An innovative Azadirachta indica gum‐mediated synthesis of cocoon‐shaped nano‐AgHAp from Lamellidens marginalis shells

2020 ◽  
Vol 17 (4) ◽  
pp. 2008-2016
Author(s):  
Saravanakumar Ponnusamy ◽  
Sutha Sadhasivam ◽  
Kavitha Louis ◽  
Manoravi Periasamy ◽  
Gopi Dhanaraj
Keyword(s):  
Azadirachta Indica ◽  
Azadirachta Indica Gum

scholarly journals Formulation of Non-effervescent Floating Dosage Form of Metronidazole using Sintering and Sublimation Technique

2021 ◽  
Vol 20 (1) ◽  
pp. 11-17
Author(s):  
Airemwen Collins Ovenseri ◽  
Uhumwangho Uwumagbe Michael
Keyword(s):  
Sustained Release ◽  
Azadirachta Indica ◽  
Dosage Form ◽  
Lag Time ◽  
Ammonium Bicarbonate ◽  
Wet Granulation ◽  
Tableting Machine ◽  
Dsc Studies ◽  
Azadirachta Indica Gum ◽  
Sublimation Technique

The aim of this study was to formulate a novel non-effervescent floating dosage form of metronidazole using the sublimation and sintering technique. Granules were formulated using the wet granulation technique. Ammonium bicarbonate (30% w/w) was incorporated as the sublimating agent. The granules were characterized for micromeritic properties. Thereafter, the granules were compressed using a single punch tableting machine and the physicotechnical properties were evaluated. The metronidazole tablet was then sintered at 70oC for 12 h. All granules were free flowing and compressible. The metronidazole tablets had no floating lag time showing that tablets floated instantaneously. FTIR and DSC studies showed that metronidazole and the excipients used in the formulation were compatible. Azadirachta indica gum was used in the formulation of non-effervescent floating dosage form of metronidazole using sublimation and sintering technique which is beneficial in sustained release formulations. Dhaka Univ. J. Pharm. Sci. 20(1): 11-17, 2021 (June)

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