Relationships between Obstructive Sleep Apnea Syndrome and cardiovascular risk in a naïve population of southern Italy

2021 ◽  
Author(s):  
Pierluigi Carratù ◽  
Agostino Di Ciaula ◽  
Silvano Dragonieri ◽  
Teresa Ranieri ◽  
Marco Matteo Ciccone ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Southern Italy ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Evaluation of endothelial function and cardiovascular risk in non-obese patients with slight degree of obstructive sleep apnea syndrome

2017 ◽  
Vol 87 (3) ◽  
Author(s):  
Fiorella Devito ◽  
Annapaola Zito ◽  
Silvano Dragonieri ◽  
Pierluigi Carratù ◽  
Vitaliano N. Quaranta ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Intima Media Thickness ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5±11.5 years), of which 16 with mild OSAS and 16 snoring without OSAS. Mild OSAS is defined by an AHI index between 5 and 15. We have investigated if whether there was a relationship between mild OSAS, endothelial function and carotid intima-media thickness (C-IMT). The population was divided into two groups: Group 1 (16 simple snorer patients with an average age of 39.4±12.1 years) and Group 2 (16 subjects with mild OSAS with an average age of 39.6±11.2 years). Each group underwent cardiovascular investigation including measurement of flow-mediated dilation (FMD) of the brachial artery and C-IMT. Both groups comprised non-obese subjects. Patients with mild OSAS had serum total cholesterol values statistically significantly higher than simple snores patients (178.6±24.9 vs 159.2±25.3; p=0.038). OSAS patients had also a trend towards higher values of maximum C-IMT compared to simple snorer patients (0.70±0.15 vs 0.65±0.16), although below the level of significance. Between the two groups, no difference was found for FMD values. The present results on mild OSAS strengthen the importance of a diagnosis of OSAS as soon as possible, in order to encourage all primary prevention interventions to correct risk factors responsible for disease progression and the occurrence of cardiovascular diseases, not excluding the use of therapies of non-invasive ventilation even in the early stages of the disease.

Sex-Related Differences in Polygraphic Parameters in a Population of Patients with Obstructive Sleep Apnea Syndrome

2021 ◽  
Vol 20 ◽  
Author(s):  
Laura Buratti ◽  
Chiara Rocchi ◽  
Viviana Totaro ◽  
Serena Broggi ◽  
Simona Lattanzi ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Men And Women ◽  
Autonomic Changes ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background: Sex-related differences in the prevalence and clinical presentation of Obstructive Sleep Apnea Syndrome (OSAS) have been widely documented. The aim of this study was to investigate the influence of patients’ sex on polygraphic parameters with particular attention to sleep autonomic changes in a population of OSAS patients. Methods: Sixty OSAS patients aged 55-65 years (30 men, 30 women) were enrolled. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and daytime sleepiness with the Epworth Sleepiness Scale (ESS). The presence of respiratory events and autonomic changes during the night was investigated by polygraphy. Results : Similar main cardiovascular risk factors prevalence was observed in both men and women. We observed a significant difference in PSQI (higher in women, p=0.0001) and ESS (higher in men, p=0.004) scores. Snoring (p=0.033), supine AHI (p=0.004), T90 (p=0.021), LO2 (p=0.0001), LF/HF ratio and LF (p=0.0001) were significantly higher in men. Sex differences in PSQI mean score and LF/HF ratio variability were preserved in all the subgroups of OSA severity. Conclusion: The influence of sex in modulating cardiovascular risk is a widely discussed topic. In our study, men showed more severe polygraphic parameters and an increase in LF/HF ratio compared to women. The results of our investigation suggest the relevance of delivering information about the different expressions of OSAS in men and women in order to improve diagnostic skills and in-depth prevention approaches.

scholarly journals Aortic Pressure Augmentation as a Marker of Cardiovascular Risk in Obstructive Sleep Apnea Syndrome

2008 ◽  
Vol 31 (6) ◽  
pp. 1109-1114 ◽  
Author(s):  
Akiko NODA ◽  
Seiichi NAKATA ◽  
Hiroshi FUKATSU ◽  
Yoshinari YASUDA ◽  
Etsuko MIYAO ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Aortic Pressure ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals OBSTRUCTIVE SLEEP APNEA SYNDROME AS CARDIOVASCULAR RISK FACTOR ASSOCIATED WITH HYPERURICEMIA

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e397-e398
Author(s):  
Ruth Skvortsova ◽  
Kristina Anisimova ◽  
Viktoria Pavlova ◽  
Anna Obukhova ◽  
Kristina Popova ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Cardiovascular Risk Factor ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Pathophysiologic Mechanisms of Cardiovascular Disease in Obstructive Sleep Apnea Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Carlos Zamarrón ◽  
Luis Valdés Cuadrado ◽  
Rodolfo Álvarez-Sala
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Metabolic Effects ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder, characterized by repeated disruptions of breathing during sleep. This disease has many potential consequences including excessive daytime sleepiness, neurocognitive deterioration, endocrinologic and metabolic effects, and decreased quality of life. Patients with OSAS experience repetitive episodes of hypoxia and reoxygenation during transient cessation of breathing that provoke systemic effects. Furthermore, there may be increased levels of biomarkers linked to endocrine-metabolic and cardiovascular alterations. Epidemiological studies have identified OSAS as an independent comorbid factor in cardiovascular and cerebrovascular diseases, and physiopathological links may exist with onset and progression of heart failure. In addition, OSAS is associated with other disorders and comorbidities which worsen cardiovascular consequences, such as obesity, diabetes, and metabolic syndrome. Metabolic syndrome is an emerging public health problem that represents a constellation of cardiovascular risk factors. Both OSAS and metabolic syndrome may exert negative synergistic effects on the cardiovascular system through multiple mechanisms (e.g., hypoxemia, sleep disruption, activation of the sympathetic nervous system, and inflammatory activation). It has been found that CPAP therapy for OSAS provides an objective improvement in symptoms and cardiac function, decreases cardiovascular risk, improves insulin sensitivity, and normalises biomarkers. OSAS contributes to the pathogenesis of cardiovascular disease independently and by interaction with comorbidities. The present review focuses on indirect and direct evidence regarding mechanisms implicated in cardiovascular disease among OSAS patients.

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