Alpha‐lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta‐analysis of randomised placebo‐controlled clinical trials

2020 ◽  
Vol 74 (6) ◽  
Author(s):  
Mahdi Vajdi ◽  
Mahdieh Abbasalizad Farhangi
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Lipoic Acid ◽  
Dose Response ◽  
Meta Analysis ◽  
Alpha Lipoic Acid ◽  
Controlled Clinical Trials ◽  
Acid Supplementation

Effect of alpha-lipoic acid supplementation on lipid profile: A systematic review and meta-analysis of controlled clinical trials

Nutrition ◽  
2019 ◽  
Vol 59 ◽  
pp. 121-130 ◽  
Author(s):  
Seyed Mohammad Mousavi ◽  
Sakineh Shab-Bidar ◽  
Hamed Kord-Varkaneh ◽  
Masoud Khorshidi ◽  
Kurosh Djafarian
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Lipid Profile ◽  
Lipoic Acid ◽  
Meta Analysis ◽  
Alpha Lipoic Acid ◽  
Controlled Clinical Trials ◽  
Acid Supplementation

The effect of Alpha‐lipoic acid supplementation on endothelial function: A systematic review and meta‐analysis

2020 ◽  
Author(s):  
Yahya Jalilpiran ◽  
Maryam Hajishafiee ◽  
Masoud Khorshidi ◽  
Hamid Rezvani ◽  
Mohsen Mohammadi‐Sartang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Endothelial Function ◽  
Lipoic Acid ◽  
Meta Analysis ◽  
Alpha Lipoic Acid ◽  
Acid Supplementation

An updated systematic review and dose-response meta-analysis of the randomized controlled trials on the effects of Alpha-Lipoic acid supplementation on inflammatory biomarkers

2021 ◽  
pp. 1-14
Author(s):  
Mahdi Vajdi ◽  
Mahsa Mahmoudi-Nezhad ◽  
Mahdieh Abbasalizad Farhangi
Keyword(s):  
Systematic Review ◽  
Lipoic Acid ◽  
Dose Response ◽  
Subgroup Analysis ◽  
Inflammatory Markers ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Alpha Lipoic Acid ◽  
Randomized Controlled ◽  
Tnf Α

Abstract. Data about the effects of alpha-lipoic acid (ALA) supplementation on inflammatory markers are inconsistent. This systematic review and dose-response meta-analysis of randomized controlled trials was performed to summarize the effects of ALA supplementation on inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in adults. A comprehensive literature search was conducted in the electronic databases of PubMed, Web of Science, ProQuest, Embase, and SCOPUS from inception to February 2020. Among all of the eligible studies, 20 articles were selected. The weighted mean differences (WMD) and 95% confidence intervals (CI) were calculated to evaluate the pooled effect size. Between-study heterogeneity was evaluated using Cochran’s Q test and I2. Subgroup analysis was done to evaluate the potential sources of heterogeneity. The dose-response relationship was evaluated using fractional polynomial modeling. Twenty eligible studies with a total sample size of 947 participants were included in the current meta-analysis. The findings of the meta-analysis showed that ALA supplementation significantly reduced CRP (WMD: −0.69 mg/L, 95% CI: −1.13, −0.26, P=0.002), IL-6 (WMD: −1.83 pg/ml, 95% CI: −2.90, −0.76, P=0.001), and TNF-α concentrations (WMD: −0.45 pg/ml, 95% CI: −0.85, −0.04, P=0.032). No evidence of departure from linearity was observed between dose and duration of the ALA supplementation on serum CRP, IL-6 and TNF-α concentration. In subgroup analysis, ALA dosage, baseline concentrations of the parameter, sample size, and gender were considered as possible sources of heterogeneity. In summary, ALA supplementation improves inflammatory markers without any evidence of non-linear association to dose or duration of the trial.

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