Anti‐aging effect of an oral disintegrating collagen film: a prospective, single‐arm study

2021 ◽  
Author(s):  
Young In Lee ◽  
Sang Gyu Lee ◽  
Eunbin Kim ◽  
Inhee Jung ◽  
Jangmi Suk ◽  
...  
Keyword(s):  
Aging Effect ◽  
Collagen Film

RESEARCH ON PREPARATION OF  GAMMA ORYZANOL ANTI-AGING CREAM

2017 ◽  
pp. 15-21
Author(s):  
Thi Minh Nguyet Le ◽  
Thi Kim Lien Phan
Keyword(s):  
Product Quality ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Aging Effect ◽  
Triterpene Alcohols ◽  
Beneficial Effects ◽  
Long Time ◽  
Formulation Parameters ◽  
Rice Water ◽  
Gamma Oryzanol

Background and Objectives: For a long time, Asian women have known to use rice water, rice bran for skin care, lightening dark spots and slowing down the aging process. Gamma Oryzanol, an ester mixture of trans-ferulic acid with phytosterols and triterpene alcohols extracted from rice bran oil, has been shown to have beneficial effects on the skin, especially its antioxidant and anti-aging effect. The aims of this research were to formulate Gamma Oryzanol-loaded anti-aging cream and to evaluate the product quality. Materials and Methods: Gamma Oryzanol was imported from Japan. Some formulation parameters such as emulsifi-ers, performance modifiers were investigated and the product quality was evaluated according to the criteria of drugs and cosmetics. Results: The excipients were chosen including 1% (w/w) of Lunamer with 3% (w/w) of Prolipid as emulsifiers and 8% (w/w) of mango seed butter as a state modifier in the formulation of Gamma Oryzanol anti-aging cream. The cream is ivory-white, thick, smooth, fragrant-smelling and satisfied all criteria of developed specification. Conclusion: The study was successful in the preparation of Gamma Oryzanol anti-aging cream. Key words: Gamma Oryzanol, anti-aging cream, Franz cells.

scholarly journals The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver

2021 ◽  
Vol 22 (4) ◽  
pp. 1665
Author(s):  
Guglielmina Chimienti ◽  
Anna Picca ◽  
Flavio Fracasso ◽  
Francesco Russo ◽  
Antonella Orlando ◽  
...  
Keyword(s):  
Calorie Restriction ◽  
Citrate Synthase ◽  
Aging Effect ◽  
Mtdna Damage ◽  
Mitochondrial Markers ◽  
Age Related ◽  
Efficacious Treatment ◽  
Mtdna Deletion ◽  
Cyt C ◽  
Ad Libitum

Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement.

scholarly journals Greener Solution to Waste Corn Stalks and Shortage of Asphalt Resource: Hydrochar Produced by Hydrothermal Carbonization as a Novel Performance Enhancer for Asphalt Binder

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1427
Author(s):  
Xiaoming Wu ◽  
Chichun Hu
Keyword(s):  
High Temperature ◽  
Reaction Temperature ◽  
Storage Stability ◽  
Asphalt Binder ◽  
Aging Effect ◽  
Experimental Tests ◽  
Hydrothermal Carbonization ◽  
Modified Asphalt ◽  
Direct Combustion ◽  
Aging Property

Utilization of waste corn stalks (CS) has seized extensive attention due to high annual output and hazardous impact of piling aside or direct combustion on environment. However, previously there has been a lot of emphasis on improvement of its energy efficiency as solid fuel while limited investigations are available which explore the possibility of applying corn stalks as performance enhancer in asphalt binder. The purpose of this study is to examine the potential of employing hydrochar as modifiers in asphalt binder by a series of experimental tests. In this study, two hydrochar were produced from corn stalks by a novel process called hydrothermal carbonization at a different reaction temperature. The two hydrochar and their responding hydrochar-modified asphalt (HCMA) were tested by chemical and rheological tests. Chemical analysis detected the interaction between hydrochar and binder factions, resulting in poor compatibility but satisfying anti-aging property. Even though hydrochar increased the viscosity of bitumen, implying worse workability, and caused poor storage stability, ameliorated performance of asphalt binder at high temperature by incorporating hydrochar was verified by various criteria such as higher performance grade (PG) failure temperature and lower non-recoverable creep compliance (Jnr). Moreover, higher reaction temperature makes hydrochar’s particles smaller and more homogeneous, which results in slightly lower enhanced high temperature performance, more satisfying workability, better storage stability, and greater anti-aging effect of hydrochar-modified asphalt. Eventually, this study provided a promising win-win solution to environment problems concerning corn stalk treatment and shortage of asphalt binder. Further exploration of methods to improve HCMA’s storage stability, real-scale corroboration on trial section and life cycle assessment of asphalt pavement containing hydrochar modifiers will be followed in the future.

Aging effect on head motion: A Machine Learning study on resting state fMRI data

2021 ◽  
Vol 352 ◽  
pp. 109084
Author(s):  
Valeria Saccà ◽  
Alessia Sarica ◽  
Andrea Quattrone ◽  
Federico Rocca ◽  
Aldo Quattrone ◽  
...  
Keyword(s):  
Machine Learning ◽  
Resting State ◽  
Aging Effect ◽  
Resting State Fmri ◽  
Fmri Data ◽  
Head Motion ◽  
Learning Study

Age dependency of the diabetes effects on the iris recognition systems performance evaluation results

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Mohammadreza Azimi ◽  
Seyed Ahmad Rasoulinejad ◽  
Andrzej Pacut
Keyword(s):  
Iris Recognition ◽  
Recognition Task ◽  
Aging Effect ◽  
Recognition System ◽  
Health Condition ◽  
Age Dependency ◽  
Biometric Systems ◽  
Kolmogorov Smirnov ◽  
Recognition Systems ◽  
Smirnov Test

AbstractIn this paper, we attempt to answer the questions whether iris recognition task under the influence of diabetes would be more difficult and whether the effects of diabetes and individuals’ age are uncorrelated. We hypothesized that the health condition of volunteers plays an important role in the performance of the iris recognition system. To confirm the obtained results, we reported the distribution of usable area in each subgroup to have a more comprehensive analysis of diabetes effects. There is no conducted study to investigate for which age group (young or old) the diabetes effect is more acute on the biometric results. For this purpose, we created a new database containing 1,906 samples from 509 eyes. We applied the weighted adaptive Hough ellipsopolar transform technique and contrast-adjusted Hough transform for segmentation of iris texture, along with three different encoding algorithms. To test the hypothesis related to physiological aging effect, Welches’s t-test and Kolmogorov–Smirnov test have been used to study the age-dependency of diabetes mellitus influence on the reliability of our chosen iris recognition system. Our results give some general hints related to age effect on performance of biometric systems for people with diabetes.

scholarly journals Universal Plasma Jet for Droplet Manipulation on a PDMS Surface towards Wall-Less Scaffolds

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1321
Author(s):  
Cheng-Yun Peng ◽  
Chia-Hung Dylan Tsai
Keyword(s):  
Plasma Treatment ◽  
Treatment Time ◽  
Plasma Jet ◽  
Aging Effect ◽  
Droplet Generation ◽  
Magnetic Actuation ◽  
Pdms Surface ◽  
Polymeric Surface ◽  
Air Jet ◽  
Droplet Manipulation

Droplet manipulation is important in the fields of engineering, biology, chemistry, and medicine. Many techniques, such as electrowetting and magnetic actuation, have been developed for droplet manipulation. However, the fabrication of the manipulation platform often takes a long time and requires well-trained skills. Here we proposed a novel method that can directly generate and manipulate droplets on a polymeric surface using a universal plasma jet. One of its greatest advantages is that the jet can tremendously reduce the time for the platform fabrication while it can still perform stable droplet manipulation with controllable droplet size and motion. There are two steps for the proposed method. First, the universal plasma jet is set in plasma mode for modifying the manipulation path for droplets. Second, the jet is switched to air-jet mode for droplet generation and manipulation. The jetted air separates and pushes droplets along the plasma-treated path for droplet generation and manipulation. According to the experimental results, the size of the droplet can be controlled by the treatment time in the first step, i.e., a shorter treatment time of plasma results in a smaller size of the droplet, and vice versa. The largest and the smallest sizes of the generated droplets in the results are about 6 µL and 0.1 µL, respectively. Infrared spectra of absorption on the PDMS surfaces with and without the plasma treatment are investigated by Fourier-transform infrared spectroscopy. Tests of generating and mixing two droplets on a PDMS surface are successfully achieved. The aging effect of plasma treatment for the proposed method is also discussed. The proposed method provides a simple, fast, and low-cost way to generate and manipulate droplets on a polymeric surface. The method is expected to be applied to droplet-based cell culture by manipulating droplets encapsulating living cells and towards wall-less scaffolds on a polymeric surface.

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