Pirfenidone‐induced phototoxic reaction

2020 ◽  
Author(s):  
Daniel Morgado‐Carrasco ◽  
Jaume Massana ◽  
Jaime Piquero‐Casals
Keyword(s):  
Phototoxic Reaction

scholarly journals A Case of Unilateral Hyperpigmentation

Dermato ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 26-30
Author(s):  
Yujin Han ◽  
Se-Hoon Lee ◽  
Minah Cho ◽  
Sang-Hyun Cho ◽  
Jeong-Deuk Lee ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Contact Area ◽  
Nd:Yag Laser ◽  
Intense Pulsed Light ◽  
Citrus Fruits ◽  
Pulsed Light ◽  
Detailed History ◽  
Clinical Presentations ◽  
Phototoxic Reaction ◽  
Plant Compounds

Phytophotodermatitis is a cutaneous phototoxic reaction resulting from contact with plant compounds such as furocoumarin in citrus fruits, followed by exposure to ultraviolet light. Erythema and vesicles appear on the contact area, followed by hyperpigmented lesions. Hyperpigmentation may exist for weeks to months before fading but can remain up to several years. Diagnosis is often challenging due to the variety of clinical presentations, and it is not always easy to identify trigger exposures. A detailed history is key to diagnosis. We herein report a case of lime-induced phytophotodermatitis which was initially mistaken for unilateral lentiginosis. The patient underwent Q-switched Nd:YAG laser and intense pulsed light (IPL) treatment with immediate improvement.

Inflammatory involvement into phototoxic reaction in erythropoietic protoporphyria (EPP) patients

2019 ◽  
Vol 67 (4-5) ◽  
pp. 382-389 ◽  
Author(s):  
Francesca Granata ◽  
Lorena Duca ◽  
Giovanna Graziadei ◽  
Valentina Brancaleoni ◽  
Pasquale Missineo ◽  
...  
Keyword(s):  
Erythropoietic Protoporphyria ◽  
Phototoxic Reaction

Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol

2021 ◽  
Vol 13 (575) ◽  
pp. eaba3571
Author(s):  
Min Lu ◽  
Shen Wang ◽  
Tao Wang ◽  
Sisi Hu ◽  
Brijesh Bhayana ◽  
...  
Keyword(s):  
Blue Light ◽  
Mammalian Cells ◽  
Bacterial Infections ◽  
Bacterial Resistance ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Multidrug Resistant ◽  
Skin Wound ◽  
Bacterial Colony ◽  
Phototoxic Reaction

Development of alternatives to antibiotics is one of the top priorities in the battle against multidrug-resistant (MDR) bacterial infections. Here, we report that two naturally occurring nonantibiotic modalities, blue light and phytochemical carvacrol, synergistically kill an array of bacteria including their planktonic forms, mature biofilms, and persisters, irrespective of their antibiotic susceptibility. Combination but not single treatment completely or substantially cured acute and established biofilm-associated Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus infections of full thickness murine third-degree burn wounds and rescued mice from lethal Pseudomonas aeruginosa skin wound infections. The combined therapy diminished bacterial colony-forming units as high as 7.5 log10 within 30 min and introduced few adverse events in the survival of cocultured mammalian cells, wound healing, or host DNA. Mechanistic studies revealed that carvacrol was photocatalytically oxidized into a series of photoreactive substrates that underwent photolysis or additional photosensitization reactions in response to the same blue light, forming two autoxidation cycles that interacted with each other resulting in robust generation of cytotoxic reactive oxygen species. This phototoxic reaction took place exclusively in bacteria, initiated by blue light excitation of endogenous porphyrin-like molecules abundantly produced in bacteria compared with mammalian cells. Moreover, no bacterial resistance developed to the combined treatment after 20 successive passages. This highly selective phototoxic reaction confers a unique strategy to combat the growing threat of MDR bacteria.

PHOTOTOXIC REACTION TO XANTHENE DYES INDUCED BY VISIBLE LIGHT

1976 ◽  
Vol 3 (2) ◽  
pp. 59-67 ◽  
Author(s):  
Fujio Morikawa ◽  
Minoru Fukuda ◽  
Masako Naganuma ◽  
Yasuhisa Nakayama
Keyword(s):  
Visible Light ◽  
Xanthene Dyes ◽  
Phototoxic Reaction

Phototoxic reaction from vegetables

1987 ◽  
Vol 19 (3) ◽  
pp. 339
Author(s):  
P Ratka ◽  
T Sloboda
Keyword(s):  
Phototoxic Reaction

Phototoxic reaction to fenofibrate

1990 ◽  
Vol 23 (4) ◽  
pp. 284-284 ◽  
Author(s):  
Victoria Merino ◽  
Rapael Llamas ◽  
Luis Iglesias
Keyword(s):  
Phototoxic Reaction

scholarly journals Multifocal Aggressive Squamous Cell Carcinomas Induced by Prolonged Voriconazole Therapy: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
C. Morice ◽  
A. Acher ◽  
N. Soufir ◽  
M. Michel ◽  
F. Comoz ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Fungal Infections ◽  
Gene Mutations ◽  
Skin Lesions ◽  
Squamous Cell Carcinomas ◽  
Skin Carcinogenesis ◽  
Skin Reactions ◽  
Exposed Skin ◽  
Plausible Hypothesis ◽  
Phototoxic Reaction

Voriconazole is a treatment for severe fungal infections. Prolonged voriconazole therapy may induce skin reactions, with 1% of severe photosensitivity accidents. Recently the imputability of voriconazole in skin carcinogenesis has been suggested. This report concerns a 55-year-old man suffering from pulmonary aspergillosis who presented a phototoxic reaction a few months after introduction of voriconazole, followed by multiple squamous cell carcinomas of sun-exposed skin areas. After voriconazole discontinuation, no new carcinoma was observed. The detection of EBV and HPV in skin lesions was negative. Exploration of gene mutations involved in skin carcinogenesis showed two variants of theMICRgene. The occurrence of multiple, recurrent, aggressive squamous cell carcinomas is rare with voriconazole, but its imputability is strongly suggested. A plausible hypothesis is that several factors including voriconazole uptake, immunosuppression, and genetic background could explain the phenotype of fast-developing skin carcinomas. Voriconazole therapy should be accompanied by stringent photoprotection and skin monitoring.

Pirfenidone-induced severe phototoxic reaction in a patient with idiopathic lung fibrosis

2016 ◽  
Vol 30 (8) ◽  
pp. 1354-1356 ◽  
Author(s):  
E. Papakonstantinou ◽  
A. Prasse ◽  
V. Schacht ◽  
A. Kapp ◽  
U. Raap
Keyword(s):  
Lung Fibrosis ◽  
Phototoxic Reaction
Sign in / Sign up

Export Citation Format

Share Document