An unusual case of methicillin-resistant Staphylococcus aureus necrotic soft tissue infection of the lip

2017 ◽  
Vol 56 (12) ◽  
pp. 1475-1477 ◽  
Author(s):  
Amrit K. Kamboj ◽  
Thomas G. Cotter ◽  
Marian T. McEvoy ◽  
Mark D. Davis ◽  
Donna M. Miller
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Unusual Case ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Tissue Infection ◽  
Methicillin Resistant

scholarly journals Risk Factors Associated With Methicillin-Resistant Staphylococcus aureus (MRSA) Complicated Skin and Soft Tissue Infection in Colombia

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Sandra Liliana Valderrama Beltran ◽  
Sandra Gualtero ◽  
Jose Rodriguez ◽  
Johanna Osorio ◽  
Carlos Arturo Alvarez Moreno ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Tissue Infection ◽  
Methicillin Resistant ◽  
Factors Associated ◽  
Complicated Skin

scholarly journals HOME2 Study: Household Versus Personalized Decolonization in Households of Children With Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection—A Randomized Clinical Trial

2020 ◽  
Author(s):  
Patrick G Hogan ◽  
Katelyn L Parrish ◽  
Ryan L Mork ◽  
Mary G Boyle ◽  
Carol E Muenks ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Tissue Infection ◽  
Methicillin Resistant ◽  
Home Study ◽  
Intranasal Mupirocin ◽  
Household Members ◽  
Personalized Approach

Abstract Background A household approach to decolonization decreases skin and soft tissue infection (SSTI) incidence, though this is burdensome and costly. As prior SSTI increases risk for SSTI, we hypothesized that the effectiveness of decolonization measures to prevent SSTI when targeted to household members with prior year SSTI would be noninferior to decolonizing all household members. Methods Upon completion of our 12-month observational Household Observation of Methicillin-resistant Staphylococcus aureus in the Environment (HOME) study, 102 households were enrolled in HOME2, a 12-month, randomized noninferiority trial. Pediatric index patients with community-associated methicillin-resistant Staphylococcus aureus (MRSA) SSTI, their household contacts, and pets were enrolled. Households were randomized 1:1 to the personalized (decolonization performed only by household members who experienced SSTI during the HOME study) or household (decolonization performed by all household members) approaches. The 5-day regimen included hygiene education, twice-daily intranasal mupirocin, and daily bleach-water baths. At 5 follow-up visits in participants’ homes, swabs to detect S. aureus were collected from participants, environmental surfaces, and pets; incident SSTIs were ascertained. Results Noninferiority of the personalized approach was established for the primary outcome 3-month cumulative SSTI: 23 of 212 (10.8%) participants reported SSTI in household approach households, while 23 of 236 (9.7%) participants reported SSTI in personalized approach households (difference in proportions, −1.1% [95% confidence interval, −6.7% to 4.5%]). In multivariable analyses, prior year SSTI and baseline MRSA colonization were associated with cumulative SSTI. Conclusions The personalized approach was noninferior to the household approach in preventing SSTI. Future studies should interrogate longer durations of decolonization and/or decontamination of the household environment to reduce household MRSA burden. Clinical Trials Registration NCT01814371.

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