Pigmented primary cutaneous balloon cell melanoma demonstrating balloon cells in the dermoepidermal junction: a brief case report with dermatoscopy and histopathology

2015 ◽  
Vol 55 (2) ◽  
pp. e110-e112 ◽  
Author(s):  
Mike Inskip ◽  
Nisha James ◽  
Jill Magee ◽  
Cliff Rosendahl
Keyword(s):  
Case Report ◽  
Dermoepidermal Junction ◽  
Balloon Cells ◽  
Balloon Cell

scholarly journals balloon cell melanoma: a case report with polarized and non-polarized dermatoscopy and dermatopathology

2014 ◽  
Author(s):  
James Maher ◽  
Alan Cameron ◽  
Sharon Wallace ◽  
Rafael Acosta-Rojas ◽  
Davidq Weedon ◽  
...  
Keyword(s):  
Case Report ◽  
Balloon Cell

scholarly journals Balloon Cell Malignant Melanoma in a Young Female: A Case Report and Review of the Literature

2016 ◽  
Vol 9 (1) ◽  
pp. 262-266 ◽  
Author(s):  
Yui Hattori ◽  
Kazuhiro Sentani ◽  
Takuya Hattori ◽  
Yoshimi Matsuo ◽  
Mikio Kawai ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Lymph Nodes ◽  
Immunohistochemical Analysis ◽  
Histopathological Analysis ◽  
Lumbar Region ◽  
Ki 67 ◽  
Complete Replacement ◽  
Clinical Appearance ◽  
Balloon Cells ◽  
Balloon Cell

Balloon cell malignant melanoma (BCMM) is a very rare malignant melanoma subtype. The clinical appearance of BCMM varies; it may be nodular, ulcerated, polypoid, papillomatous and often non-pigmented. The tumor cells histologically appear large, polygonal or round and contain abundant granular or vacuolated cytoplasm. We herein report the case of a 32-year-old female who presented with a focal eccentric pigmented mass in the left lumbar region of 15 mm in diameter that had been present for several years. She underwent tumor excision. The histopathological analysis showed epithelioid melanocytes with clear cytoplasm. An immunohistochemical analysis revealed that the cells were positive for HMB-45 and S-100 protein and negative for cytokeratin. The balloon cell component stained negative for Fontana-Masson. A month later, the patient underwent excision of the bilateral inguinal lymph nodes and metastatic BCMM was revealed. The lymph node metastases showed the complete replacement of lymph nodes by balloon cells. A diagnosis of BCMM (Breslow depth 10 mm, Clark level V) without ulcer was rendered. Staining with Ki-67 was positive in almost 44% of the balloon cells.

Balloon cell melanoma: a case report

1983 ◽  
Vol 108 (5) ◽  
pp. 617-619 ◽  
Author(s):  
J.J. HORTON ◽  
D.M. MacDONALD
Keyword(s):  
Case Report ◽  
Balloon Cell

Glutamate clearance mechanisms in resected cortical dysplasia

2011 ◽  
Vol 114 (4) ◽  
pp. 1195-1202 ◽  
Author(s):  
Jorge A. González-Martínez ◽  
Zhong Ying ◽  
Richard Prayson ◽  
William Bingaman ◽  
Imad Najm
Keyword(s):  
Glutamine Synthetase ◽  
Glial Fibrillary Acidic Protein ◽  
Differential Expression ◽  
Immunohistochemical Staining ◽  
Focal Epilepsy ◽  
Cortical Dysplasia ◽  
Balloon Cells ◽  
Balloon Cell ◽  
Dysplastic Neurons

Object Changes in the expression of glutamate transporters (GLTs) may play a role in the expression of epileptogenicity. Previous studies have shown an increased number of neuronal GLTs in human dysplastic neurons. The expression of glial and neuronal GLTs and glutamine synthetase (GS) in balloon cells (BCs) and BC-containing cortical dysplasia has not been studied. Methods The authors analyzed neocortical samples that were resected in 5 patients who had cortical dysplasia–induced medically intractable focal epilepsy and who underwent extraoperative prolonged electrocorticographic (ECoG) recordings. The expressions of glial (GLT1/EAAT2) and neuronal (EAAT3, EAAC1) GLTs and GS proteins were immunohistochemically studied in all 5 resected samples. The authors also assessed in situ colocalization of GLTs and GS with neuronal and glial markers. Results Balloon cell–containing cortical dysplasia lesions did not exhibit ictal patterns on prolonged extraoperative ECoG recordings. There was a differential expression of glial and neuronal GLTs in BCs and dysplastic neurons: the majority of BCs highly expressed glial but not neuronal GLTs. Dysplastic neurons showed increased immunohistochemical staining with neuronal EAAT3 but not with EAAT2/GLT1. Moreover, only glial fibrillary acidic protein–positive BCs also expressed GS. Conclusions There is a differential GLT expression in dysplastic and balloon cells. The presence of glial GLTs and GS in balloon cell cortical dysplasia suggests a possible antiepileptic role for BCs and is consistent with the reported increased epileptogenicity in GLT1-deficient animals.

Balloon cells and dysmorphic neurons in the hippocampus associated with epileptic amnesic syndrome: A case report

Epilepsia ◽  
2008 ◽  
Vol 49 (5) ◽  
pp. 905-909 ◽  
Author(s):  
Se Hoon Kim ◽  
Yang-Je Cho ◽  
Hyung Seok Kim ◽  
Kyoung Heo ◽  
Min-Cheol Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Balloon Cells ◽  
Amnesic Syndrome ◽  
Dysmorphic Neurons

scholarly journals Successful Treatment of Mucocutaneous Lupus Erythematosus in a Dog with Prednisolone, Mycophenolate Mofetil and Tacrolimus

2021 ◽  
Vol 8 (5) ◽  
pp. 72
Author(s):  
Jae-Eun Hyun ◽  
Yeong-Hun Kang ◽  
Cheol-Yong Hwang
Keyword(s):  
Mycophenolate Mofetil ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Oral Prednisolone ◽  
Intact Male ◽  
Strong Reaction ◽  
Dermoepidermal Junction ◽  
Tacrolimus Ointment ◽  
First Case ◽  
Continuous Use

A 6-year-old, intact male miniature Pinscher dog had erosive lesions on perilabial, peripenial and perianal mucocutaneous areas, which were exacerbated by ulcerations, crusts, with pain while defecating and urinating. The lesions were symmetrical, and no systemic signs were observed. Histopathological evaluation showed parakeratotic hyperkeratosis, ulceration and cell-rich lymphoplasmacytic interface dermatitis with basal keratinocyte apoptosis. Immunohistochemistry revealed strong reaction in the dermoepidermal junction against goat-canine IgG and mild-to-moderate reaction against goat-canine IgA, IgM and C3. Based on these findings, the dog was diagnosed with mucocutaneous lupus erythematosus (MCLE). Oral prednisolone 1 mg/kg twice daily, mycophenolate mofetil (MMF) 18.3 mg/kg twice daily and 0.1% tacrolimus ointment were prescribed as initial treatment. The lesions showed remarkable improvement within 4 weeks, but the dog exhibited polyuria, polydipsia and hepatomegaly with high dosage of prednisolone. Hence, the dosage of prednisolone was gradually tapered for 9 weeks and discontinued, but MMF and tacrolimus were continued. No new lesion or associated side effect was observed while reducing the MMF dose to 10 mg/kg twice daily and with continuous use of tacrolimus ointment after steroid discontinuation. In conclusion, this case report emphasizes the usefulness of MMF and tacrolimus as steroid-sparing agents in the treatment of dogs with MCLE. To the best of our knowledge, this is the first case report of MCLE that was successfully managed long-term with MMF and tacrolimus.

scholarly journals Is apoptosis involved in the development of balloon cell nevus? Suggestion from a case report

2007 ◽  
Vol 56 (6) ◽  
pp. 1069-1070 ◽  
Author(s):  
Yun Jeon Kim ◽  
You Chan Kim ◽  
Hee Young Kang
Keyword(s):  
Case Report ◽  
Balloon Cell

scholarly journals Dermoscopy Case of the Month Combined Nevus - a Case Report

2017 ◽  
Vol 9 (2) ◽  
pp. 63-65
Author(s):  
Andrija Jović ◽  
Nataša Vidović ◽  
Danijela Popović ◽  
Zorana Zlatanović ◽  
Slađana Cekić ◽  
...  
Keyword(s):  
Case Report ◽  
Skin Lesion ◽  
Female Patient ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Lumbar Region ◽  
Dermoepidermal Junction ◽  
Melanocytic Lesions ◽  
Different Types ◽  
The Right

Abstract Combined nevi are melanocytic lesions composed of two or more distinct types of melanocytic populations within the same lesion. Different types of combined nevi may form bizarrely shaped, multicolored skin lesions, making them one of the greatest melanoma mimickers. We report a 48-year-old female patient with suspicious skin lesion in the left lumbar region. Clinically, there was an oval, slightly asymmetrical lesion measuring 6 x 4 mm, showing multiple colors and shades of brown and black. A dermoscopic examination revealed a brown-bluish coloration in the right part of the lesion, while a fine pigment network with perifollicular halo was found in the left part of the lesion, suggesting the diagnosis of a combined nevus. Histological examination showed a poorly circumscribed proliferation of dendritic melanocytes in the superficial and deep dermis and proliferation of melanocytes in the dermoepidermal junction. A surgical excision of the tumor was performed, in order to confirm the dermoscopic findings. In conclusion, dermoscopy is useful in differentiating combined nevi from other melanocytic lesions.

Balloon Cell Melanoma: Case Report

2008 ◽  
Vol 32 (1) ◽  
pp. 122-122
Author(s):  
Anna Yemelyanova ◽  
Elizabeth M. Dugan
Keyword(s):  
Case Report ◽  
Balloon Cell ◽  
Melanoma Case
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