Evaluation of the role of Chlamydia trachomatis in primary male infertility

2021 ◽  
Author(s):  
Asmaa Nasr El‐din ◽  
Hadeer Sorour ◽  
Mona Fattouh ◽  
Mohammed Abu El‐Hamd
Keyword(s):  
Chlamydia Trachomatis ◽  
Male Infertility ◽  
Primary Male

The role of Chlamydia trachomatis infection in male infertility

2009 ◽  
Vol 91 (4) ◽  
pp. 1448-1450 ◽  
Author(s):  
Päivi Joki-Korpela ◽  
Niina Sahrakorpi ◽  
Mervi Halttunen ◽  
Heljä-Marja Surcel ◽  
Jorma Paavonen ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Male Infertility ◽  
Chlamydia Trachomatis Infection

scholarly journals The Role of Chlamydia trachomatis in Male Infertility

Chlamydia ◽  
10.5772/29774 ◽  
2012 ◽  
Author(s):  
Gilberto Jaramillo-Rangel ◽  
Guadalupe Gallegos-Avila ◽  
Benito Ramos-Gonzalez ◽  
Salomon Alvarez-Cuevas ◽  
Andres M. ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Male Infertility

THE ROLE OF UROGENITAL INFECTIONS IN THE PATHOGENESIS OF THE DEVELOPMENT OF MALE INFERTILITY

Vestnik ◽  
2021 ◽  
pp. 161-165
Author(s):  
Ж. Инкарбек ◽  
Ж. Турсынбеков ◽  
Е. Чакен ◽  
А.Х. Касымов ◽  
С.Б. Шалекенов
Keyword(s):  
Chlamydia Trachomatis ◽  
Male Infertility ◽  
Diagnostic Methods ◽  
Urogenital Tract ◽  
World Health ◽  
Urogenital Infection ◽  
Urogenital Infections ◽  
The World ◽  
Tract Infections

Вопрос бесплодия на сегодняшний день остается актуальным как в Казахстане, так и во всем мире. На основании данных Всемирной Организации Здравоохранения, ежегодно число бесплодных пар составляет 4-5% от всеобщей популяции. Причин бесплодия - множество. Но одним из острых и первоочередных причин данной патологии является мужское бесплодие, частота возникновения которого составляет 48,8% от общего количества случаев. [1] По данным мировых исследований, в процентном соотношении причины мужского бесплодия составляют: бесплодие неясного генеза - 31,2%, варикоцеле - 14,7%, эндокринные нарушения - 8,45%, инфекции урогенитального тракта - 8,3%, иммунологические факторы - 4,8%, опухоли яичек - 1,17%. [2] The issue of infertility today remains relevant both in Kazakhstan and around the world. The World Health Organization accounts for 4-5% of the general population annually. There are many reasons for infertility. One of the acute and primary causes of this pathology is male infertility, the incidence of which is 48.8% of the total number of cases. According to world studies, the percentage of the causes of male infertility are: infertility of unknown origin - 31.2%, varicocele - 14.7%, endocrine disorders - 8.45%, infections of the urogenital tract - 8.3%, immunological factors - 4 , 8%, testicular tumors - 1.17%. Goal. Establishing the role of individual infections and their association of the urogenital tract in the development of male infertility. Materials and methods. The study was carried out on the basis of the GKP on the REM "City polyclinic No. 26" in Almaty. A retrospective analysis of individual cards of 538 men from 21 to 45 years old who consulted urologists with complaints of urination, pain and discomfort in the anogenital region and above the bosom from January to December 2020 was carried out. The patients were divided into two groups: the first group - 258 men suffering from infertility, and who have other causes of infertility, the second - 280 men with normal fertility. Diagnostic methods were selected: bacterial culture of urine and scraping from the urethra, PCR of urogenital infections. Result: The total dissemination of the urethra in patients of the first group is 3 times higher than in men of the second group. However, we were interested not only in the general dissemination and types of pathogens, as according to the literature [1,2] the most aggressive chlamydia trachomatis and ureoplasm. In our frequency of occurrence of chlamydial infection in both groups was 153 (59.3%) and 23 (8%); mycoplasma - 148 (57.3%) and 45 (16%); ureaplasma - 137 (53.1%) and 63 (22.5%); Candida - 98 (37.9%) and 35 (12.5%); Trichomonas - 87 (33.7%) and 48 (17.1%); gardnerella - 94 (36.4%) and 56 (20%) people, respectively. Conclusions. Urogenital tract infections are the main reason people see a doctor. Infections are one of the factors in the development of infertility in men. For infection of the urogenital tract, PCR is the most sensitive and accurate compared to urine culture and urethral scrapings. The total dissemination of urogenital infection in the group of men with infertility is 46.3%, in comparison with the group of men with a normal norm in whom the percentage of STIs is 16%, indicates a direct effect of urogenital infection on the development of the male population. Along with the revealed, as the main factor of influence of the reproductive system, chlamydia trachomatis 59.3%, mycoplasma 57.3%, ureoplasm 53.1%, which moved to the second and third place in the development of infertility in the studied men. This factor and methods of treatment will be studied in studies.

The Role of Anogenital Distance Measurement in the Prediction of The Efficacy of Varicocelectomy in Primary Male Infertility

2019 ◽  
Vol 87 (12) ◽  
pp. 5315-5321
Author(s):  
ABD ELRAHMAN W. BEDAIR, M.Sc.; AHMED F. GHAITH, M.D. ◽  
KHALID A. SALEM, M.D.; AYMAN A. HASSAN, M.D.
Keyword(s):  
Male Infertility ◽  
Distance Measurement ◽  
Anogenital Distance ◽  
Primary Male

The Effect of PDE5 Inhibitors on the Male Reproductive Tract

2020 ◽  
Vol 26 ◽  
Author(s):  
Nikolaos Sofikitis ◽  
Aris Kaltsas ◽  
Fotios Dimitriadis ◽  
Jens Rassweiler ◽  
Nikolaos Grivas ◽  
...  
Keyword(s):  
Male Infertility ◽  
Reproductive Tract ◽  
Tunica Albuginea ◽  
Scientific Data ◽  
Secretory Function ◽  
Pde5 Inhibitors ◽  
Male Reproductive Tract ◽  
Review Study ◽  
Phosphodiesterase 5

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance the prostatic secretory function leading to an improvement in sperm motility. Other studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Placebo-controlled, randomized, blind studies are necessary to unambiguously incorporate PDE5 inhibitors as an adjunct tool for the pharmaceutical treatment of semen disorders and male infertility.

scholarly journals Regulatory Role of Sex Hormones in Cardiovascular Calcification

2021 ◽  
Vol 22 (9) ◽  
pp. 4620
Author(s):  
Holly J. Woodward ◽  
Dongxing Zhu ◽  
Patrick W. F. Hadoke ◽  
Victoria E. MacRae
Keyword(s):  
Cardiovascular Disease ◽  
Sex Differences ◽  
Sexual Dimorphism ◽  
Aortic Stenosis ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Increased Risk ◽  
Male Sex ◽  
Primary Male

Sex differences in cardiovascular disease (CVD), including aortic stenosis, atherosclerosis and cardiovascular calcification, are well documented. High levels of testosterone, the primary male sex hormone, are associated with increased risk of cardiovascular calcification, whilst estrogen, the primary female sex hormone, is considered cardioprotective. Current understanding of sexual dimorphism in cardiovascular calcification is still very limited. This review assesses the evidence that the actions of sex hormones influence the development of cardiovascular calcification. We address the current question of whether sex hormones could play a role in the sexual dimorphism seen in cardiovascular calcification, by discussing potential mechanisms of actions of sex hormones and evidence in pre-clinical research. More advanced investigations and understanding of sex hormones in calcification could provide a better translational outcome for those suffering with cardiovascular calcification.

Possible role of Chlamydia trachomatis in the male partner of infertile couples

2012 ◽  
Vol 22 (3) ◽  
pp. 421-424 ◽  
Author(s):  
Zahra Noruziyan ◽  
Rasoul Roghanian ◽  
Saeid Hosseinzadeh ◽  
Nasser Golbang ◽  
Mohammad Hossein Nasr Esfahani
Keyword(s):  
Chlamydia Trachomatis ◽  
Male Partner ◽  
Infertile Couples

scholarly journals Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice

2021 ◽  
Author(s):  
Chaofeng Tu ◽  
Jiangshan Cong ◽  
Qianjun Zhang ◽  
Xiaojin He ◽  
Rui Zheng ◽  
...  
Keyword(s):  
Male Infertility ◽  
Primary Male

scholarly journals Chlamydia trachomatis and urogenital mycoplasms in nonconococcal urethirits in men

2010 ◽  
Vol 63 (1-2) ◽  
pp. 47-50
Author(s):  
Sonja Vesic ◽  
Jelica Vukicevic ◽  
Eleonora Gvozdenovic ◽  
Dusan Skiljevic ◽  
Slobodanka Janosevic ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Ureaplasma Urealyticum ◽  
Mycoplasma Hominis ◽  
Sexually Active ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Nongonococcal Urethritis ◽  
Etiological Agents ◽  
The One

Introduction. Nongonococcal urethritis is the most common sexually transmitted infection in men, with vast majority of the etiological agents such as Chlamydia trachomatis, followed by urogenital mycoplasmas. The aim of this study was to determine the prevalence of Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis in nongonococcal urethritis in men, and to examine infections associated with these agents. Material and methods. 299 sexually active, heterosexual men with nongonococcal urethritis were included into the study. Urethral samples were taken with a dacron swab placed into the urethra up to 2-3 cm. The Direct immunojluorescence tehnique was performed for identification of Chlamydia trachomatis. Ureaplasma urealyticum and Mycoplasma hominis were detected with Mycoplasma 1ST assay. Results. Chlamydia trachomatis was detected in 22.75%, Uraeplasma urealyticum in 21.08% and Mycoplasma hominis in 8.02% cases. We found no significant differences in prevalence between Chlamydia trachomatis and Ureaplasma urealyticym (p>0.05). Monoinjections were found in 51.85% with significantly higher rate (p<0.01) than associated infections (11.70%). Among associated infections, coinfection of Chlamydia trahomatis and Ureaplasma urealyticum was predominant. Association of Chlamydia trachomatis with urogenital mycoplasmas was significantly higher (p<0.05) than the one between Ureaplasma urealyticum and Mycoplasma hominis. In 36.45% patients no patogenic microorganisms were detected. Conclusion. These results confirmed the etiological role of Chlamydia trachomatis and urogenital mycoplasmas in nongonococcal urethritis with prevalence of 51.85% in monoinfections and 11.70% in associated infections. In 36.45% of cases the etiology of urethritis was not elucidated. These results suggest that more sensitive diagnostic tool should be applied when searching for the detailed etiology of nongonococcal urethritis.

The role of Chlamydia trachomatis in prostatitis

2002 ◽  
Vol 19 (6) ◽  
pp. 466-470 ◽  
Author(s):  
W. Weidner ◽  
Th. Diemer ◽  
P. Huwe ◽  
H. Rainer ◽  
M. Ludwig
Keyword(s):  
Chlamydia Trachomatis
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