scholarly journals Hepatoprotective effects of metformin in hepatitis C virus‐infected adolescents with beta thalassaemia major

2021 ◽  
Vol 75 (12) ◽  
Author(s):  
Ali Talebi ◽  
Mona Kargar
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Thalassaemia Major ◽  
Beta Thalassaemia ◽  
Hepatoprotective Effects

scholarly journals FREQUENCY OF HEPATITIS B AND HEPATITIS C IN MULTITRANSFUSED BETA THALASSAEMIA MAJOR PATIENTS IN DISTRICT SWAT

1969 ◽  
Vol 3 (2) ◽  
pp. 299-302
Author(s):  
IMRAN UD DIN KHATTAK ◽  
MUKAMIL SHAH ◽  
IMTIAZ AHMED ◽  
AMIR REHMAN ◽  
MOHAMMAD SAJID
Keyword(s):  
Hepatitis C ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Care Center ◽  
Autosomal Recessive Disorder ◽  
Beta Thalassemia ◽  
Enzyme Linked Immunosorbent Assay ◽  
Thalassaemia Major ◽  
Beta Thalassaemia

BACKGROUND: Beta thalassaemia major is the commonest inherited as autosomal recessive disorder inPakistan. Almost all patients beta thalassaemia major require blood transfusion within the first two years oflife to prevent severe anaemia and its physical consequences. Due to repeated blood transfusions hepatitis Band hepatitis C infections can occur in these patients. To document the prevalence and frequency of hepatitisB & hepatitis C in multi transfused beta Thalassemia major patients in our set up.STUDY DESIGN:Aprospective descriptive study.PLACE AND DURATION OF STUDY: The study was conducted in thalassaemia care center A1 FajarFoundation Blood Transfusion ServicesSwat from 1-1-2012 to 31-12-2012.PATIENTS AND METHODS: Study was carried on 170 multi transfused thalassaemia major patientswho were registered with A1 Fajar Foundation Swat, irrespective of age, sex, time of diagnosis. Only thosepatients were included in the study who had received so far more than 10 transfusions. They were screenedfor hepatitis B and C by Enzyme Linked Immunosorbent Assay (ELISA). The subjects were in the agesrange of 2-15 year,with 94 (55.29%) male and 76 (94:71%) female.RESULTS: Out of these 10 patients (5.88%) were found to have hepatitis B surface antigen (HBsAg)positive and 37 patients (21.76%) hepatitis C virus(HCV) antibody positive.CONCLUSION: In spite of the fact that screened blood is used for transfusions, still a large number ofpatients have been found infected with hepatitis B and C. It has been recommended that properly screenedbloods using a reliable and accurate method are used for screening of blood to prevent transfusiontransmitted diseases. It can be avoided by giving screened safe blood.KEYWORDS: Hepatitis B, Hepatitis C,Thalassaemia Major,Transfusion

Prevalence of Hepatitis C Virus Infection among β-Thalassaemia Major Patients

1997 ◽  
Vol 27 (2) ◽  
pp. 105-105 ◽  
Author(s):  
Syed Abdul Mujeeb ◽  
Mubashir Ahmed Shiekh ◽  
Rafique Khanani ◽  
Qamar Jamal
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Thalassaemia Major ◽  
Hepatitis C Virus Infection

Chronic hepatitis C virus infection without cirrhosis induces insulin resistance in patients with β-thalassaemia major

2001 ◽  
Vol 13 (10) ◽  
pp. 1195-1199 ◽  
Author(s):  
Maria Sougleri ◽  
Cryssoula Labropoulou-Karatza ◽  
Panagiota Paraskevopoulou ◽  
Helen Fragopanagou ◽  
Theodoros Alexandrides
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Thalassaemia Major ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

scholarly journals Hepatitis C virus distribution and clearance following interferon-monotherapy among thalassaemia major and intermedia patients

2011 ◽  
Vol 155 (4) ◽  
pp. 524-527 ◽  
Author(s):  
Paolo Ricchi ◽  
Alfonso G. Lanza ◽  
Massimiliano Ammirabile ◽  
Silvia Costantini ◽  
Patrizia Cinque ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Thalassaemia Major ◽  
Interferon Monotherapy ◽  
Virus Distribution

scholarly journals Antibody to hepatitis C virus in multiply transfused patients with thalassaemia major.

1990 ◽  
Vol 43 (8) ◽  
pp. 638-640 ◽  
Author(s):  
B Wonke ◽  
A V Hoffbrand ◽  
D Brown ◽  
G Dusheiko
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Thalassaemia Major

scholarly journals Prevalence of Hepatitis C Virus Infection in Multi-transfused Thalassaemia Patients in Bangladesh

2018 ◽  
Vol 8 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Belayet Hossain ◽  
Selimuzzaman ◽  
WA Khan ◽  
Muhammad Tawfique ◽  
Fazlur Rahman
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Cross Sectional Study ◽  
Hereditary Diseases ◽  
Thalassaemia Major ◽  
Hepatitis C Virus Infection ◽  
Cross Sectional ◽  
Hb E ◽  
Blood Specimens

Background: Thalassaemia is one of the most common hereditary diseases worldwide including Bangladesh. Multitransfused thalassaemia patients may acquire hepatitis C virus infection in spite of currently practicing screening schedule. It is postulated that there are some pitfalls in the currently practicing screening system behind the transmission of HCV in transfusion-dependent thalassaemia patients.Objectives: To find out the prevalence of hepatitis C virus infection in transfusiondependent thalassaemia patients and thereby to see the efficacy of currently practicing screening schedule for hepatitis C virus.Materials and Methods: This cross-sectional study was conducted from 1st December, 2015 to 30th November, 2016 at Dhaka Shishu (Children) Hospital Thalassemia Center (DSHTC). Three hundred and twenty patients of multitransfused β-thalassaemia major and Hb E β-thalassaemia aged 3−18 years were enrolled. History was taken and physical examination was done. Blood specimens were collected and sent to the standard laboratory for detection of antibody against hepatits C virus.Results: Among the subjects, 174 (54.3%) were male and 146 (45.7%) were female. Out of total 320 patients, 75 (23%) were β-thalassaemia major and 245 (77%) were Hb E β-thalassaemia. Among the 320 thalassaemia cases, 47 were found positive for anti-HCV with an overall prevalence of 14.7%.Conclusion: Despite screening of blood donors by Rapid Device (Strip) Method, HCV infection remains an important cause of viral hepatitis infection among multitransfused thalassaemia children.J Enam Med Col 2018; 8(1): 16-19

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