Association of gonadal hormones and sex hormone binding globulin with risk of diabetes: a cohort study in middle‐aged and elderly males

2021 ◽  
Author(s):  
Na Li ◽  
Chulin Huang ◽  
Biyun Lan ◽  
Diaozhu Lin ◽  
Chengzhi Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gonadal Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Middle Aged ◽  
Elderly Males

scholarly journals High sex hormone-binding globulin concentration is a risk factor for high fibrosis-4 index in middle-aged Japanese men

2019 ◽  
Vol 66 (7) ◽  
pp. 637-645 ◽  
Author(s):  
Yuya Fujihara ◽  
Nobuya Hamanoue ◽  
Hiromi Yano ◽  
Makito Tanabe ◽  
Yuko Akehi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Middle Aged ◽  
Japanese Men

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

2017 ◽  
Vol 50 (02) ◽  
pp. 138-144 ◽  
Author(s):  
Khalid Siddiqui ◽  
Khalid Al-Rubeaan ◽  
Shaik Nawaz ◽  
Khaled Aburisheh ◽  
Anas Alaabdin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
International Diabetes Federation ◽  
Free Testosterone ◽  
Gonadal Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

AbstractSex hormone binding globulin (SHBG) is demonstrated to be decreased in subjects with metabolic syndrome (MetS). The aim of the present study was to investigate the association of SHBG in relation to MetS components among men with type 2 diabetes (T2D). This cross-sectional study was carried out among 429 Saudi T2D male patients aged >30 years. Metabolic syndrome was defined using International Diabetes Federation (IDF) criteria. Fasting blood glucose (FBG), HbA1c, albumin, and lipid parameter were measured. Gonadal hormones, namely total testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and SHBG were determined using ELISA. The SHBG levels of the MetS group was significantly lower than non-MetS group 47.25±31.03 nmol/l vs. 56.55±37.84 nmol/l; p=0.013. As the MetS score increases, SHBG and HDL levels decrease while weight, BMI, waist circumference, SBP, DBP, FBG, HbA1c, TC, and TG levels increase. SHBG correlated with age, BMI, TG, HDL, TT, free testosterone, and bio-available testosterone. This is the first study that provides detailed analyses of SHBG with MetS components in male diabetic subjects. The mean serum SHBG levels gradually declined with the addition of MetS components in T2D men. TT, free testosterone, and bio-available testosterone remained independently associated with SHBG by multivariable regression analysis.

scholarly journals Associations of Total Testosterone and Sex Hormone-Binding Globulin Levels With Insulin Sensitivity in Middle-Aged Finnish Men

Diabetes Care ◽  
2007 ◽  
Vol 30 (4) ◽  
pp. e13-e13 ◽  
Author(s):  
U. M. Rajala ◽  
S. M. Keinanen-Kiukaanniemi ◽  
P. K. Hirsso ◽  
J. J. Jokelainen ◽  
M. A. Laakso ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Middle Aged

Androgens, Estrogens, and Sex Hormone-Binding Globulin in Middle-Aged Men*

1990 ◽  
Vol 71 (6) ◽  
pp. 1442-1446 ◽  
Author(s):  
C. LONGCOPE ◽  
S. R. W. GOLDFIELD ◽  
D. J. BRAMBILLA ◽  
J. MCKINLAY
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Middle Aged

scholarly journals Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men

2020 ◽  
Vol 6 (4) ◽  
pp. 425-433
Author(s):  
Yuya Fujihara ◽  
Nobuya Hamanoue ◽  
Yuko Akehi ◽  
Ryoko Motonaga ◽  
Tomoko Tanaka ◽  
...  
Keyword(s):  
Risk Factor ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Middle Aged ◽  
Japanese Men

scholarly journals Testosterone and Sex Hormone-Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men

Diabetes Care ◽  
2004 ◽  
Vol 27 (5) ◽  
pp. 1036-1041 ◽  
Author(s):  
D. E. Laaksonen ◽  
L. Niskanen ◽  
K. Punnonen ◽  
K. Nyyssonen ◽  
T.-P. Tuomainen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Middle Aged ◽  
The Metabolic Syndrome
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