Clinical significance of large unstained cell count in estimating the current activity of ANCA‐associated vasculitis

2021 ◽  
Author(s):  
Lucy Eunju Lee ◽  
Jung Yoon Pyo ◽  
Sung Soo Ahn ◽  
Jason Jungsik Song ◽  
Yong‐Beom Park ◽  
...  
Keyword(s):  
Cell Count ◽  
Clinical Significance ◽  
Anca Associated Vasculitis ◽  
Current Activity

Clinical Significance of Cytocentrifuge Preparation Analysis of Low-Cell-Count Cerebrospinal Fluid Specimens.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3872-3872
Author(s):  
Guylaine Lajeunesse-Viens ◽  
Bernadette Dufault ◽  
Xiaoduan Weng ◽  
Bernard Lemieux ◽  
Marie Florescu
Keyword(s):  
Central Nervous System ◽  
Flow Cytometry ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Cell Count ◽  
Clinical Significance ◽  
Clinical History ◽  
Clinical Impact ◽  
Cns Involvement ◽  
Central Nervous System Infiltration

Abstract Introduction: The usefulness of performing a cytocentrifuge preparation (CCP) analysis on cerebrospinal fluid (CSF) containing less than 5 cells has never been studied. To determine if the CCP analysis has a clinical impact on central nervous system (CNS) management of patients with CSF samples containing less than five cells, we correlated the result of CCP to cytomorphology and flow cytometry. Methods: From November 20th 2005 to July 18th 2007, CCP analysis were performed on 105 CSF consecutive samples containing less than 5 cells from patients with various cancers. For each of these samples, a research via computerized data was conducted to obtain cytomorphology and flow cytometry results. If results were positive or inconclusive, the clinical history and treatment were reviewed. Results: All 105 samples had negative CCP results. Of the 105 samples, 74 (70,5%) had available cytomorphologies, with 5 (6,8%) being positive, confirming central nervous system infiltration. All 5 patients received treatment for their CNS involvement. The sensitivity of cytomorphology was 83,3%(5/6) and its specificity 100% (68/68).Of the 105 samples, 23 (21,9%) had available flow cytometries: 4 of the 23 (17,4%) cytometries were positive, 2 correlated by positive cytomorphology and treated. 2 had negative cytomorphology with one patient receiving treatment. The sensitivity of cytometry was 75% (3/4) and the specificity 94,7% (19/20). Conclusion: We found no advantage to performing CCP analysis on CSF samples of less than 5 cells. However, this suggests that performing both cytomorphology and flow cytometry allows a better detection and management of CNS infiltration.

scholarly journals Clinical significance and influencing factors of fibrinogen in ANCA-associated vasculitis

Medicine ◽  
2020 ◽  
Vol 99 (39) ◽  
pp. e22424
Author(s):  
Naidan Zhang ◽  
Jiaxiang Sun ◽  
Chaixia Ji ◽  
Yusha Zhou ◽  
Xiao Bao ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Influencing Factors ◽  
Anca Associated Vasculitis

Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma

2000 ◽  
Vol 15 (11) ◽  
pp. 1333-1338 ◽  
Author(s):  
Koji Uno ◽  
Takeshi Azuma ◽  
Masatsugu Nakajima ◽  
Kenjiro Yasuda ◽  
Takanobu Hayakumo ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Clinical Significance ◽  
Pancreatic Juice ◽  
Ductal Adenocarcinoma ◽  
Cathepsin E
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