Symmetrical drug-related intertriginous and flexural erythema (Baboon syndrome) induced by simultaneous exposure to oral and topical terbinafine

2017 ◽  
Vol 56 (8) ◽  
pp. e168-e170 ◽  
Author(s):  
Neetu Bhari ◽  
Kanika Sahni ◽  
Tanvi Dev ◽  
Vinod K. Sharma
Keyword(s):  
Simultaneous Exposure

Exclusionary Reactions to Foreign Cultures: Effects of Simultaneous Exposure to Cultures in Globalized Space

2011 ◽  
Vol 67 (4) ◽  
pp. 716-742 ◽  
Author(s):  
Carlos J. Torelli ◽  
Chi-Yue Chiu ◽  
Kim-pong Tam ◽  
Al K. C. Au ◽  
Hean Tat Keh
Keyword(s):  
Simultaneous Exposure

scholarly journals A comparative assessment of dry eye disease among outdoor street sweepers and indoor office cleaners

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chigozie I. Echieh ◽  
Bassey A. Etim ◽  
Chidiebere Peter Echieh ◽  
Taiwo Oyeniyi ◽  
Jeff Ajewole
Keyword(s):  
Dry Eye ◽  
Cross Sectional Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Simultaneous Exposure ◽  
Cross Sectional ◽  
Systematic Random Sampling ◽  
Schirmer’S Test ◽  
Multi Stage

Abstract Background Occupational predisposition to dry eye disease is known. Simultaneous exposure to multiple factors may pose more risk. Street sweepers are exposed to sunlight in addition to dust which all sweepers are exposed to. Tropical climate predisposes to significant exposure to sunlight. Combined exposure to dust and sunlight may lead to a synergy of factors. This study aims to assess the prevalence of dry eye disease (DED) amongst Street sweepers and Office cleaners in Calabar metropolis. Methods A cross-sectional study was conducted among street sweepers and office cleaners. A systematic random sampling and multi-stage sampling method were used to select street sweepers (n = 115) and office cleaners (n = 115) respectively for the study. A pretested semi-structured interviewer-administered questionnaire was used to obtain information after which the respondents had an ophthalmic examination. An assessment of DED was done with Ocular Surface Disease Index (OSDI) questionnaire, Schirmer’s test, and tear break up time (TBUT). OSDI scores of 33 and above; Schirmer’s test readings of < 10 mm wetting in 5 min and a TBUT of less than 10s in either eye were considered as positive dry eye disease. Results The majority of respondents were females 215(93.5%) compared to males 15 (6.5%). The overall mean age of respondents was 40.96 ± 9.8 years. The average OSDI score, Schirmer’s test as well as TBUT among participants was 26.4 ± 16.0, 16.44 ± 9.52 mm, and 12.38 ± 4.53 s respectively. The prevalence of DED among Street sweepers was 35.7% compared to 20% among office cleaners using the OSDI questionnaire (p = 0.352). The prevalence of DED among street sweepers was 32.2% compared to 30.4% among Office cleaners using the Schirmer’s test. (p = 0.73) The TBUT reported a prevalence of 38.3% of DED among Street sweepers compared to 32.2% in office cleaners. (p = 0.48) Overall; the prevalence of dry eye disease among Street sweepers and office cleaners using OSDI score, Schirmers test, as well as TBUT were not statistically significant (> 0.05) Street Sweepers had higher odds of developing dry eye disease compared to office cleaners (OR = 2.085; C.I. =1.106–3.929; p = 0.02). Negative correlation coefficient was observed between TBUT and OSDI (rs = − 0.102; p = 0.125). This was not statistically significant. Conclusion Street sweepers had a higher prevalence of dry eye disease compared to office cleaners due to a higher risk of increased exposure to environmental factors such as dust, smoke, and sunlight. This effect is possibly due to a synergy of factors. Studies on dose-response are warranted.

Effect of water stress and NaCl triggered changes on yield, physiology, biochemistry of broad bean (Vicia faba) plants and on quality of harvested pods

Biologia ◽  
2014 ◽  
Vol 69 (8) ◽  
Author(s):  
Georgia Ouzounidou ◽  
Ilias Ilias ◽  
Anastasia Giannakoula ◽  
Ioanna Theoharidou
Keyword(s):  
Water Stress ◽  
Field Experiments ◽  
Broad Bean ◽  
Foliar Application ◽  
Water Control ◽  
Simultaneous Exposure ◽  
Ameliorative Effect ◽  
Normal Water ◽  
The Impact

AbstractSalinity and drought are the most important abiotic stresses affecting crop yield. Broad bean was chosen as model plant for assessing the impact of salt stress and its interaction with drought in the field experiments. The factors examined in the experiments were the two irrigation rates (normal watering — NW with 3 L plant−1 and drought — D) and three salinity rates imposed by foliar application (0, 50, 100 mg L−1 NaCl). Highest NaCl level with normal water irrigation caused maximum reduction in plant height and production, which it was due to photosynthetic disturbances. Salt injuries were alleviated by increasing water stress. The control plants exposed to NaCl lost their ability over water control. The increased malondialdehyde (MDA) and H2O2 indicate the prevalence of oxidative stress due to salinity. The levels of proline and carbohydrates were higher under salinity alone than under simultaneous exposure to drought and NaCl. The protein concentration of immature and mature broad bean pods was more inhibited more by NaCl supply than by drought alone. The combination of drought and NaCl resulted in a significant increase in proteins, glucose, fructose and sucrose content. Overall, the ameliorative effect of drought under NaCl supply was quantified.

Simultaneous exposure to intracellular and extracellular photosensitizers for the treatment of Staphylococcus aureus infections

2021 ◽  
Author(s):  
Sydney L. Drury ◽  
Anderson R. Miller ◽  
Clare L. Laut ◽  
Alec B. Walter ◽  
Monique R. Bennett ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Near Infrared ◽  
Antimicrobial Photodynamic Therapy ◽  
Biological Processes ◽  
Drug Resistant ◽  
Soft Tissue Infections ◽  
Positive Bacterium ◽  
Human Monoclonal Antibodies ◽  
Simultaneous Exposure

Staphylococcus aureus is a serious threat to public health due to the rise of antibiotic resistance in this organism, which can prolong or exacerbate skin and soft tissue infections (SSTIs). Methicillin-resistant S. aureus is a Gram-positive bacterium and a leading cause of SSTIs. As such, many efforts are underway to develop therapies that target essential biological processes in S. aureus . Antimicrobial photodynamic therapy is effective alternative to antibiotics, therefore we developed an approach to simultaneously expose S. aureus to intracellular and extracellular photoactivators. A near infrared photosensitizer was conjugated to human monoclonal antibodies (mAbs) that target the S. aureus Isd heme acquisition proteins. Additionally, the compound VU0038882 was developed to increase photoactivatable porphyrins within the cell. Combinatorial PDT treatment of drug-resistant S. aureus exposed to VU0038882 and conjugated anti-Isd mAbs proved to be an effective antibacterial strategy in vitro and in a murine model of SSTIs.

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