Second primary melanoma on a patient undergoing vemurafenib therapy. A case report

2017 ◽  
Vol 56 (7) ◽  
pp. 792-794 ◽  
Author(s):  
Giuliana Onnis ◽  
Giuseppe Palmieri ◽  
Maria Antonietta Montesu ◽  
Rosanna Satta
Keyword(s):  
Case Report ◽  
Primary Melanoma ◽  
Second Primary

Second primary cancer in reconstructed neopharynx: a case report

2017 ◽  
Vol 33 (2) ◽  
pp. 89-93
Author(s):  
Karam Kang ◽  
◽  
Hye Min Han ◽  
Hyunjung Kim ◽  
Seung-Kuk Baek ◽  
...  
Keyword(s):  
Case Report ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

EML4-ALK translocation in both metachronous second primary lung sarcomatoid carcinoma and lung adenocarcinoma: A case report

Lung Cancer ◽  
2013 ◽  
Vol 81 (2) ◽  
pp. 297-301 ◽  
Author(s):  
Greta Alì ◽  
Agnese Proietti ◽  
Cristina Niccoli ◽  
Serena Pelliccioni ◽  
Nicla Borrelli ◽  
...  
Keyword(s):  
Case Report ◽  
Lung Adenocarcinoma ◽  
Sarcomatoid Carcinoma ◽  
Second Primary

Simultaneous double laryngeal tumours: a diagnostic and therapeutic challenge

2021 ◽  
Vol 14 (2) ◽  
pp. e239797
Author(s):  
Fergus Cooper ◽  
Rafael Moleron ◽  
Andrea Chapman ◽  
Muhammad Shakeel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Soft Tissue ◽  
Histological Analysis ◽  
Primary Tumour ◽  
Second Primary ◽  
Soft Tissue Tumours ◽  
Rare Presentation ◽  
Laryngeal Tumours ◽  
Second Primary Tumour

Leiomyosarcomas are soft tissue tumours that rarely occur in the larynx. This case report describes the presentation and management of a 77-year-old man referred to the otolaryngology clinic with hoarseness who was found to have a large supraglottic leiomyosarcoma after panendoscopy and biopsies. He subsequently underwent laryngectomy for treatment of this tumour but, unexpectedly, the histological analysis of the laryngectomy specimen revealed a second primary tumour in the larynx—a squamous cell carcinoma (SCC). The patient had further treatment with neck radiotherapy. Three years after treatment, there are no signs of recurrence of either tumour. This case report discusses the very few similar cases of leiomyosarcoma coexisting with SCC in the larynx, collating the evidence surrounding the treatment of this rare presentation.

Second Primary Melanomas: Incidence and Outcome

2010 ◽  
Vol 76 (7) ◽  
pp. 675-681 ◽  
Author(s):  
Matthew R. Bower ◽  
Charles R. Scoggins ◽  
Robert C. G. Martin ◽  
Michael P. Mays ◽  
Michael J. Edwards ◽  
...  
Keyword(s):  
Early Stage ◽  
Primary Melanoma ◽  
Disease Free Survival ◽  
Second Primary ◽  
Free Survival ◽  
Kaplan Meier ◽  
Ongoing Surveillance ◽  
Post Hoc ◽  
Disease Free

The objective of this study was to determine the incidence of multiple primary melanomas (MPM) and other cancers types among patients with melanoma. Factors associated with development of MPM were assessed in a post hoc analysis of the database from a multi-institutional prospective randomized trial of patients with melanoma aged 18 to 70 years with Breslow thickness 1 mm or greater. Disease-free survival (DFS) and overall survival (OS) were evaluated by Kaplan-Meier analysis. Forty-eight (1.9%) of 2506 patients with melanoma developed additional primary melanomas. Median follow-up was 66 months. Except in one patient, the subsequent melanomas were thinner (median, 0.32 mm vs 1.50 mm; P < 0.0001). Compared with patients without MPM, patients with MPM were more likely to be older (median age, 54.5 vs 51.0 years; P = 0.048), to have superficially spreading melanomas (SSM) ( P = 0.025), to have negative sentinel lymph nodes ( P = 0.021), or to lack lymphovascular invasion (LVI) ( P = 0.008) with the initial tumor. On multivariate analysis, age ( P = 0.028), LVI ( P = 0.010), and SSM subtype of the original melanoma ( P = 0.024) were associated with MPM. Patients with MPM and patients with single primary melanoma had similar DFS (5-year DFS 88.7 vs 81.3%, P = 0.380), but patients with MPM had better OS (5-year OS 95.3 vs 80.0%, P = 0.005). Nonmelanoma malignancies occurred in 152 patients (6.1%). Ongoing surveillance of patients with melanoma is important given that a significant number will develop additional melanoma and nonmelanoma tumors. With close follow-up, second primary melanomas are usually detected at an early stage.

PATIENT WITH SQUAMOUS CELL CARCINOMA AND SECOND PRIMARY TUMOR ON THE LIPS: A CASE REPORT

2020 ◽  
Vol 130 (3) ◽  
pp. e144
Author(s):  
ANTONIA TAIANE LOPES DE MORAES ◽  
YASMIM RODRIGUES SENA ◽  
KAROLYNY MARTINS BALBINOT ◽  
BEATRIZ VOSS MARTINS ◽  
SÂMIA CORDOVIL DE ALMEIDA
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Second Primary ◽  
Second Primary Tumor

Second Primary Melanoma: Risk Factors, Histopathologic Features, Survival, and Implications for Follow-Up

2016 ◽  
Vol 82 (10) ◽  
pp. 1009-1013 ◽  
Author(s):  
Maris S. Jones ◽  
Hitoe Torisu-Itakura ◽  
Devin C. Flaherty ◽  
Hans F. Schoellhammer ◽  
Jihey Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Cutaneous Melanoma ◽  
Primary Melanoma ◽  
Second Primary ◽  
Melanoma Risk ◽  
Impact On Survival ◽  
The Impact ◽  
Histopathologic Features

The impact on survival of a second primary melanoma (SPM) is unclear. We used our melanoma center's database to examine clinicopathologic risk factors and outcomes of stage 0 to IV cutaneous melanoma in patients with one versus two primaries. Among 12,325 patients with primary melanoma, 969 (7.86%) developed SPM. SPMs were significantly thinner than autologous primary melanomas ( P = 0.01), and 451 SPM patients had better overall and melanoma-specific survival than 451 prognostically matched non-SPM patients ( P < 0.0001 and 0.0001, respectively) at a median follow-up of 142.37 months. Patients with cutaneous melanoma are at high risk for development of SPM, but the development of SPM does not seem to impair survival.

CDKN2A (INK4A-ARF) Mutation Analysis to Distinguish Cutaneous Melanoma Metastasis From a Second Primary Melanoma

2007 ◽  
Vol 31 (4) ◽  
pp. 637-641 ◽  
Author(s):  
Willeke A. M. Blokx ◽  
Joost J. Lesterhuis ◽  
Monique P. M. Andriessen ◽  
Marian A. J. Verdijk ◽  
Kees J. A. Punt ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Cutaneous Melanoma ◽  
Primary Melanoma ◽  
Second Primary ◽  
Melanoma Metastasis
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