Amorphous silica nanoparticles derived from biowaste via microwave combustion for drug delivery

2020 ◽  
Author(s):  
P. Araichimani ◽  
G. Suresh Kumar ◽  
K.M. Prabu ◽  
Gopalu Karunakaran ◽  
N. Van Minh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Microwave Combustion

scholarly journals In VitroEvaluation of Cytotoxicity of Colloidal Amorphous Silica Nanoparticles Designed for Drug Delivery on Human Cell Lines

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Venugopal Balakrishnan ◽  
Hajarul Azwana Ab Wab ◽  
Khairunisak Abdul Razak ◽  
Shaharum Shamsuddin
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Cell Lines ◽  
Human Body ◽  
Amorphous Silica ◽  
Drug Delivery Systems ◽  
Micelle Formation ◽  
Delivery Systems ◽  
Dependent Manner ◽  
20 Nm

Silica nanoparticles are being developed and tested vigorously in drug delivery systems to treat various diseases. There are many advantages of using silica nanoparticles as a nanodelivery system because they are relatively inexpensive to produce, chemically inert, thermally stable and can be tailored to contain porous structures for drug encapsulation and to be hydrophilic for higher solubility in the human body. Despite these tremendous benefits, one of the pivotal requirements of these drug delivery systems is to be biocompatible with the human body. In this study, the cytotoxicity of colloidal amorphous silica nanoparticles synthesized using the micelle formation method has been tested against normal human foreskin fibroblast cell line (Hs27) as well as selected human bone carcinoma (U-2 OS), human breast cancer (MCF-7), and human cervical carcinoma (HeLa) and (Ca Ski) cell lines to determine the IC50 values. Two different sizes of silica nanoparticles, 20 nm and 40 nm, were used to study the relationship between their size and the level of toxicity exerted on the different cells being tested. The cytotoxicity results indicated that 20 nm and 40 nm silica nanoparticles significantly reduce cell viability in a dose- and cell-type-dependent manner in the normal and cancerous cells tested.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

scholarly journals Insights on toxicity, safe handling and disposal of silica aerogels and amorphous nanoparticles

2021 ◽  
Author(s):  
João P. Vareda ◽  
Carlos A. García-González ◽  
Artur J. M. Valente ◽  
Rosana Simón-Vázquez ◽  
Marina Stipetic ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Silica Aerogels ◽  
Safe Handling ◽  
Synthetic Amorphous Silica ◽  
Amorphous Nanoparticles

The toxicity and ecotoxicity effects, handling and disposal of synthetic amorphous silica nanoparticles and aerogels are reviewed and discussed.

Pollen-like silica nanoparticles as a nanocarrier for tumor targeted and pH-responsive drug delivery

Talanta ◽  
2021 ◽  
Vol 231 ◽  
pp. 122402
Author(s):  
Rongrong Jin ◽  
Jiaxi Wang ◽  
Mingxia Gao ◽  
Xiangmin Zhang
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Ph Responsive

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

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