Immunoexpression of tumour necrosis factor-α, interleukin-1α and interleukin-10 on odontogenic cysts and tumours

2016 ◽  
Vol 50 (5) ◽  
pp. 437-445 ◽  
Author(s):  
M. C. Sá ◽  
F. R. de Matos ◽  
T. S. Conceição ◽  
A. C. G. H. Leitão ◽  
R. A. Freitas
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Interleukin 10 ◽  
Odontogenic Cysts ◽  
Tumour Necrosis Factor Α ◽  
Interleukin 1Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumour necrosis factor-α/interleukin-10 ratio in patients with obstructive sleep apnoea hypopnoea syndrome

2014 ◽  
Vol 129 (1) ◽  
pp. 73-78 ◽  
Author(s):  
H Jiang ◽  
H Cao ◽  
P Wang ◽  
W Liu ◽  
F Cao ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Obstructive Sleep Apnoea ◽  
Tumour Necrosis ◽  
Positive Airway Pressure ◽  
Interleukin 10 ◽  
Sleep Apnoea ◽  
Tumour Necrosis Factor Α ◽  
Obstructive Sleep ◽  
Factor Α ◽  
Necrosis Factor

AbstractObjective:To explore the significance of the tumour necrosis factor-α/interleukin-10 ratio and the effect of continuous positive airway pressure in patients with different degrees of obstructive sleep apnoea hypopnoea syndrome severity.Method:This study comprised 135 patients with obstructive sleep apnoea hypopnoea syndrome and 94 control subjects.Results:Tumour necrosis factor-α and tumour necrosis factor-α/interleukin-10 ratio values were significantly higher in the obstructive sleep apnoea hypopnoea syndrome group than in the control group, but interleukin-10 was significantly lower. Tumour necrosis factor-α/interleukin-10 ratio values increased in line with the severity of obstructive sleep apnoea hypopnoea syndrome. In multivariate analysis, the tumour necrosis factor-α/interleukin-10 ratio correlated positively with the apnoea–hypopnoea index and all indices of obstructive sleep apnoea hypopnoea syndrome, except for age, body mass index and neck circumference. After one month of continuous positive airway pressure therapy, levels of tumour necrosis factor-α decreased; interleukin-10 showed no change.Conclusion:The results suggest that inflammation is activated and anti-inflammatory cytokines are decreased in obstructive sleep apnoea hypopnoea syndrome patients. Tumour necrosis factor-α/interleukin-10 ratio may prove useful for severity monitoring and management of obstructive sleep apnoea hypopnoea syndrome patients, and may reduce the need for polysomnography.

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