The stratum corneum water content and natural moisturization factor composition evolve with age and depend on body site

2021 ◽  
Author(s):  
Elise Boireau‐Adamezyk ◽  
Arlette Baillet‐Guffroy ◽  
Georgios N. Stamatas
Keyword(s):  
Stratum Corneum ◽  
Water Content ◽  
Body Site ◽  
Stratum Corneum Water Content

scholarly journals Acetyl hexapeptide-3 in a cosmetic formulation acts on skin mechanical properties - clinical study

2015 ◽  
Vol 51 (4) ◽  
pp. 901-909 ◽  
Author(s):  
Kassandra Azevedo Tadini ◽  
Daiane Garcia Mercurio ◽  
Patrícia Maria Berardo Gonçalves Maia Campos
Keyword(s):  
Mechanical Properties ◽  
Stratum Corneum ◽  
Water Content ◽  
Topical Formulations ◽  
Face Area ◽  
Cutaneous Tissue ◽  
The Face ◽  
Skin Conditions ◽  
Basic Studies ◽  
Stratum Corneum Water Content

abstract Acetyl hexapeptide-3 has been used in anti-aging topical formulations aimed at improving skin appearance. However, few basic studies address its effects on epidermis and dermis, when vehiculated in topical formulations. Thus, the objective of this study was to determine the clinical efficacy of acetyl hexapeptide-3 using biophysical techniques. For this purpose, formulations with and without acetyl hexapeptide-3 were applied to the ventral forearm and the face area of forty female volunteers. Skin conditions were evaluated after 2 and 4-week long daily applications, by analyzing the stratum corneum water content and the skin mechanical properties, using three instruments, the Corneometer(r) CM 825, CutometerSEM 575 and ReviscometerRV600. All formulations tested increased the stratum corneum water content in the face region, which remained constant until the end of the study. In contrast, only formulations containing acetyl hexapeptide-3 exhibit a significant effect on mechanical properties, by decreasing the anisotropy of the face skin. No significant effects were observed in viscoelasticity parameters. In conclusion, the effects of acetyl hexapeptide-3 on the anisotropy of face skin characterize the compound as an effective ingredient for improving conditions of the cutaneous tissue, when used in anti-aging cosmetic formulations.

Epidermal thermal conductivity and stratum corneum hydration in cat footpad

1975 ◽  
Vol 228 (6) ◽  
pp. 1903-1908 ◽  
Author(s):  
KR Holmes ◽  
T Adams
Keyword(s):  
Thermal Conductivity ◽  
Stratum Corneum ◽  
Water Content ◽  
Skin Surface ◽  
Blocking Agent ◽  
Eccrine Sweat Gland ◽  
Dermoepidermal Junction ◽  
Stratum Corneum Hydration ◽  
Cutaneous Vasoconstriction ◽  
Stratum Corneum Water Content

Epidermal thermal conductivity (k) was calculated for the cat footpad by measuringtransepidermal heat flux and temperature gradient ( inverted question markT) while changes in stratum corneum water content were produced by "internal hydration" (IH; eccrine sweat gland activity by nerve stimulation) or by "external hydration" (HH; exposure to air saturated with water vapor). In some experiments, cutaneous vasoconstriction accompanying IH was prevented by an alpha-adrenergic receptor blocking agent, phenoxybenzamine (POB), 3.52 mg/kg iv. For dry skin k=0.167 plus or minus 0.023 (SE) W.m (-1) degree C (-1). With and without POB, IH produced 49.5% and 17.2% increases in k, respectively; HH after IH did not increase k more. With POB, IH increased k more than did HH alone (49.5% and 15.5%, respectively) and at a higher rate (4.22 times 10 minus 3 and 0.63 times 10 minus 3 W.m minus 1.degree C minus 1. min minus 1, respectively.) As k increased, usually deltaT decreased. Increasing k and decreasing deltaT with skin hydration explain the phenominon that air temperature is felt to be lower the more humid a cold exposure, since the temperature of thermoreceptors at the dermoepidermal junction is closer to that of the skin surface when the corneum is hydrated than when it has a low water content.

Effect of wearing cotton or polyester pajamas on stratum corneum water content under mildly cold conditions

2006 ◽  
Vol 55 (5) ◽  
pp. 910-912 ◽  
Author(s):  
Lei Yao ◽  
Hiromi Tokura ◽  
Yi Li ◽  
Edwards Newton ◽  
Mayur Danny I. Gohel
Keyword(s):  
Stratum Corneum ◽  
Water Content ◽  
Stratum Corneum Water Content

scholarly journals Moisturizing effect of a cosmetic formulation containing pequi oil (Caryocar brasiliense) from the Brazilian cerrado biome

2014 ◽  
Vol 50 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Wanessa Costa Silva Faria ◽  
Gabriel Azevedo de Brito Damasceno ◽  
Márcio Ferrari
Keyword(s):  
Stratum Corneum ◽  
Water Content ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Brazilian Cerrado ◽  
Single Application ◽  
Caryocar Brasiliense ◽  
Stratum Corneum Water Content

Caryocar brasiliense, popularly known in Brazil as “pequi”, is a species widely distributed in the Brazilian Cerrado. The seeds are surrounded by a woody endocarp coated with a yellow fleshy mesocarp rich in oil and vitamin A, whose oil has a useful role in the treatment of skin aging and protection of human skin against UV-induced damage and skin hydration. The aim of this study was to evaluate the effect of cosmetic formulations containing pequi oil (Caryocar brasiliense) on skin hydration, after a single application. Hydration effect assessment was performed by applying the formulations under study (Control – no formulation, vehicle, and vehicle + pequi oil) onto forearm skin of 30 human volunteers. Skin capacitance and Transepidermal Water Loss (TEWL) measurements were analyzed before, and at 1, 2 and 3 hours after, a single application. Evaluation results of a single application of the vehicle containing pequi oil showed an increase in stratum corneum water content, indicating a skin moisturizing effect. Results of the evaluation of immediate effects of TEWL demonstrated that the vehicle containing pequi oil significantly increased skin moisture during the 3 h evaluation period. The formulations containing pequi oil showed clinical efficacy, increasing stratum corneum water content and enhancing skin barrier function.

scholarly journals Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2220
Author(s):  
Tzu-Fang Hsu ◽  
Zi-Rong Su ◽  
Yao-Hao Hsieh ◽  
Ming-Fu Wang ◽  
Mariko Oe ◽  
...  
Keyword(s):  
Placebo Group ◽  
Stratum Corneum ◽  
Water Content ◽  
Water Loss ◽  
Group Versus ◽  
Transepidermal Water Loss ◽  
Skin Condition ◽  
Joint Fluid ◽  
Controlled Study ◽  
Stratum Corneum Water Content

Hyaluronan (HA) is present in all connective tissues and organs, including the skin and joint fluid. However, few clinical trials have comprehensively evaluated the impacts of oral HA on skin conditions, including wrinkles and moisturization. In this study, we conducted a placebo-controlled, randomized, double-blind trial of daily HA (120 mg) intake for 12 weeks in 40 healthy Asian men and women (aged 35–64 years). Skin condition was determined by the evaluation of wrinkles, stratum corneum water content, the amount of transepidermal water loss, elasticity, and through image analysis. After 12 weeks, skin condition was significantly improved in terms of wrinkle assessment, stratum corneum water content, transepidermal water loss, and elasticity in the HA group compared to the placebo group. Regarding the percentage change from baseline, wrinkle assessment, stratum corneum water content, and skin elasticity were significantly improved in the HA group versus the placebo group after 8 and 12 weeks of ingestion. The present findings indicate that oral ingestion of HA may suppress wrinkles and improve skin condition.

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