scholarly journals Effect of tamoxifen on fibrosis, collagen content and transforming growth factor-β1, -β2 and -β3 expression in common bile duct anastomosis of pigs

2017 ◽  
Vol 98 (5) ◽  
pp. 269-277 ◽  
Author(s):  
Orlando Hiroshi Kiono Siqueira ◽  
Karen Jesus Oliveira ◽  
Angela Cristina Gouvêa Carvalho ◽  
Antonio Claudio Lucas da Nóbrega ◽  
Renata Frauches Medeiros ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Collagen Content ◽  
Bile Duct Anastomosis

Metformin reduces hepatic resistance and portal pressure in cirrhotic rats

2015 ◽  
Vol 309 (5) ◽  
pp. G301-G309 ◽  
Author(s):  
Dinesh M. Tripathi ◽  
Eva Erice ◽  
Erica Lafoz ◽  
Héctor García-Calderó ◽  
Shiv K. Sarin ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Growth Factor ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Vascular Resistance ◽  
Cell Activation ◽  
Transforming Growth Factor ◽  
Stellate Cell ◽  
Portal Pressure ◽  
Functional Components

Increased hepatic vascular resistance is the primary factor in the development of portal hypertension. Metformin ameliorates vascular cells function in several vascular beds. Our study was aimed at evaluating the effects, and the underlying mechanisms, of metformin on hepatic and systemic hemodynamics in cirrhotic rats and its possible interaction with the effects of propranolol (Prop), the current standard treatment for portal hypertension. CCl4-cirrhotic rats received by gavage metformin 300 mg/kg or its vehicle once a day for 1 wk, before mean arterial pressure (MAP), portal pressure (PP), portal blood flow (PBF), hepatic vascular resistance, and putative molecular/cellular mechanisms were measured. In a subgroup of cirrhotic rats, the hemodynamic response to acute Prop (5 mg/kg iv) was assessed. Effects of metformin ± Prop on PP and MAP were validated in common bile duct ligated-cirrhotic rats. Metformin-treated CCl4-cirrhotic rats had lower PP and hepatic vascular resistance than vehicle-treated rats, without significant changes in MAP or PBF. Metformin caused a significant reduction in liver fibrosis (Sirius red), hepatic stellate cell activation (α-smooth muscle actin, platelet-derived growth factor receptor β polypeptide, transforming growth factor-βR1, and Rho kinase), hepatic inflammation (CD68 and CD163), superoxide (dihydroethidium staining), and nitric oxide scavenging (protein nitrotyrosination). Prop, by decreasing PBF, further reduced PP. Similar findings were observed in common bile duct ligated-cirrhotic rats. Metformin administration reduces PP by decreasing the structural and functional components of the elevated hepatic resistance of cirrhosis. This effect is additive to that of Prop. The potential impact of this pharmacological combination, otherwise commonly used in patients with cirrhosis and diabetes, needs clinical evaluation.

583: Transforming Growth Factor β1 and its Receptors are Related to the Development, Recurrence and Prgression of Human Bladder Cancers

2005 ◽  
Vol 173 (4S) ◽  
pp. 159-159
Author(s):  
Wun-Jae Kim ◽  
ChangYi Quan ◽  
Pil-Du Jeoung ◽  
Eun-Jung Kim ◽  
Ji-Yeon Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Human Bladder
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