scholarly journals The role of thromboxane prostanoid receptor signaling in gastric ulcer healing

2021 ◽  
Author(s):  
Sakiko Yamane ◽  
Hideki Amano ◽  
Yoshiya Ito ◽  
Tomohiro Betto ◽  
Yoshio Matsui ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Receptor Signaling ◽  
Gastric Ulcer Healing ◽  
Prostanoid Receptor

Role of nuclear factor-κB in gastric ulcer healing in rats

2001 ◽  
Vol 280 (6) ◽  
pp. G1296-G1304 ◽  
Author(s):  
Satoru Takahashi ◽  
Takuya Fujita ◽  
Akira Yamamoto
Keyword(s):  
Gastric Ulcer ◽  
Mrna Expression ◽  
Ulcer Healing ◽  
Nuclear Factor Κb ◽  
Normal Mucosa ◽  
Cyclooxygenase 2 ◽  
Interleukin 1Β ◽  
Nuclear Factor ◽  
Gastric Ulcer Healing

We investigated the role of nuclear factor-κB (NF-κB) in gastric ulcer healing in rats. NF-κB was activated in ulcerated tissue but not in normal mucosa, and the level of the activation was decreased with ulcer healing. NF-κB activation was observed in fibroblasts, monocytes/macrophages, and neutrophils. Treatment of gastric fibroblasts, isolated from the ulcer base, with interleukin-1β activated NF-κB and the subsequently induced cyclooxygenase-2 and cytokine-induced neutrophil chemoattractant-1 (CINC-1) mRNA expression. Inhibition of activated NF-κB action resulted in suppression of both their mRNA expression and increases in PGE2 and CINC-1 levels induced by interleukin-1β. Persistent prevention of NF-κB activation caused an impairment of ulcer healing in rats. Gene expression of interleukin-1β, CINC-1, cyclooxygenase-2, and inducible nitric oxide synthase in ulcerated tissue had been inhibited before the delay in ulcer healing became manifest. The increased levels of cyclooxygenase-2 protein and PGE2 production were also reduced. These results demonstrate that NF-κB, activated in ulcerated tissue, might upregulate the expression of healing-promoting factors responsible for gastric ulcer healing in rats.

986 The Role of Autophagy in Gastric Epithelial Cell Restitution and Reepithelialization in Gastric Ulcer Healing

2013 ◽  
Vol 144 (5) ◽  
pp. S-181
Author(s):  
Tetsuya Tanigawa ◽  
Toshio Watanabe ◽  
Koji Otani ◽  
Yuji Nadatani ◽  
Shogo Takeda ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Epithelial Cell ◽  
Ulcer Healing ◽  
Gastric Epithelial Cell ◽  
Gastric Ulcer Healing

The Role of Methylglyoxal-Modified Proteins in Gastric Ulcer Healing

2012 ◽  
Vol 19 (1) ◽  
pp. 137-144 ◽  
Author(s):  
T. Takagi ◽  
Y. Naito ◽  
T. Oya-Ito ◽  
T. Yoshikawa
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Gastric Ulcer Healing ◽  
Modified Proteins
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