Thyroid function in elderly people: The role of subclinical thyroid disorders in cognitive function and mood alterations

2018 ◽  
Vol 72 (10) ◽  
pp. e13254 ◽  
Author(s):  
Alessandro P. Delitala ◽  
Marta Manzocco ◽  
Federico G. Sinibaldi ◽  
Giuseppe Fanciulli
Keyword(s):  
Cognitive Function ◽  
Elderly People ◽  
Thyroid Function ◽  
Thyroid Disorders ◽  
Subclinical Thyroid Disorders

scholarly journals Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals

2011 ◽  
Vol 165 (4) ◽  
pp. 545-554 ◽  
Author(s):  
Renate T de Jongh ◽  
Paul Lips ◽  
Natasja M van Schoor ◽  
Kelly J Rijs ◽  
Dorly J H Deeg ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Subclinical Hypothyroidism ◽  
Population Based ◽  
Thyroid Disorders ◽  
Older Individuals ◽  
Cross Sectional ◽  
Thyroid Medication ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Subclinical Thyroid Disorders

ObjectiveTo what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression, and mortality in older individuals remains a matter of debate.DesignA population-based, prospective cohort of the Longitudinal Aging Study Amsterdam.MethodsTSH and, if necessary, thyroxine and triiodothyronine levels were measured in individuals aged 65 years or older. Participants were classified according to clinical categories of thyroid function. Participants with overt thyroid disease or use of thyroid medication were excluded, leaving 1219 participants for analyses. Outcome measures were physical and cognitive function, depressive symptoms (cross-sectional), and mortality (longitudinal)ResultsSixty-four (5.3%) individuals had subclinical hypothyroidism and 34 (2.8%) individuals had subclinical hyperthyroidism. Compared with euthyroidism (n=1121), subclinical hypo-, and hyper-thyroidism were not significantly associated with impairment of physical or cognitive function, or depression. On the contrary, participants with subclinical hypothyroidism did less often report more than one activity limitation (odds ratio 0.44, 95% confidence interval (CI) 0.22–0.86). After a median follow-up of 10.7 years, 601 participants were deceased. Subclinical hypo- and hyper-thyroidism were not associated with increased overall mortality risk (hazard ratio 0.89, 95% CI 0.59–1.35 and 0.69, 95% CI 0.40–1.20 respectively).ConclusionsThis study does not support disadvantageous effects of subclinical thyroid disorders on physical or cognitive function, depression, or mortality in an older population.

Subclinical Thyroid Disorders, Physical and Cognitive Function, and Mortality in Older Individuals.

2010 ◽  
pp. OR37-6-OR37-6
Author(s):  
RT de Jongh ◽  
P Lips ◽  
NM van Schoor ◽  
KJ Rijs ◽  
DJ Deeg ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Thyroid Disorders ◽  
Older Individuals ◽  
Subclinical Thyroid Disorders

scholarly journals The Correlation Between Hearing Loss, Especially High-Frequency Hearing Loss and Cognitive Decline Among the Elderly

2021 ◽  
Vol 15 ◽  
Author(s):  
Tongxiang Diao ◽  
Xin Ma ◽  
Junbo Zhang ◽  
Maoli Duan ◽  
Lisheng Yu
Keyword(s):  
Hearing Loss ◽  
Cognitive Function ◽  
Elderly People ◽  
High Frequency ◽  
Pure Tone ◽  
Univariate Analysis ◽  
The Elderly ◽  
High Frequency Hearing Loss ◽  
History Of

Objective: The relation between cognition and hearing loss has been increasingly paid high attention, however, few studies have focused on the role of high-frequency hearing loss in cognitive decline. This study is oriented to role of hearing loss especially high-frequency hearing loss in cognitive impairment among elderly people (age ≥ 60 years).Methods: The Montreal Cognitive Assessment Scale (MoCA) and pure tone audiometry were used to investigate the hearing loss and cognitive function of 201 elderly people older than 60 years. Factors possibly related to cognitive impairment including age, years of education, occupation, living conditions, history of otologic diseases, and high blood pressure were registered. This study consisted of two parts. First, univariate analysis and multiple linear regressions were performed to analyze the possible influencing factors of cognitive function among the 201 elderly people. Second, average hearing thresholds of low frequencies (250, 500 Hz), intermediate frequencies (1 k, 2 kHz), and high frequencies (4 k, 8 kHz) were calculated to screen out 40 cases with high-frequency hearing loss alone and 18 cases with normal hearing. Univariate analysis was used to compare the general condition, cognitive function, and each cognitive domain between the two groups, analyzing the relation between high-frequency hearing loss and cognitive function.Result: We found that age, years of education, pure tone average (PTA), occupation, living condition, history of otologic diseases, years of self-reported hearing loss, and hypertension history were related to cognitive function. Furthermore, age, education experience, duration of self-reported hearing loss, and hypertension were independent factors (p < 0.05). PTA was negatively related with attention, orientation, and general cognition (p < 0.05). There were only 18 cases (9.0%) with normal hearing, and 40 cases (19.9%) with abnormal high-frequency hearing alone. The overall cognitive function showed no significant difference between them (p > 0.05); in contrast, the speech and abstract ability were significantly decreased in cases with high-frequency hearing loss (p < 0.05).Conclusion: The increase of PTA among the elderly may affect the overall cognition by reducing attention and orientation. High-frequency hearing loss alone can affect the language and abstract ability to a certain extent, which is worthy of more attention.

Abstract P490: Subclinical Thyroid Disorders and Triglyceride-rich Lipoprotein Particles Concentration. ELSA-Brasil Cohort

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Carolina Janovsky ◽  
Marcio S Bittencourt ◽  
Alessandra C Goulart ◽  
Raul Santos ◽  
Michael J Blaha ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Resonance Spectroscopy ◽  
Thyroid Disorders ◽  
Subclinical Hyperthyroidism ◽  
Lipoprotein Particles ◽  
Triglyceride Rich Lipoprotein ◽  
Subclinical Thyroid Disorders

Background: Subclinical thyroid disorders have been associated with atherosclerosis and increased cardiovascular risk. Subclinical hypothyroidism is associated with higher levels of total cholesterol and Low-density lipoprotein cholesterol as well as high levels of triglycerides and low levels of high-density lipoprotein cholesterol. Triglyceride-rich Lipoprotein Particles concentration (TRLP) have recently emerged as a causal factor for atherogenesis. Aim: To evaluate the relationship between Subclinical Hypothyroidism and Subclinical Hyperthyroidism and Triglyceride-rich Lipoprotein Particles. Methods: Participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were classified according to the baseline thyroid function as Subclinical Hypothyroidism, Euthyroidism, and Subclinical Hyperthyroidism. Conventional lipid concentrations (total, HDL cholesterol, and triglycerides were determined by a nonprecipitated colorimetric method. The TRLP subfractions were analyzed through Nuclear Magnetic Resonance spectroscopy. To examine the association between TRLP subfractions and thyroid function, we conducted a multivariate linear regression model adjusted for demographic characteristics (race, gender, and educational level), body-mass index, diabetes, smoking status, and alcoholic beverages intake. Results: Of 3,550 individuals free of cardiovascular or thyroid diseases (54%, women; median age 51 years; 51% White, and 53% with at least college education) 92%of them were euthyroid, 6.8% had subclinical hypothyroidism, and 1.2% had subclinical hyperthyroidism. No differences were observed concern the levels of total, HDL, and LDL-cholesterol, but triglycerides were higher for people with Subclinical Hypothyroidism. After adjustment by the covariates described above and using subjects with normal thyroid function as the reference group, for people with Subclinical hypothyroidism a difference of means ( and 95% Confidence Interval) for Total TRLP levels (in ng/L) obtained was 0.06 (-0.00 to 0.13), and for the TRLP subfractions elevated for Very-Small [0.16 (0.02 to 0.28)] and Very-Large [0.21 (0.05 to 0.36)], and similar values for Small [-0.01 (-0.13 to 0.12)]; Medium [0.05 (-0.08 to 0.17)] and Large [0.16 (-0.06 to 0.38)] subfractions. In Subclinical Hyperthyroidism, there was a reduction in Total TRLP (-0.24 (-0.40 - -0.08)), seemingly driven by reduced Very Small-TRLP (0.23 (-0.11 - 0.57). Conclusion: This study suggests that subclinical hypothyroidism is associated with high levels of Very-Small and Very-Large TRLP, which are related to an unfavorable atherogenic profile. Subclinical Hyperthyroidism is associated with low concentrations of Very-Small TRLP.

Investigation of the Free and Total Thyroxine-binding Capacity of Plasma Proteins in Thyroid Disorders

1971 ◽  
Vol 10 (04) ◽  
pp. 299-304
Author(s):  
József Takó ◽  
János Fischer ◽  
Jusztina Juhász ◽  
Ilona Sztraka ◽  
István Kapus ◽  
...  
Keyword(s):  
Blood Cell ◽  
Thyroid Function ◽  
Oral Contraceptives ◽  
Red Blood Cell ◽  
Plasma Proteins ◽  
Binding Capacity ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Total Thyroxine

SummaryThe results of thyroid function tests have been compared with data on the thyroxine-binding capacity of plasma proteins in hyper-, hypo- and euthyroid cases, the latter including women taking oral contraceptives (Infecundin). It was found that there exists a significant correlation of exponential nature between the in vitro red blood cell 125I-triiodothyronine uptake (RCU) and the free thyroxine-binding capacity of the thyroxine-inding globulin (TBG).

scholarly journals Creatine Supplementation and Brain Health

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 586 ◽  
Author(s):  
Hamilton Roschel ◽  
Bruno Gualano ◽  
Sergej M. Ostojic ◽  
Eric S. Rawson
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Function ◽  
Cognitive Processing ◽  
Brain Function ◽  
Creatine Supplementation ◽  
Short Review ◽  
Future Research ◽  
Brain Health

There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.

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