Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease diagnosed by transient elastography and liver biopsy

2021 ◽  
Author(s):  
I. Mikolasevic ◽  
B. Delija ◽  
A. Mijic ◽  
T. Stevanovic ◽  
N. Skenderevic ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Biopsy ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Transient Elastography ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Nonalcoholic Fatty Liver ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal

Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease

2020 ◽  
Vol 32 (5) ◽  
pp. 601-608 ◽  
Author(s):  
Karn Wijarnpreecha ◽  
Susan Lou ◽  
Kanramon Watthanasuntorn ◽  
Paul T. Kroner ◽  
Wisit Cheungpasitporn ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Nonalcoholic Fatty Liver ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal

scholarly journals Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260479
Author(s):  
Linghan Kuang ◽  
Wei Zhou ◽  
Yongmei Jiang
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Nonalcoholic Fatty Liver ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal

It has been suggested that small intestinal bacterial overgrowth (SIBO) could cause nonalcoholic fatty liver disease (NAFLD), but this association was not examined in children by meta-analysis. This meta-analysis aimed to determine the association between SIBO and NAFLD in children. The electronic databases PubMed, Embase, and Cochrane Library were searched for studies published before April 22, 2021. The outcome was the association between SIBO and NAFLD. Three studies and 205 children were included. All three studies reported the association between SIBO and NAFLD. Children with SIBO were more likely to have NAFLD (odds ratio = 5.27, 95% confidence interval (CI): 1.66–16.68, P<0.001; I2 = 63.5%, Pheterogeneity = 0.065). When directly pooling the reported relative risks (RR) from two studies, children with NAFLD had an over 2-fold increased relative risk of developing SIBO (RR = 2.17, 05%CI: 1.66–2.82, P<0.001; I2 = 0.0%, Pheterogeneity = 0.837). This meta-analysis reports a possible association between SIBO and NAFLD in children.

Small Intestinal Bacterial Overgrowth and Orocecal Transit Time in Patients of Nonalcoholic Fatty Liver Disease

2020 ◽  
Author(s):  
Haitao Shi ◽  
Lijuan Mao ◽  
Lianli Wang ◽  
Xiaojing Quan ◽  
Xiaoyu Xu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver Disease ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Healthy Controls ◽  
Orocecal Transit Time ◽  
Nonalcoholic Fatty Liver ◽  
Intestinal Bacterial Overgrowth ◽  
Orocecal Transit ◽  
Small Intestinal

Abstract Background: To explore the frequency of small intestinal bacterial overgrowth (SIBO) and orocecal transit time (OCTT) in patients with nonalcoholic fatty liver disease (NAFLD). Methods: 103 patients with NAFLD and 49 healthy controls were enrolled. Clinical indicators such as body mass index (BMI), liver function, blood lipids, HOMA-IR, serum endotoxin of NAFLD patients were collected and examined. Fibro Touch was used to detect the (controlled attenuation parameter) CAP and liver stiffness measurement (LSM). SIBO and OCTT were measured by lactulose hydrogen breath test. Results: The incidence of SIBO in NAFLD patients (58.3%) was significantly higher than that in healthy controls (26.5%). The level of serum endotoxin in NAFLD patients was higher than that in healthy controls. The levels of CAP, LSM, serum endotoxin, ALT, AST and HOMA-IR in SBIO-positive NAFLD patients were higher than those in SIBO-negative patients. There was no significant difference in GGT, TG, LDL and BMI between the two groups. OCTT in NAFLD patients was longer than that in healthy controls. It was also observed that OCTT in SIBO-positive NAFLD patients was significantly delayed compared with SIBO-negative NAFLD patients. Conclusions: Patients with NAFLD exhibit the increased incidence rate of SIBO and prolonged OCTT; SIBO in NAFLD patients is a contributing factor to the elevated transaminase, hepatic steatosis, progression of liver fibrosis and prolonged OCTT.

scholarly journals Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth

2018 ◽  
Vol 56 (2) ◽  
pp. 85-89
Author(s):  
Rahmatollah Rafiei ◽  
Mahboobeh Bemanian ◽  
Fereshteh Rafiei ◽  
Mahmood Bahrami ◽  
Lotfollah Fooladi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Alcoholic Fatty Liver ◽  
Intestinal Bacterial Overgrowth ◽  
Significant Difference ◽  
Small Intestinal ◽  
Alcoholic Fatty Liver Disease

Abstract Introduction. It seems that there is a relationship between small intestinal bacterial overgrowth (SIBO) and non-alcoholic fatty liver disease (NAFLD). The main objective of this study was to evaluate the prevalence of SIBO among NAFLD patients. Methods. In this descriptive-analytical cross-sectional study, 98 eligible NAFLD patients were evaluated for SIBO using hydrogen breath test (HBT). They were divided into SIBO-positive and SIBO-negative groups. Demographic, clinical, and laboratory data were obtained. Results. Based on the HBT, 38 patients (39%) had bacteria overgrowth. There were no significant differences between SIBO-positive and SIBO-negative regarding demographic data and BMI classification (P > 0.05). Biochemical variables, the results of abdominal ultrasound, and liver elastography did not show any significant difference between SIBO-positive and SIBO-negative patients (P > 0.05). Patients with SIBO were found to have higher rates of bloating, while abdominal pain was more prevalent in SIBO-negative patients (P < 0.001). Conclusions. SIBO is prevalent in NAFLD and associated with bloating in these patients. Further studies are necessary to elucidate if therapeutic manipulation of gut microbiota reduces the risk of NAFLD, fibrosis, and liver cirrhosis.

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