scholarly journals Nitrogen-containing bisphosphonate therapy: assessment of the alveolar bone structure in rats - a blind randomized controlled trial

2015 ◽  
Vol 96 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Viviane N. Pacheco ◽  
Renan Langie ◽  
Adriana Etges ◽  
Deise Ponzoni ◽  
Edela Puricelli
Keyword(s):  
Randomized Controlled Trial ◽  
Alveolar Bone ◽  
Bone Structure ◽  
Controlled Trial ◽  
Bisphosphonate Therapy ◽  
Therapy Assessment ◽  
Randomized Controlled

scholarly journals Effect of Vitamin D on Canine Distalization and Alveolar Bone Density Using Multi-slice Spiral CT: A Randomized Controlled Trial

2019 ◽  
Vol 20 (12) ◽  
pp. 1430-1435
Author(s):  
Venith J Pulikkottil ◽  
Lakshmi Lakshmanan ◽  
Sanju T Varughese ◽  
Pavithra U Shamanna ◽  
Neeraj Goyal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Bone Density ◽  
Alveolar Bone ◽  
Controlled Trial ◽  
Spiral Ct ◽  
Randomized Controlled ◽  
Canine Distalization

scholarly journals Independent and Combined Effects of Calcium-Vitamin D3 and Exercise on Bone Structure and Strength in Older Men: An 18-Month Factorial Design Randomized Controlled Trial

2011 ◽  
Vol 96 (4) ◽  
pp. 955-963 ◽  
Author(s):  
Sonja Kukuljan ◽  
Caryl A. Nowson ◽  
Kerrie M. Sanders ◽  
Geoff C. Nicholson ◽  
Markus J. Seibel ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Vitamin D3 ◽  
Bone Structure ◽  
Controlled Trial ◽  
Older Men ◽  
Combined Effects ◽  
Mineral Density ◽  
Randomized Controlled ◽  
Fortified Milk ◽  
Skeletal Site

Abstract Context: Exercise and calcium-vitamin D are independently recognized as important strategies to prevent osteoporosis, but their combined effects on bone strength and its determinants remain uncertain. Objective: To assess whether calcium-vitamin D3 fortified milk could enhance the effects of exercise on bone strength, structure, and mineral density in middle-aged and older men. Design, Setting, Participants: An 18-month factorial design randomized controlled trial in which 180 men aged 50–79 years were randomized to the following: exercise + fortified milk; exercise; fortified milk; or controls. Exercise consisted of progressive resistance training with weight-bearing impact activities performed 3 d/week. Men assigned to fortified milk consumed 400 ml/d of 1% fat milk containing 1000 mg/d calcium and 800 IU/d vitamin D3. Main Outcome Measures: Changes in bone mineral density (BMD), bone structure, and strength at the lumbar spine (LS), proximal femur, mid-femur, and mid-tibia measured by dual energy x-ray absorptiometry and/or quantitative computed tomography. Results: There were no exercise-by-fortified milk interactions at any skeletal site. Main effect analysis showed that exercise led to a 2.1% (95% confidence interval, 0.5–3.6) net gain in femoral neck section modulus, which was associated with an approximately 1.9% gain in areal BMD and cross-sectional area. Exercise also improved LS trabecular BMD [net gain 2.2% (95% confidence interval, 0.2–4.1)], but had no effect on mid-femur or mid-tibia BMD, structure, or strength. There were no main effects of the fortified milk at any skeletal site. Conclusion: A community-based multi-component exercise program successfully improved LS and femoral neck BMD and strength in healthy older men, but providing additional calcium-vitamin D3 to these replete men did not enhance the osteogenic response.

scholarly journals Effects of Concentrated Growth Factor on Gingival Thickness in Periodontal Accelerated Osteogenic Orthodontics: A 6-Month Randomized Controlled Trial

2021 ◽  
Author(s):  
Lei Qi ◽  
Weiwen Ge ◽  
Ningning Cao ◽  
Shoupeng Wang ◽  
Yifeng Qian ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Growth Factor ◽  
Alveolar Bone ◽  
Controlled Trial ◽  
Test Group ◽  
Control Group ◽  
Gingival Thickness ◽  
Randomized Controlled ◽  
Intergroup Comparison ◽  
Gingival Phenotype

Abstract Background: Earlier studies have not given clear results of concentrated growth factor (CGF) on gingival thickness (GT) in periodontal accelerated osteogenic orthodontics (PAOO). This randomized controlled trial aimed to evaluate the effects of CGF on GT in patients with thin gingival phenotype undergoing PAOO.Methods: 44 patients with 264 surgical sites were recruited at baseline. All patients were randomly allocated to either a control (collagen matrix memberane) or test (CGF) group and received PAOO. GT, gingival height (GH), buccal alveolar bone thickness (BT), and buccal alveolar bone height (BH) were evaluated depending on cross-sectional CBCT images at t0 (before surgery) and t1(6 months after surgery). Results: GT were increased in both groups at t1 compared to t0. Yet, higher values were observed in the test group (from 0.95±0.26 to 1.29±0.34mm) compared to the control group (from 0.92±0.25 to 1.01±0.18mm) (p < 0.05). Moreover, in the intergroup comparison, GT at t1 in the test group was significantly higher compared to the control group (p < 0.01). Furthermore, the GT of central incisors, lateral incisors and canine teeth all showed significantly changes compared with baseline and the test group showed higher increase (p < 0.01). No statistically significant difference were found in GH, BT, BH and all clinical parameters between two groups at t1 (p > 0.05). Conclusions: Within the limitation of this study, gingival thickness could be increased by using CGF in PAOO for the patients with thin gingival phenotype. Trial registration The study was registered in Chinese Clinical Trial Registry（http://www.chictr.org.cn/index.aspx）under the number ChiCTRINR17013346, Registered 11 November 2017.

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