The role of lactate dehydrogenase‐to‐albumin ratio in clinical evaluation of adult‐onset Still’s disease

2021 ◽  
Author(s):  
Andac Komac ◽  
Neslihan Gokcen ◽  
Ayten Yazici ◽  
Ayse Cefle
Keyword(s):  
Lactate Dehydrogenase ◽  
Clinical Evaluation ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Albumin Ratio ◽  
Still's Disease ◽  
Adult Onset Still's Disease

scholarly journals An Update on the Pathogenic Role of Neutrophils in Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still’s Disease

2021 ◽  
Vol 22 (23) ◽  
pp. 13038
Author(s):  
Ji-Won Kim ◽  
Mi-Hyun Ahn ◽  
Ju-Yang Jung ◽  
Chang-Hee Suh ◽  
Hyoun-Ah Kim
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Immune Defense ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Wide Range ◽  
Adult Onset Still's Disease

Neutrophils are innate immune phagocytes that play a key role in immune defense against invading pathogens. The main offensive mechanisms of neutrophils are the phagocytosis of pathogens, release of granules, and production of cytokines. The formation of neutrophil extracellular traps (NETs) has been described as a novel defense mechanism in the literature. NETs are a network of fibers assembled from chromatin deoxyribonucleic acid, histones, and neutrophil granule proteins that have the ability to kill pathogens, while they can also cause toxic effects in hosts. Activated neutrophils with NET formation stimulate autoimmune responses related to a wide range of inflammatory autoimmune diseases by exposing autoantigens in susceptible individuals. The association between increased NET formation and autoimmunity was first reported in antineutrophil cytoplasmic antibody-related vasculitis, and the role of NETs in various diseases, including systemic lupus erythematosus, rheumatoid arthritis, and psoriasis, has since been elucidated in research. Herein, we discuss the mechanistic role of neutrophils, including NETs, in the pathogenesis of systemic juvenile idiopathic arthritis (SJIA) and adult-onset Still’s disease (AOSD), and provide their clinical values as biomarkers for monitoring and prognosis.

scholarly journals Interluekin-6 inhibitors for the treatment of adult-onset Still’s disease

2021 ◽  
Author(s):  
Yuko Kaneko
Keyword(s):  
Proinflammatory Cytokines ◽  
Cytotoxic T Cells ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Systemic Inflammatory Disease ◽  
Adult Onset Still's Disease ◽  
Multifunctional Cytokine

ABSTRACT Adult-onset Still’s disease is a systemic inflammatory disease characterized by high spiking fever, arthritis, evanescent skin rash, leukocytosis, and hyperferritinemia. The pathogenesis of adult-onset Still’s disease has not been fully understood yet; however, multiple proinflammatory cytokines, such as IL-1β and IL-6, play important roles in the development of adult-onset Still’s disease. IL-6 is a multifunctional cytokine that accelerates the differentiation of macrophages and cytotoxic T-cells and chemotaxis of neutrophils and macrophages. Serum concentrations of IL-6 well correlate with disease activity of adult-onset Still’s disease, and blockade of IL-6 has been proven to be effective in active adult-onset Still’s disease. This review will focus on the recent understanding of the role of proinflammatory cytokines of adult-onset Still’s disease and the efficacy of IL-6 inhibitors for the treatment of adult-onset Still’s disease.

scholarly journals Adult-onset Still's disease and the role of dermatological manifestations: A case report and literature review

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Andrei Vâță ◽  
Ionela Vlăduțu ◽  
Carmen Manciuc ◽  
Cristina Lăcătusu ◽  
Alexandra Burlui ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Adult Onset Still's Disease

Elevated circulating pro-inflammatory low-density granulocytes in adult-onset Still’s disease

Rheumatology ◽  
2020 ◽  
Vol 60 (1) ◽  
pp. 297-303 ◽  
Author(s):  
Yudong Liu ◽  
Changsheng Xia ◽  
Jiali Chen ◽  
Chunhong Fan ◽  
Jing He
Keyword(s):  
Mononuclear Cells ◽  
Nonparametric Test ◽  
Adult Onset Still’S Disease ◽  
Low Density ◽  
Adult Onset ◽  
Still’S Disease ◽  
Peripheral Blood Mononuclear ◽  
Still's Disease ◽  
Adult Onset Still's Disease

Abstract Objectives Neutrophilia is a hallmark of adult-onset Still’s disease (AOSD). This study aimed to investigate the role of a distinct subset of granulocytes, the low-density granulocytes (LDGs) in the pathogenesis of AOSD. Methods A total of 56 patients with AOSD were included in the study. LDGs were quantified by flow cytometry. Correlations between LDGs with disease activity and laboratory parameters were determined by Spearman’s nonparametric test. The cellular sources of the pro-inflammatory cytokines in AOSD were determined by intracellular staining. Results Active AOSD patients displayed significantly higher levels of LDGs compared with inactive AOSD patients and healthy controls (HCs) (P<0.001). Circulating LDGs were significantly correlated with CRP, ESR and the modified Pouchot score in patients with AOSD (P<0.01). The levels of LDGs were significantly decreased after the active AOSD patients achieved disease remission (P=0.0391). CD14+ monocytes constituted over 90% IL-1β+ peripheral blood mononuclear cells (PBMCs) and over 80% TNF-α+ PBMCs in both active AOSD patients and HCs, respectively. In active AOSD, CD14+ monocytes accounted for 24.6% to 75.0% of IL-6+ PBMCs, while LDGs comprised 22.8% to 72.2% of IL-6+ PBMCs. In contrast, over 90% IL-6+ PBMCs were CD14+ monocytes in HCs. A significant correlation was identified between the levels of LDGs and serum IL-6 levels in AOSD (P<0.0001). Conclusion Active AOSD is associated with elevated levels of a pro-inflammatory subset of neutrophils, the LDGs that produce IL-6. Our data highlight an unappreciated role of LDGs in the aberrant innate immune responses in AOSD.

scholarly journals Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease

Rheumatology ◽  
2010 ◽  
Vol 49 (12) ◽  
pp. 2305-2312 ◽  
Author(s):  
D.-Y. Chen ◽  
Y.-M. Chen ◽  
J.-L. Lan ◽  
C.-C. Lin ◽  
H.-H. Chen ◽  
...  
Keyword(s):  
Th17 Cells ◽  
Potential Role ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Adult Onset Still's Disease
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