Dietary acid load, blood pressure, fasting blood sugar and biomarkers of insulin resistance among adults: Findings from an updated systematic review and meta‐analysis

2020 ◽  
Vol 74 (4) ◽  
Author(s):  
Parvin Dehghan ◽  
Mahdieh Abbasalizad Farhangi
Keyword(s):  
Systematic Review ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Blood Sugar ◽  
Meta Analysis ◽  
Fasting Blood Sugar ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Dietary acid load and cardiometabolic risk factors: a systematic review and meta-analysis of observational studies

2019 ◽  
Vol 22 (15) ◽  
pp. 2823-2834 ◽  
Author(s):  
Elnaz Daneshzad ◽  
Fahimeh Haghighatdoost ◽  
Leila Azadbakht
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Blood Pressure ◽  
Observational Studies ◽  
Cardiometabolic Risk ◽  
Meta Analysis ◽  
Cardiometabolic Risk Factors ◽  
Cross Sectional ◽  
Dietary Acid ◽  
Acid Load

AbstractObjective:Dietary acid load (DAL) might contribute to change the levels of cardiometabolic risk factors; however, the results are conflicting. The present review was conducted to determine the relationship between DAL and cardiometabolic risk factors.Design:Systematic review and meta-analysis.Setting:A systematic search was conducted in electronic databases including ISI Web of Science, PubMed/MEDLINE, Scopus and Google Scholar for observational studies which assessed cardiometabolic risk factors across DAL. Outcomes were lipid profile, glycaemic factors and anthropometric indices. Effect sizes were derived using a fixed- or random-effect model (DerSimonian–Laird). Also, subgroup analysis was performed to find the probable source of heterogeneity. Egger’s test was performed for finding any publication bias.Results:Thirty-one studies were included in the current review with overall sample size of 92 478. There was a significant relationship between systolic blood pressure (SBP; weighted mean difference (WMD) = 1·74 (95 % CI 0·25, 3·24) mmHg;P= 0·022;I2= 95·3 %), diastolic blood pressure (DBP; WMD = 0·75 (95 % CI 0·07, 1·42) mmHg;P= 0·030;I2= 80·8 %) and DAL in cross-sectional studies. Serum lipids, glycaemic parameters including fasting blood sugar, glycated Hb, serum insulin, homeostatic model assessment of insulin resistance and waist circumference had no significant relationship with DAL. No publication bias was found. BMI was not associated with DAL in both cross-sectional and cohort studies.Conclusions:Higher DAL is associated with increased SBP and DBP. More studies are needed to find any relationship of DAL with lipid profile and glycaemic factors.

Dietary acid load and risk of hypertension: A systematic review and dose-response meta-analysis of observational studies

2019 ◽  
Vol 29 (7) ◽  
pp. 665-675 ◽  
Author(s):  
Mohammad Parohan ◽  
Alireza Sadeghi ◽  
Morteza Nasiri ◽  
Vahid Maleki ◽  
Mahmoud Khodadost ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Elevated hypertension risk associated with higher dietary acid load: A systematic review and meta-analysis

2019 ◽  
Vol 33 ◽  
pp. 171-177 ◽  
Author(s):  
Shao-wei Chen ◽  
Zi-hui Chen ◽  
Yu-hui Liang ◽  
Ping Wang ◽  
Jie-wen Peng
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Dietary Acid Load ◽  
Hypertension Risk ◽  
Dietary Acid ◽  
Acid Load

scholarly journals Dietary Acid Load and Blood Pressure in Healthy Adults

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Michael Axler ◽  
Andrea Lobene ◽  
Katarina Smiljanec ◽  
Macarena Ramos Gonzalez ◽  
Alexis Mbakwe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Healthy Adults ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

scholarly journals Estimated Dietary Acid Load Is Not Associated with Blood Pressure or Hypertension Incidence in Men Who Are Approximately 70 Years Old

2014 ◽  
Vol 145 (2) ◽  
pp. 315-321 ◽  
Author(s):  
Desiree Luis ◽  
Xiaoyan Huang ◽  
Ulf Riserus ◽  
Per Sjögren ◽  
Bengt Lindholm ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

scholarly journals Interaction Between Dietary Acid Load and IL6 -572 G/C Polymorphism on Blood Pressure Among Postmenopausal Women in Malaysia

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1264-1264
Author(s):  
Sook Yee Lim ◽  
Yoke Mun Chan ◽  
Ramachandran Vasudevan ◽  
Mohd Shariff Zalilah ◽  
Yit Siew Chin
Keyword(s):  
Blood Pressure ◽  
Postmenopausal Women ◽  
Positive Association ◽  
Gene Interaction ◽  
Community Dwelling ◽  
Dietary Intakes ◽  
Significant Positive Association ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Objectives We examined whether IL6 single nucleotide genetic polymorphism modified the association between dietary acid load (DAL) and blood pressure among postmenopausal women in Malaysia. Methods A total of 211 community-dwelling postmenopausal women were recruited. Dietary intakes of participants were assessed using a validated interview-administered semi-quantitative food frequency questionnaire while DAL was estimated using potential renal acid load (PRAL). Agena® MassARRAY genotyping analysis was used to identify the IL6 genotype and blood pressure was measured using a Digital Automatic BP monitor (OMRON HEM-907, Japan). Interaction between DAL and IL6 -572 G/C polymorphism was assessed using linear regression test. Results There was a significant interaction between DAL and IL6 -572 G/C polymorphism on systolic blood pressure (SBP) (Pinteraction = 0.041). A significant positive association between DAL and SBP with stronger relationship in CG and GG genotype carriers compare to CC carriers were observed. On the other hand, there was no significant diet-gene interaction effect on diastolic blood pressure. Conclusions Our findings suggest that the association between DAL and SBP might be influenced by IL6 -572 G/C polymorphism among postmenopausal women. Further work on how IL6 -572 G/C polymorphism influences the association with DAL on hypertension are warranted. Funding Sources Supported by Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education Malaysia, and Putra Grant UPM.

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