scholarly journals Oxidative stress and schizophrenia: A comparative cross‐sectional study of multiple oxidative markers in patients and their first‐degree relatives

2021 ◽  
Author(s):  
Eray Metin Guler ◽  
Ayse Kurtulmus ◽  
Ayse Zehra Gul ◽  
Abdurrahim Kocyigit ◽  
Ismet Kirpinar
Keyword(s):  
Oxidative Stress ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
First Degree Relatives ◽  
Oxidative Markers

scholarly journals Oxidative stress and schizophrenia: A comparative cross-sectional study of multiple oxidative markers in patients and their first-degree relatives

2021 ◽  
Author(s):  
Eray Guler ◽  
Ayse Kurtulmus Calis ◽  
Ayse Zehra Gul ◽  
Abdurrahim Kocyigit ◽  
Ismet Kirpinar
Keyword(s):  
Oxidative Stress ◽  
Severity Of Illness ◽  
Total Antioxidant Status ◽  
Cross Sectional Study ◽  
Stress Index ◽  
Cross Sectional ◽  
First Degree Relatives ◽  
Oxidative Markers ◽  
Total Antioxidant ◽  
Mathematical Formulas

Objective: Schizophrenia(SCZ) is a heritable severe mental disorder with unknown pathogenic mechanisms. It is known that oxidative stress(OS) plays a crucial role in the pathophysiology of SCZ. Our study aimed to evaluate whether there is a relationship between the severity of illness and OS biomarkers in SCZ patients and first-degree-relatives of patients(FDRs). Methods: This study included 50 adult patients with SCZ, 50 unaffected FDRs, and 50 controls. OS biomarkers, myeloperoxidase(MPO), total oxidant status(TOS), total antioxidant status(TAS), total thiol(TT), and native thiol(NT) levels were measured by different photometric methods. Disulfide(DS) and oxidative stress index(OSI) were calculated with mathematical formulas. Results: TOS, DS, and OSI levels were significantly higher, and TAS, TT, and NT levels were lower in SCZ and FDRs than controls. In SCZ group, MPO activity was higher compared to relatives and controls. Results in this study did not provide a strong correlation between Positive&Negative Syndrome Scale(PANSS) and other biomarkers. There was just a low negative correlation between TT and PANSS in SCZ group(p=0,041,r=-0,297). Conclusion: OS increased significantly in SCZ, and FDRs increased slightly than controls, indicating the presence of OS in the etiology of the disease. High OS may be an effective factor for SCZ in later years.

scholarly journals Malondialdehyde Levels in Preeclampsia before and after Delivery

1970 ◽  
pp. 143
Author(s):  
Harold Rumopa ◽  
Freddy W. Wagey ◽  
Eddy Suparman
Keyword(s):  
Oxidative Stress ◽  
Plasma Levels ◽  
Cross Sectional Study ◽  
Hplc Method ◽  
Wilcoxon Test ◽  
Sectional Study ◽  
Cross Sectional ◽  
Average Value ◽  
Significant Difference ◽  
Before And After

  Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery.   Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory.   Results: In patients with severe preeclampsia before deliverywe found average value (1.4796  0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000).   Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress.   Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia

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