Positive effects of selenium supplementation in women with newly diagnosed Hashimoto's thyroiditis in an area with low selenium status

2021 ◽  
Author(s):  
Jadwiga Kryczyk‐Kozioł ◽  
Paweł Zagrodzki ◽  
Ewelina Prochownik ◽  
Anna Błażewska‐Gruszczyk ◽  
Marian Słowiaczek ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Selenium Supplementation ◽  
Hashimoto's Thyroiditis ◽  
Selenium Status ◽  
Newly Diagnosed ◽  
Positive Effects ◽  
Low Selenium

scholarly journals Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis

2016 ◽  
Vol 50 (2) ◽  
pp. 55-61 ◽  
Author(s):  
Hakki Yilmaz ◽  
M. Cakmak ◽  
B. Ceydilek ◽  
C. Demir ◽  
A. Aktas
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Critical Role ◽  
Thyroid Stimulating Hormone ◽  
Hashimoto's Thyroiditis ◽  
Interleukin 12 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Thyroid Peroxidase ◽  
Newly Diagnosed ◽  
Group 2 ◽  
Group 1

AbstractObjective. Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function of Tregs. Growing evidence revealed that upregulation of IL-35 expression may play a critical role in the prevention of autoimmune diseases in various experimental autoimmunity models and vice versa. Hashimoto’s thyroiditis (HT) is considered to be a Treg cell-related autoimmune disease with loss of self-tolerance. Methods. One hundred-twenty eight subjects, newly diagnosed hypothyroid HT patients [56 overt (Group 1), 72 subclinical hypothyroid (Group 2)] and 38 healthy controls (Group 3) were enrolled in the study. The levels of serum IL-35 were determined by enzyme-linked immunosorbent assay (ELISA). Results. Serum IL-35 levels were lower in the HT group when compared with subclinical HT group [304.5 (834.6) pg/ml vs. 636.1 (1542.0) pg/ml, p=0.004] and control cases [304.5 (834.6) pg/ml vs. 1064.7 (2526.8) pg/ml, p<0.001]. Serum IL-35 levels were inversely associated with thyroid stimulating hormone (TSH; rs=-0.396, p<0.001) and anti-thyroid peroxidase antibodies (TPOAb; rs=-0.571, p<0.001) in whole group. Serum IL-35 were negatively associated with TSH (rs=-0.264, p=0.003) and TPOAb (rs=-0.735, p<0.001) in patients with Hashimoto’s thyroiditis (Group 1 + Group 2). Conclusion. The results suggest that IL-35 may play a role in the pathogenesis of HT.

scholarly journals Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review

2013 ◽  
Vol 3 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Esther J. van Zuuren ◽  
Amira Y. Albusta ◽  
Zbys Fedorowicz ◽  
Ben Carter ◽  
Hanno Pijl
Keyword(s):  
Systematic Review ◽  
Hashimoto’S Thyroiditis ◽  
Selenium Supplementation ◽  
Hashimoto's Thyroiditis ◽  
Cochrane Systematic Review

scholarly journals Thyroid Autoimmunity: Exploring the Role of Th17-associated Cytokines and Pathomorphological Mechanisms Involved in the Pathogenesis of Hashimoto’s Thyroiditis and Graves’ Disease. Summary of the Doctoral Thesis

2021 ◽  
Author(s):  
◽  
Tatjana Zaķe ◽  
Keyword(s):  
Immune Response ◽  
Plasma Levels ◽  
Th17 Cells ◽  
Thyroid Autoimmunity ◽  
Selenium Supplementation ◽  
Graves Disease ◽  
Selenium Status ◽  
Newly Diagnosed ◽  
Thyroid Follicle

The prevalence and incidence of autoimmune thyroid diseases (AITD), presenting as Graves’ disease (GD) or Hashimoto’s thyroiditis (HT), has increased significantly in recent decades. It is crucial to identify immunological and pathomorphological factors involved in thyroid autoimmunity. Classically, HT has long been considered as a T helper (Th)1-mediated disease, while a Th2-driven autoimmune response is dominant for GD. Recently, Th17 cells have been established to play a role in the pathogenesis of AITD, however, their contribution to the initiation and progression of AITD remains unclear. Furthermore, selenium deficiency can impair the differentiation of Th cells, leading to dysfunction of cellular and humoral response. The aim of this thesis was to explore the role of Th17 cells in the pathogenesis of HT and GD by the use of different morphology methods and xMAP technology, and correlating these data with the selenium status. The initial study included 29 adult patients with AITD who underwent thyroidectomy, whereas subsequent clinical research project involved 52 patients with newly diagnosed, treatment-naïve AITD, as well as 26 healthy subjects served as controls. The plasma levels of Th17-associated cytokines – interleukin (IL)-17, IL-22, IL-23, IL-6, and IL-10 and the distribution and levels of immunoexpression IL-17, IL-23, and IL-1β within thyroid tissue were measured to characterize Th17 immune response in AITD. The integrity of the thyroid follicle by studying immunoexpression of cellular tight junctions – zonula occludens-1 and claudin-1 proteins, coupled to IL-17 and CD68, was explored. In addition, the selenium status was assessed. No significant differences in the plasma levels of Th17-associated cytokines were found among the patients with AITD and control subjects. However, the expression level of IL-17 in the thyrocytes was significantly higher in the HT and GD patients than in controls, simultaneously correlating with IL-23 and IL-1β immunopositivity in the HT group. Plasma Th17-associated cytokines’ levels were positively correlated with the severity of hyperthyroidism, independent of autoantibody levels, thus suggesting their possible role in GD pathogenesis. The changes in molecules of thyrocyte junctional complexes highlighting impairment of the integrity of thyroid follicle in HT were observed, but no significant association with IL-17 was found. Although no difference in selenium levels was observed between the AITD patients and controls, the results of the given research suggest the selenium status of the Latvian patients with newly diagnosed GD or HT is at a suboptimal level. Plasma selenium levels were negatively correlated with anti-thyroperoxidase (TPO) autoantibody titres in the HT patients, thus supporting the immunomodulatory role of selenium in AITD. Moreover, HT patients with higher anti-TPO autoantibody levels had lower levels of selenium, suggesting that these patients might benefit from selenium supplementation. Essential information deepening our knowledge about thyroid autoimmunity was obtained conducting this research, however, further experimental studies exploring the role and regulatory effects of Th17-related cytokines in the pathogenesis of AITD are required. More data from clinical studies are needed for a better understanding of the relationship between selenium supplementation and immune response.

Selenium supplementation of grazing sheep. I. Effects of selenium drenching and other factors on plasma and erythrocyte glutathione peroxidase activities and blood selenium concentrations of lambs and ewes

1980 ◽  
Vol 31 (5) ◽  
pp. 991 ◽  
Author(s):  
DW Peter ◽  
PG Board ◽  
MJ Palmer
Keyword(s):  
Glutathione Peroxidase ◽  
New England ◽  
Whole Blood ◽  
Selenium Supplementation ◽  
Selenium Status ◽  
Blood Concentrations ◽  
South Wales ◽  
Grazing Area ◽  
Grazing Sheep ◽  
Low Selenium

Lambs or ewes grazing pastures in the low selenium region of New England in New South Wales were used to study the effects of selenium supplementation on blood and plasma levels of selenium and glutathione peroxidase (GSH-px), and to assess the possibility of using GSH-px activity as an indicator of selenium availability or selenium status in grazing sheep. When lambs were drenched with selenium at 14 days of age there were large and rapid increases in the initially low levels of plasma and erythrocyte GSH-px. The increase in plasma GSH-px was transitory, and a second selenium drench administered to half the treated lambs at 42 days did not evoke any further increase. Erythrocyte GSH-px activities of treated lambs remained elevated for a longer period than plasma GSH-px, and the second selenium drench extended the period of elevation. Alterations in plasma GSH-px of adult ewes drenched with selenium were similar to those observed in the lambs, but erythrocyte GSH-px activities increased much more slowly. The changes in plasma and erythrocyte GSH-px were accompanied by significant alterations in plasma and whole blood concentrations of selenium. Increases in whole blood selenium, because of the plasma component, were much more rapid than those in erythrocyte GSH-px. Transfer of ewes to a new grazing area with a different soil and pasture type led to similar changes in plasma and erythrocyte GSH-px to those produced by selenium drenching. Small increases with time were also observed in the erythrocyte GSH-px activity of untreated ewes grazing the same pasture continuously. These changes were presumably the result of changes in the selenium content and/or availability in the pasture. It was concluded that regular estimations of erythrocyte or whole blood GSH-px activities could be used as an indication of selenium availability and the selenium status of grazing sheep. Changes in pasture and/or grazing area, and the fact that erythrocyte GSH-px activity of adult animals does not immediately attain a new equilibrium value when selenium intake alters must however be taken into account.

scholarly journals A Higher Frequency of Circulating IL-22+CD4+ T Cells in Chinese Patients with Newly Diagnosed Hashimoto’s Thyroiditis

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e84545 ◽  
Author(s):  
Hui Guo ◽  
Di Peng ◽  
Xi-Ge Yang ◽  
Ye Wang ◽  
Bing-Chuan Xu ◽  
...  
Keyword(s):  
T Cells ◽  
Hashimoto’S Thyroiditis ◽  
Cd4 T Cells ◽  
Chinese Patients ◽  
Hashimoto's Thyroiditis ◽  
Newly Diagnosed

Selenium Supplementation in the Treatment of Hashimoto's Thyroiditis: A Systematic Review and a Meta-analysis

Thyroid ◽  
2010 ◽  
Vol 20 (10) ◽  
pp. 1163-1173 ◽  
Author(s):  
Konstantinos A. Toulis ◽  
Athanasios D. Anastasilakis ◽  
Thrasivoulos G. Tzellos ◽  
Dimitrios G. Goulis ◽  
Dimitrios Kouvelas
Keyword(s):  
Systematic Review ◽  
Hashimoto’S Thyroiditis ◽  
Meta Analysis ◽  
Selenium Supplementation ◽  
Hashimoto's Thyroiditis

Serum Levels of Soluble Receptor for Advanced Glycation End Products Are Reduced in Euthyroid Children with Newly Diagnosed Hashimoto’s Thyroiditis: A Pilot Study

2021 ◽  
pp. 1-7
Author(s):  
Tommaso Aversa ◽  
Rosaria Maddalena Ruggeri ◽  
Domenico Corica ◽  
Maria Teresa Cristani ◽  
Giorgia Pepe ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Hashimoto’S Thyroiditis ◽  
Pediatric Patients ◽  
Serum Levels ◽  
Hashimoto's Thyroiditis ◽  
Soluble Receptor ◽  
Newly Diagnosed ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

<b><i>Objective:</i></b> No data are available on advanced glycation end products (AGEs) and their soluble receptor (sRAGE) in pediatric patients with Hashimoto’s thyroiditis (HT). The present study was aimed to simultaneously evaluate serum levels of sRAGE, AGEs, and advanced oxidation protein products (AOPPs) and investigate the relationships between these oxidative stress markers and clinical and biochemical parameters of thyroid function in euthyroid children with HT. <b><i>Design:</i></b> This is a case-control study carried out in a single university hospital center. <b><i>Methods:</i></b> We enrolled 19 newly diagnosed euthyroid HT pediatric patients (3 M, 16 F; median age 12.44 years, range 6.54–15.81 years) and 16 age-, sex-, and BMI-matched healthy controls (5 M, 11 F; median age 12.83 years, range 5.68–15.07 years). None was on levothyroxine treatment. The exclusion criteria were autoimmune, inflammatory, and infection comorbidities. Patients did not differ significantly from controls with regard to lipid or for anthropometric parameters. <b><i>Results:</i></b> sRAGE levels were significantly lower in HT patients (median 414.30 pg/mL, range 307.30–850.30 pg/mL) than in controls (561.30, 273.20–1121.60 pg/mL; <i>p</i> = 0.034). No differences emerged between patients and controls with regard to serum AGEs (124.25 AU/g prot, 71.98–186.72 vs. 133.90, 94.06–200.78 AU/g prot, <i>p</i> = 0.707) and AOPPs (1.13 nmol/mL, 0.62–1.83 vs. 1.17, 0.76–1.42 nmol/mL, <i>p</i> = 0.545). <b><i>Conclusions:</i></b> sRAGE levels were decreased in euthyroid children/adolescents at the onset of HT, suggesting that autoimmunity per se seems to play an important role in such a reduction of sRAGE, irrespective of any functional alteration. Children and adolescents suffering from HT may exhibit increased susceptibility to oxidative damage, even when in euthyroid status.

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