Uncoupling protein 2 and dynamin‐related protein 1 mRNA expressions as genetic markers for plaque psoriasis

2021 ◽  
Author(s):  
Wafaa A. Shehata ◽  
Mostafa A. Hammam ◽  
Rasha S. Enany ◽  
Sally M. El‐Hefnawy ◽  
Shimaa Abdelsattar
Keyword(s):  
Genetic Markers ◽  
Plaque Psoriasis ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Related Protein

scholarly journals Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ji Hye Lim ◽  
Mi Mi Ko ◽  
Hoyoung Lee ◽  
Ho Yeon Go ◽  
Tae-Woong Moon ◽  
...  
Keyword(s):  
Uncoupling Protein ◽  
Mitochondrial Protein ◽  
Diagnostic System ◽  
Cell Types ◽  
Pattern Identification ◽  
Uncoupling Protein 2 ◽  
Stroke Patients ◽  
Standard Pattern ◽  
Yin Deficiency ◽  
Predictive Parameters

Uncoupling protein 2 (UCP2), a mitochondrial protein present in many organs and cell types, is known to dissipate the proton gradient formed by the electron transport chain. Its function is correlated with predictive parameters, such as obesity, diabetes, and metabolic syndromes. We analyzed the distribution of UCP2 polymorphisms in stroke patients diagnosed with one of the following four stroke subtypes based on the TKM standard pattern identification (PI): Qi-deficiency (QD), Dampness and Phlegm (D&P), Yin-deficiency (YD), and Fire and Heat (F&D). We studied a total of 1,786 stroke patients (397/QD, 645/D&P, 223/YD, and 522/F&D, 586/normal). Genotyping for the G-1957A, G-866A and A55V UCP2 polymorphisms was performed using the TaqMan. G-866A and A55V were significantly associated with the D&P and H&F subtypes. The frequency of subjects with the A allele of G-866A was significantly lower than the frequency of subjects with the GG type. The A55V polymorphism was also shown similar effect with G-866A in the dominant model. In contrast, no SNPs were shown to be associated with the QD or YD subtypes in this study. These results showed that the G-866A and A55V UCP2 polymorphisms may be genetic factors for specific PI types among Korean stroke patients.

Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene

Life Sciences ◽  
1998 ◽  
Vol 64 (3) ◽  
pp. PL41-PL50 ◽  
Author(s):  
N. Tu ◽  
H. Chen ◽  
U. Winnikes ◽  
I. Reinert ◽  
G. Marmann ◽  
...  
Keyword(s):  
Structural Organization ◽  
Mutational Analysis ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2

Increased expression of uncoupling protein 2 in HepG2 cells attenuates oxidative damage and apoptosis

2005 ◽  
Vol 25 (4) ◽  
pp. 880-887 ◽  
Author(s):  
Peter Collins ◽  
Catherine Jones ◽  
Sarah Choudhury ◽  
Leonard Damelin ◽  
Humphrey Hodgson
Keyword(s):  
Oxidative Damage ◽  
Hepg2 Cells ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2

scholarly journals Mechanism of uncoupling protein 2-mediated myocardial injury in hypothermic preserved rat hearts

2016 ◽  
Vol 14 (2) ◽  
pp. 1857-1864 ◽  
Author(s):  
Gai-Ge Chen ◽  
Jin-Bin Yan ◽  
Xu-Ming Wang ◽  
Ming-Zhi Zheng ◽  
Jian-Ping Jiang ◽  
...  
Keyword(s):  
Myocardial Injury ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Rat Hearts
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