Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water-soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. A randomized clinical trial

2015 ◽  
Vol 15 (1) ◽  
pp. 53-64 ◽  
Author(s):  
D Rusu ◽  
S-I Stratul ◽  
C Sarbu ◽  
A Roman ◽  
A Anghel ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Chronic Periodontitis ◽  
Water Soluble ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Chlorhexidine Gel

scholarly journals Assessment of the Effect of Photodynamic Therapy on Treatment of Moderate-to-Severe Periodontitis; a Randomized Clinical Trial Study

2016 ◽  
Vol 9 (4) ◽  
pp. 83
Author(s):  
Babak Amoian ◽  
Aida Mirzaee ◽  
Seyed Mostafa Hosseini
Keyword(s):  
Clinical Trial ◽  
Photodynamic Therapy ◽  
Randomized Clinical Trial ◽  
Chronic Periodontitis ◽  
Time Interval ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Bleeding On Probing ◽  
Treatment Groups ◽  
Root Planing

<p><strong>BACKGROUND &amp; AIM: </strong>Photodynamic therapy is a localized non-invasive treatment modality for the periodontal disease. Some evidences have shown that this technique is effective in improving the treatment outcome. This study compared the effects of photodynamic therapy with and without scaling and root planing and scaling and root planing alone on the clinical parameters of the chronic periodontitis.</p><p><strong>MATERIALS &amp; METHODS: </strong>In this single-blind, randomized clinical trial, 30 chronic periodontitis patients (10 for each modality) were selected and three different methods; photodynamic therapy alone (Group1) by FotoSan 630 system, scaling and root planning (SRP) alone (Group2), scaling and root planing combined with photodynamic therapy (Group3) were done for them randomly. Clinical parameters of probing pocket depth (PPD), bleeding on probing (BOP), and clinical attachment level (CAL) were measured at the baseline and 3, 6 and 12 weeks later. One-sided analysis of variance test was used to analyze PPD and CAL among the treatment groups in each time interval while the paired comparisons were carried out by employment of Dunnett’s test. The treatment groups were statically analyzed by the chi-square test regarding BOP. <strong></strong></p><p><strong>RESULTS: </strong>Before the treatment; no significant differences observed among treatment modalities regarding clinical parameters; while the differences were significant at three weeks (p&lt;0.0001 for PPD and CAL; p&lt;0.001 for BOP); six weeks (p&lt;0.0001 for PPD and CAL, p&lt;0.002 for BOP); and 12 weeks after the treatment (all: p&lt;0.0001). The least PPD and CAL values and the most frequency of non-bleeding on probing status were measured for PDT+SRP modality at three, six, and twelve weeks after the treatment.</p><p><strong>CONCLUSION: </strong>Photodynamic therapy supported the clinical parameters of periodontitis similar to SRP; however, PDT combined with SRP demonstrated a better result than that of SRP alone. Therefore, PDT combined with SRP can be used to improve outcomes of clinical parameters of periodontitis as compared to SRP alone in the short-term.</p>

scholarly journals Efficacy of (−)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yanfeng Wang ◽  
Jiajun Zeng ◽  
Qiao Yuan ◽  
Qingxian Luan
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Chronic Periodontitis ◽  
Combined Treatment ◽  
Epigallocatechin Gallate ◽  
Scaling And Root Planing ◽  
Clinical Trial Registry ◽  
Root Planing ◽  
New Type ◽  
And Control

Abstract Background (−)-Epigallocatechin Gallate (EGCG) as green tea catechins possessed antibacterial and anti-inflammatory effects on periodontal disease. This study was designed to evaluate the clinical and microbiological efficacy of scaling and root planing (SRP) using EGCG aqueous solution as coolants through a new-type ultrasonic scaler tip on chronic periodontitis. Methods This split-mouth, randomized clinical trial included 20 patients (2 drop-outs) with chronic periodontitis and the maxillary contra-lateral sides were allocated into test and control groups randomly. Through the new-type scaler tip, 762 sites with probing depth (PD) ≥ 4 mm were treated by SRP using EGCG solution or distilled water as coolants respectively. Clinical parameters and red complex pathogens in subgingival microbiome were evaluated at baseline, 3 and 6 months after treatments. Results During 6 months, the SRP plus EGCG medication contributed to additional PD reduction as 0.33 mm and gain of clinical attachment level as 0.3 mm compared with SRP alone, and approximate 8% more sites obtained PD reduction ≥ 2 mm (p < 0.05). Meanwhile, the mean relative abundance of Tannerella forsythia was significantly lower in the combined treatment group (p < 0.05). Conclusion The purified EGCG showed the potential to improve the outcome of periodontal non-surgical treatment and the new-type scaler tip provided an alternative vehicle for subgingival medication. Trial registration The trial was registered in Chinese Clinical Trial Registry on 15 February 2020 (No.: ChiCTR2000029831, retrospectively registered). http://www.chictr.org.cn/showprojen.aspx?proj=49441.

TOPICAL CHEMOTHERAPEUTIC ADJUNCTS IN NON-SURGICAL PERIODONTAL THERAPY – A RANDOMISED CONTROLLED DOUBLE BLINDED TRIAL.

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Upendra Prasad ◽  
Abhinav Deshpande ◽  
Praneeta Kamble ◽  
Abhishek Singh ◽  
Adiya Apon ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Comparable Efficacy ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Root Planing ◽  
Intergroup Comparison ◽  
Significant Difference ◽  
Group A ◽  
Chlorhexidine Gel

Introduction: Topical chemotherapeutic agents used in treatment of chronic periodontitis are antimicrobial agents which help in plaque control. The present study evaluates the efficacy of ornidazole gel with gold standard chlorhexidine gel when used as adjunct to scaling and root planing. Material and Methods: 90 patients diagnosed as chronic periodontitis, having pocket depth ?3 mm and in good systemic health were selected by systematic sampling method and divided in 3 groups. In all 3 groups scaling and root planing was done. In group A, Ornidazole gel application was done while in Group B Chlorhexidine gel application was done while Group C was control group. Plaque Index (PI) and Gingival Index (GI) were recorded at baseline, 1 and 3 months while Probing pocket depth (PPD) and Clinical attachment level (CAL) were recorded at baseline and 3 months. Results: PI and GI showed significant reduction in all three groups after 1 and 3 months compared to baseline. On inter group comparison, both PI and GI showed no significant difference in reduction of scores after 1 month and 3 months (p>0.05). PPD and CAL values showed statistically significant reduction after 3 months when compared to baseline values. The intergroup comparison revealed statistically significant reduction in group A and B compared to control group C (p<0.05). Conclusion: Ornidazole showed comparable efficacy as Chlorhexidine when used as adjunct to scaling and root planing for treatment of chronic periodontitis.

Adjunctive Effects of Systemic Amoxicillin and Metronidazole with Scaling and Root Planing: A Randomized, Placebo Controlled Clinical Trial

2007 ◽  
Vol 8 (5) ◽  
pp. 51-59 ◽  
Author(s):  
Amir Moeintaghavi ◽  
Mohammad Reza Talebi-ardakani ◽  
Ahmad Haerian-ardakani ◽  
Hengame Zandi ◽  
Shokouh Taghipour ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Periodontitis ◽  
Controlled Clinical Trial ◽  
Scaling And Root Planing ◽  
Double Blind ◽  
Root Planing ◽  
Number Of Patients ◽  
Significant Difference ◽  
Microbiological Testing ◽  
Clinical Changes

Abstract Aims Aims: The objective of this study was to investigate the effect of the systemic administration of metronidazole and amoxicillin as an adjunct to initial periodontal therapy in patients with moderate to severe chronic periodontitis. Methods and Materials This randomized, double blind, placebo controlled parallel study involved 50 adult patients with untreated periodontitis who were randomly assigned to receive either a full-mouth scaling and root planing along with systemic metronidazole and amoxicillin (T group) or scaling and root planing with a placebo (P group). Clinical measurements including probing depth (PD), clinical attachment levels (CAL), Plaque Index (PI), and Bleeding Index (BI) were recorded at baseline and six to eight weeks after therapy. The deepest pocket was selected and samples for microbiological testing were taken. Patients received coded study medications of either 500 mg amoxicillin in combination with 250 mg metronidazole or an identical placebo every eight hours for seven days following scaling and root planing. Results There was a significant change in PD (P=0.0001), CAL (P=0.00001), PI (P<0.05), and BI (P<0.05) in the T group compared to the placebo group after therapy. Parallel to the clinical changes, treatment significantly reduced the number of Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and P. intermedia (Pi) compared with baseline in the T group (P=0.003, 0.021 and 0.0001, respectively). However, in the P group only the Pi colony count was reduced significantly (P=0.0001). After therapy, there was a significant difference between the T and P groups in the number of patients negative for Aa, Pg, and Pi (Pv = 0.033). Conclusions The significant differences between treatment and placebo groups are in line with other studies and support the considerable adjunctive benefits of the combination of amoxicillin and metronidazole in the treatment of chronic periodontitis. Citation Moeintaghavi A, Talebi-ardakani MR, Haerian-ardakani A, Zandi H, Taghipour S, Fallahzadeh H, Pakzad A, Fahami N. Adjunctive Effects of Systemic Amoxicillin and Metronidazole with Scaling and Root Planing: A Randomized, Placebo Controlled Clinical Trial. J Contemp Dent Pract 2007 July;(8)5:051-059.

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