) have been associated with prognostic factors different from those on other locations. Objective: The goal of the present study was to compare the demographic and clinical characteristics and the outcomes of surgical treatment between patients with HNM and those with trunk and extremity melanoma (TEM). Material and methods: The clinical records of patients undergoing surgery for melanoma between October 2014 and April 2018 were retrospectively reviewed. Fifteen patients (22.3%) had HNM and 52 (77.7) presented TEM. Results: There were no differences in age between both groups (63.8 ± 21.1 versus 58.5 ± 16), but there was a trend toward higher percentage of men in the HNM group (80% versus 61.3%). Patients with HNM had lower tumor thickness than those with TEM (2.07 versus 5.5 mm), higher incidence of melanoma in situ [5 (33.3%) versus 8 (15.3%)]; lymph node resection was more common (33% versus 25%) as well as reconstruction of the primary defect with local and musculocutaneous flaps. During follow-up, two patients in the HNM group developed local recurrences that were excised and three presented distant metastases in the lung, small bowel and abdomen and finally died due to the disease. In the TEM group, one patient had local recurrence and five died due to systemic metastases. The sample size was not sufficient to assess statistically significant differences. Conclusion: Head and neck melanomas occur in a wide age range and stages and has some clinical differences with TEM. The defects produced after the excision of the primary lesion often require more complex procedures and should be managed with a multidisciplinary approach.

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