Association of novel Stop Gained Leukemia Inhibitory Factor Receptor Gene (rs121912501)Variant, Leukemia Inhibitory Factor and Ovarian Steroids with Unexplained Infertility among Pakistani women

2021 ◽  
Author(s):  
Rabiya Ali ◽  
Mehir un Nisa Iqbal ◽  
Rehana Rehman ◽  
Taseer A Khan
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Receptor Gene ◽  
Unexplained Infertility ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor ◽  
Ovarian Steroids ◽  
Pakistani Women

scholarly journals Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

Development ◽  
1995 ◽  
Vol 121 (5) ◽  
pp. 1283-1299 ◽  
Author(s):  
C.B. Ware ◽  
M.C. Horowitz ◽  
B.R. Renshaw ◽  
J.S. Hunt ◽  
D. Liggitt ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Perinatal Death ◽  
Receptor Gene ◽  
Primordial Germ Cell ◽  
Late Gestation ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor ◽  
Targeted Disruption ◽  
Metabolic Defects ◽  
Cell Compartments

The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.

The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1

2015 ◽  
Vol 117 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Abeer A. Qadi ◽  
Phillippa C. Taberlay ◽  
Jessica L. Phillips ◽  
Arabella Young ◽  
Alison C. West ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Receptor Gene ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor ◽  
Direct Target

The role of the leukemia inhibitory factor receptor in embryo implantation and placentation

Placenta ◽  
2021 ◽  
Vol 114 ◽  
pp. 139
Author(s):  
Jumpei Terakawa ◽  
Kazuhiro Matsuo ◽  
Takafumi Namiki ◽  
Kana Ohtomo ◽  
Atsuko Kageyama ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Embryo Implantation ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor
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