Basal cell carcinoma of the groin and buttocks: a clinical and histological analysis of a rare presentation of a common tumor

2019 ◽  
Vol 58 (8) ◽  
pp. 972-975
Author(s):  
W. James Tidwell ◽  
Adam Sutton ◽  
Ryan Gilbertson ◽  
Cora Humberson ◽  
Hubert Greenway
2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Lynne Robertson ◽  
Maxwell B. Sauder

Background. Darier's disease (DD), also known as Keratosis Follicularis or Darier-White disease, is a rare disorder of keratinization. DD can present as a generalized autosomal dominant condition as well as a localized or segmental postzygotic condition (Vázquez et al., 2002). Clinical features of DD include greasy, warty papules and plaques on seborrheic areas, dystrophic nails, palmo-plantar pits, and papules on the dorsum of the hands and feet.Objective. We report a case of basal cell carcinoma developing in a patient with type 2 segmental DD.Conclusion. According to the current literature, Type 2 segmental disease is a rare presentation of Darier's disease with only 8 previous cases reported to date. In addition, nonmelanoma skin cancer (NMSC) arising from DD is rarely reported; however, there may be an association between DD and risk of carcinogenesis.


2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Audrey V. Carr ◽  
Edward Feller ◽  
Fouad R. Zakka ◽  
Rogers C. Griffith ◽  
Steven Schechter

Basal cell carcinoma (BCC), a common malignancy, arises most often in sun-exposed areas but does rarely occur in non-sun-exposed sites. Prior tissue injury, especially sharp trauma and chronic inflammation, increases the risk of BCC. We describe a 66-year-old male patient with recurrent perianal abscesses who was found to have a large pigmented basal cell carcinoma. The mass was excised without recurrence at two-year follow-up. Perianal BCC is commonly larger at the time of diagnosis than tumors in sun-exposed sites, likely related to delay in diagnosis. Increased size can lead to increased surgical complexity and more pronounced effects on nearby structures. Early detection is important for optimal patient outcomes. In selected patients presenting with a perianal mass, basal cell carcinoma should be included on the differential diagnosis.


2005 ◽  
Vol 30 (5) ◽  
pp. 459-460
Author(s):  
R. NASSAB ◽  
S. RAYATT ◽  
F. PEART

This paper presents a rare hand presentation of Gorlin’s Syndrome, also known as Naevoid Basal Cell Carcinoma Syndrome, which has not been reported previously. This condition is an autosomal dominant, multisystem condition whose diagnosis is important to ensure further surveillance and treatment of features of the condition not routinely dealt with by hand surgeons. However, hand surgeons should be aware of this condition and those parts of the syndrome which may present to them.


2016 ◽  
Vol 7 (4) ◽  
pp. 285 ◽  
Author(s):  
AtulM Dongre ◽  
UdayS Khopkar ◽  
YogeshN Kalyanpad ◽  
PrachiV Gole

2021 ◽  
Vol 5 (1) ◽  
pp. 37-40
Author(s):  
Brian Wanner ◽  
Austin Cusick ◽  
Jyoti Kapil ◽  
Stephen D'Addario

Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer (NMSC) with the potential of local invasion and distant metastasis. Our patient presented with an enlarging four-centimeter subcutaneous nodule over the right clavicle. An incisional biopsy demonstrated the unexpected findings of a nodular and infiltrative BCC. Definitive treatment was a radical neck dissection with adjuvant radiation therapy. Negative margins were confirmed on the excision and lymph node evaluation demonstrated no lymphatic spread. Surveillance chest computed tomography revealed new bilateral pulmonary nodules and a subsequent biopsy showed metastatic BCC. A genetic panel demonstrated TP53 mutations and no mutations in SMO. The patient was started on sonidegib and after ten months of therapy his disease was stabilized on repeat imaging. This case report demonstrates a rare presentation of a TP53 mutated, metastatic BCC responsive to sonidegib.


Author(s):  
Victoria L. Wade ◽  
Winslow G. Sheldon ◽  
James W. Townsend ◽  
William Allaben

Sebaceous gland tumors and other tumors exhibiting sebaceous differentiation have been described in humans (1,2,3). Tumors of the sebaceous gland can be induced in rats and mice following topical application of carcinogens (4), but spontaneous mixed tumors of basal cell origin rarely occur in mice.


2000 ◽  
Vol 39 (5) ◽  
pp. 397-398 ◽  
Author(s):  
Hyoung-Joo Kim ◽  
Youn-Soo Kim ◽  
Ki-Beom Suhr ◽  
Tae-Young Yoon ◽  
Jeung-Hoon Lee ◽  
...  

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