scholarly journals The effect of low dose ketamine on postoperative quality of recovery in patients undergoing breast cancer surgery: a randomized, placebo‐controlled trial

2021 ◽  
Author(s):  
Zi‐Jian Zhao ◽  
Qi‐Qi Xu ◽  
Yao Chen ◽  
Chen Liu ◽  
Fang‐Fang Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Low Dose ◽  
Controlled Trial ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Quality Of Recovery ◽  
Postoperative Quality

The effect of low dose ketamine on postoperative quality of recovery in patients undergoing breast cancer surgery: a randomized, placebo controlled trial

2019 ◽  
Author(s):  
Yuan Han ◽  
Zijian Zhao ◽  
Qiqi Xu ◽  
Yao Chen ◽  
Chen Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Normal Saline ◽  
Low Dose ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Control Group ◽  
Quality Of Recovery ◽  
Safety Outcomes ◽  
Postoperative Quality

Abstract Background: Intraoperative low dose ketamine has been widely studied for postoperative multimodal analgesia. However, the effect of low dose ketamine on postoperative quality of recovery in female patients undergoing breast cancer surgery has not been studied. The primary aim of this study was to assess the effects of low dose ketamine on postoperative quality of recovery in these patients using the 40-Item Quality of Recovery (QoR-40) scale. The second aim of this study was to evaluate the effects of intraoperative infusion of low-dose ketamine on chronic postoperative surgical pain (CPSP). Methods: In this prospective, randomized, double-blind trial, 100 patients planned for modified radial mastectomy were randomly assigned to one of two groups: control group (group C) and ketamine group (group K). After induction of anesthesia and before surgical incision, a bolus dose of 0.5 mg/kg ketamine or an equivalent volume of normal saline was injected followed by 0.25 mg/kg/h ketamine or normal saline infusions until skin closure. Postoperative recovery profiles, including the QoR-40 scores on postoperative day 1, numeric rating scale (NRS), and douleur neuropathique 4 (DN-4) questionnaire at postoperative month 3 were evaluated. In addition, patient characteristics, perioperative parameters, and safety outcomes were assessed. Results: Global QoR-40 scores on postoperative day 1 were not significantly different between both groups (p = 0.139). Of the five dimensions, emotional state and pain scores were significantly higher in group K than in group C (p = 0.044 and 0.023, respectively). At postoperative month 3, CPSP and neuropathic pain (NP) were not significantly different between groups (p = 0.259 and 0.959, respectively). The incidence of safety outcomes were similar between groups. Conclusion: Low dose ketamine did not improve overall quality of recovery or chronic pain in patients undergoing breast cancer surgery.

The Choice for Breast Cancer Surgery: Can Women Accurately Predict Postoperative Quality of Life and Disease-Related Stigma?

2011 ◽  
Vol 18 (9) ◽  
pp. 2477-2482 ◽  
Author(s):  
Jennifer F. Waljee ◽  
Peter A. Ubel ◽  
Dunya M. Atisha ◽  
Emily S. Hu ◽  
Amy K. Alderman
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Related Stigma ◽  
Postoperative Quality

Impact of pectoral nerve block on postoperative pain and quality of recovery in patients undergoing breast cancer surgery

2018 ◽  
Vol 35 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Yoshinori Kamiya ◽  
Miki Hasegawa ◽  
Takayuki Yoshida ◽  
Misako Takamatsu ◽  
Yu Koyama
Keyword(s):  
Breast Cancer ◽  
Postoperative Pain ◽  
Nerve Block ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Quality Of Recovery ◽  
Pectoral Nerve

scholarly journals Thoracic Paravertebral Blockade Reduces Chronic Postsurgical Pain in Breast Cancer Patients: A Randomized Controlled Trial

Pain Medicine ◽  
2020 ◽  
Vol 21 (12) ◽  
pp. 3539-3547
Author(s):  
Zeng-Mao Lin ◽  
Mu-Han Li ◽  
Feng Zhang ◽  
Xue Li ◽  
Chun-Li Shao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Neuropathic Pain ◽  
Controlled Trial ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Control Group ◽  
Single Shot ◽  
Randomized Controlled ◽  
Chronic Postsurgical Pain

Abstract Objective To evaluate the effect of multilevel single-shot thoracic paravertebral blockade (PVB) on the occurrence of chronic postsurgical pain (CPSP) in patients undergoing breast cancer surgery. Design A randomized controlled trial with two parallel groups. Setting A tertiary hospital. Methods Patients scheduled for breast cancer surgery were randomized to receive either ultrasound-guided multilevel single-shot PVB from T2 to T5 (the PVB group) or nothing (the control group). Surgery was then performed under general anesthesia. Patients were followed up for 12 months after surgery. The primary end point was incidence of CPSP at six months after surgery. Results A total of 218 patients were enrolled and randomized; of these, 208 and 204 completed six- and 12-month follow-up, respectively. The incidence of CPSP at six months was significantly lower in the PVB group (12.5% [13/104]) than in the control group (24.0% [25/104], relative risk = 0.52, 95% CI = 0.28–0.96, P = 0.031). Pain scores within 48 hours both at rest and with movement were lower in the PVB group than the control group (P = 0.006 and P < 0.001, respectively). The percentages of patients with neuropathic pain were also lower in the PVB group than the control group at both six and 12 months after surgery (P = 0.016 and 0.028, respectively). Adverse events did not differ between groups. Conclusions For patients undergoing breast cancer surgery, multilevel single-shot PVB reduces the incidence of CPSP at six months; it also improves early postoperative analgesia and reduces neuropathic pain at six and 12 months after surgery.

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