The Importance of Heart Rate Variability in Predicting Cardiac Autonomic Dysfunction in Patients with Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Dilek İşcan ◽  
Muhammet Buğra Karaaslan ◽  
Onur Sinan Deveci ◽  
Rabia Akıllı Eker ◽  
Filiz Koç
Keyword(s):  
Heart Rate ◽  
Amyotrophic Lateral Sclerosis ◽  
Heart Rate Variability ◽  
Autonomic Dysfunction ◽  
Cardiac Autonomic Dysfunction ◽  
Lateral Sclerosis

Decreased heart rate variability in amyotrophic lateral sclerosis

1995 ◽  
Vol 18 (11) ◽  
pp. 1225-1231 ◽  
Author(s):  
Fabrizio Pisano ◽  
Giacinta Miscio ◽  
Giorgio Mazzuero ◽  
Paola Lanfranchi ◽  
Roberto Colombo ◽  
...  
Keyword(s):  
Heart Rate ◽  
Amyotrophic Lateral Sclerosis ◽  
Heart Rate Variability ◽  
Lateral Sclerosis

scholarly journals Chemical Sympathectomy Restores Baroreceptor-Heart Rate Reflex and Heart Rate Variability in Rats With Chronic Nitric Oxide Deficiency

2015 ◽  
pp. 459-466 ◽  
Author(s):  
M. CHASWAL ◽  
S. DAS ◽  
J. PRASAD ◽  
A. KATYAL ◽  
M. FAHIM
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Frequency Domain ◽  
Autonomic Dysfunction ◽  
Sympathetic Innervation ◽  
Chemical Sympathectomy ◽  
Principal Mechanism ◽  
Cardiac Autonomic Dysfunction

Nitric oxide (NO) plays a crucial role not only in regulation of blood pressure but also in maintenance of cardiac autonomic tone and its deficiency induced hypertension is accompanied by cardiac autonomic dysfunction. However, underlying mechanisms are not clearly defined. We hypothesized that sympathetic activation mediates hemodynamic and cardiac autonomic changes consequent to deficient NO synthesis. We used chemical sympathectomy by 6-hydroxydopamine to examine the influence of sympathetic innervation on baroreflex sensitivity (BRS) and heart rate variability (HRV) of chronic NG-nitro-L-arginine methyl ester (L-NAME) treated adult Wistar rats. BRS was determined from heart rate responses to changes in systolic arterial pressure achieved by intravenous administration of phenylephrine and sodium nitroprusside. Time and frequency domain measures of HRV were calculated from 5-min electrocardiogram recordings. Chronic L-NAME administration (50 mg/kg per day for 7 days orally through gavage) in control rats produced significant elevation of blood pressure, tachycardia, attenuation of BRS for bradycardia and tachycardia reflex and fall in time as well as frequency domain parameters of HRV. Sympathectomy completely abolished the pressor as well as tachycardic effect of chronic L-NAME. In addition, BRS and HRV improved after removal of sympathetic influence in chronic L-NAME treated rats. These results support the concept that an exaggerated sympathetic activity is the principal mechanism of chronic L NAME hypertension and associated autonomic dysfunction.

scholarly journals Decreased Heart Rate Variability in Individuals With Amyotrophic Lateral Sclerosis

2019 ◽  
Vol 64 (9) ◽  
pp. 1088-1095
Author(s):  
Renata M M Pimentel ◽  
Hugo Macedo ◽  
Vítor E Valenti ◽  
Fernando O Rocha ◽  
Luiz Carlos Abreu ◽  
...  
Keyword(s):  
Heart Rate ◽  
Amyotrophic Lateral Sclerosis ◽  
Heart Rate Variability ◽  
Lateral Sclerosis

Decreased heart rate variability in amyotrophic lateral sclerosis

1993 ◽  
Vol 43 ◽  
pp. 90
Author(s):  
P. Lanfranchi ◽  
G. Mazzuero ◽  
G. Misco ◽  
F. Pisano ◽  
R. Colombo
Keyword(s):  
Heart Rate ◽  
Amyotrophic Lateral Sclerosis ◽  
Heart Rate Variability ◽  
Lateral Sclerosis
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