Clinicopathologic features of IgG/IgA pemphigus in comparison with classic (IgG) and IgA pemphigus

2015 ◽  
Vol 55 (4) ◽  
pp. e184-e190 ◽  
Author(s):  
Siavash Toosi ◽  
Jeffrey W. Collins ◽  
Christine M. Lohse ◽  
Michael M. Wolz ◽  
Carilyn N. Wieland ◽  
...  
Keyword(s):  
Clinicopathologic Features ◽  
Iga Pemphigus

Clinicopathologic Features of Sporadic Colorectal Cancer with MLH1/MSH2 Loss of Expression - Reduced Likelihood of Metastases

2008 ◽  
Vol 24 (3) ◽  
pp. 175 ◽  
Author(s):  
Ji Won Park ◽  
Hee Jin Chang ◽  
Kyung Hae Jung ◽  
Dae Yong Kim ◽  
Dae Kyung Sohn ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sporadic Colorectal Cancer ◽  
Clinicopathologic Features

scholarly journals Bladder Cancer Involving Smooth Muscle of Indeterminate Type or Muscularis Mucosae in Transurethral Biopsy Specimens

2020 ◽  
Vol 154 (2) ◽  
pp. 208-214
Author(s):  
Michael J Hwang ◽  
Ashish M Kamat ◽  
Colin P Dinney ◽  
Bogdan Czerniak ◽  
Charles C Guo
Keyword(s):  
Overall Survival ◽  
Bladder Cancer ◽  
Smooth Muscle ◽  
Clinical Outcome ◽  
Survival Time ◽  
Transurethral Resection ◽  
Muscularis Propria ◽  
Clinicopathologic Features ◽  
Muscularis Mucosae ◽  
Biopsy Specimens

Abstract Objectives Bladder cancers invading the muscularis mucosae (MM) are treated differently from those invading the muscularis propria (MP). However, it may be difficult to determine the type of smooth muscle in transurethral resection (TUR) or biopsy specimens. We aimed to investigate the clinicopathologic features of bladder cancers involving smooth muscle of indeterminate type (SMIT) in TUR specimens in comparison with those invading the MM. Methods We identified 103 patients with bladder cancer involving SMIT (n = 27) or the MM (n = 76) in TUR specimens. All patients underwent subsequent restaging TUR or cystectomy. Results Bladder cancer with SMIT invasion showed a significantly higher rate of MP invasion in the subsequent specimens than those invading the MM (52% vs 29%). Lack of MP in the TUR specimens had a significantly higher risk of MP invasion in the subsequent specimens than those with the MP (61% vs 40%). The overall survival time for patients with SMIT invasion was significantly shorter than those with MM invasion. Conclusions Bladder cancers with SMIT invasion in TUR specimens show more frequent cancer upstaging in the subsequent specimens and a poorer clinical outcome than those invading the MM, which highlights the importance of a cancer restaging procedure for these patients.

Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma

2021 ◽  
Author(s):  
Carlos N. Prieto-Granada ◽  
Bin Xu ◽  
Bayan Alzumaili ◽  
Mohamed Rizwan Haroon Al Rasheed ◽  
Antoine Eskander ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Clinicopathologic Features

scholarly journals Clinicopathologic features of forehead prayer marks in Kano, Northwest Nigeria

2021 ◽  
Vol 2 ◽  
pp. 100048
Author(s):  
Kelvin U. Omeje ◽  
Bamidele A. Famurewa ◽  
Rafael A. Adebola ◽  
Rowland Agbara ◽  
Olushola I. Amole ◽  
...  
Keyword(s):  
Clinicopathologic Features

scholarly journals TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features

2021 ◽  
Vol 147 (4) ◽  
pp. 1125-1135
Author(s):  
Sang Kyum Kim ◽  
Jang-Hee Kim ◽  
Jae Ho Han ◽  
Nam Hoon Cho ◽  
Se Joong Kim ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Malignant Neoplasm ◽  
Clinicopathologic Features ◽  
Ki 67 ◽  
Tissue Samples ◽  
Formalin Fixed Paraffin ◽  
Tert Promoter Mutations ◽  
Formalin Fixed Paraffin Embedded ◽  
Penile Squamous Cell Carcinoma ◽  
Promoter Mutations

Abstract Purpose Penile carcinoma is a rare malignant neoplasm with a largely unknown molecular pathogenesis. Telomerase reverse transcriptase promoter (TERT-p) mutations have been detected in several types of human malignancies. The aim of this study was to investigate the presence of TERT-p mutations in penile squamous cell carcinomas (SCCs) and their associations with clinicopathologic features. Methods In this retrospective study, Sanger sequencing was performed to detect TERT-p mutations in formalin-fixed paraffin-embedded tissue samples from 37 patients with penile SCC, 16 patients with cutaneous SCC, and 4 patients with non-neoplastic penile/skin tissue. The expression of p16INK4a and Ki-67 was investigated via immunohistochemistry. Associations of TERT-p mutation with clinicopathological factors, immunohistochemical results, and clinical outcome were statistically analyzed. Results Recurrent TERT-p mutations were identified in 18 out of 37 (48.6%) penile SCCs, including all 3 carcinoma in situ cases. TERT-p mutations were significantly more frequent in non-human papilloma virus (HPV)-related penile SCC types than in non-HPV-related penile SCC based on both histologic classification and p16INK4a immunoreactivity. Furthermore, TERT-p mutation was associated with a low histologic grade, low mitotic count, absence of necrosis, low Ki-67/MIB-1 labeling index, and absence of lymph node or distant metastasis. Conclusion Our study shows TERT-p mutations are the most frequent somatic mutations in penile SCC. In addition, TERT-p mutations are far more frequent in non-HPV-related penile SCC than in HPV-related penile SCC, indicating TERT-p mutations may have a role in tumorigenesis distinct from HPV-related penile SCC.

The impact of MYC amplification on clinicopathologic features and prognosis of radiation‐associated angiosarcomas of the breast

2021 ◽  
Author(s):  
M Gabriela Kuba ◽  
Bin Xu ◽  
Sandra P D’Angelo ◽  
Evan Rosenbaum ◽  
George Plitas ◽  
...  
Keyword(s):  
Clinicopathologic Features ◽  
The Impact
Sign in / Sign up

Export Citation Format

Share Document