scholarly journals Multipotentiality of skin‐derived precursors: application to the regeneration of skin and other tissues

2020 ◽  
Vol 42 (1) ◽  
pp. 5-15 ◽  
Author(s):  
L. Bergeron ◽  
V. Busuttil ◽  
J.‐M. Botto
Keyword(s):  
Regeneration Of Skin

Sorbitol-penetration enhancer containing vesicles loaded with baicalin for the protection and regeneration of skin injured by oxidative stress and UV radiation

2019 ◽  
Vol 555 ◽  
pp. 175-183 ◽  
Author(s):  
Maria Letizia Manca ◽  
Silvia Mir-Palomo ◽  
Carla Caddeo ◽  
Amparo Nacher ◽  
Octavio Díez-Sales ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uv Radiation ◽  
Penetration Enhancer ◽  
Regeneration Of Skin

Angiogenic Synergistic Effect of Adipose-Derived Stromal Cell Spheroids with Low-Level Light Therapy in a Model of Acute Skin Flap Ischemia

2016 ◽  
Vol 202 (5-6) ◽  
pp. 307-318 ◽  
Author(s):  
In-Su Park ◽  
Phil-Sang Chung ◽  
Jin Chul Ahn
Keyword(s):  
Growth Factors ◽  
Skin Flap ◽  
Light Therapy ◽  
Skin Flaps ◽  
Low Level Light Therapy ◽  
Low Level ◽  
Cell Source ◽  
Hematoxylin And Eosin ◽  
Recipient Tissue ◽  
Regeneration Of Skin

Human adipose-derived mesenchymal stem cells (hASCs) are an attractive cell source for tissue engineering. However, one obstacle to this approach is that the transplanted hASC population can decline rapidly in the recipient tissue. The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted spheroid hASCs in skin flaps of mice. hASCs were cultured in monolayers or spheroids. LLLT, hASCs, spheroids and spheroids transplanted with LLLT were applied to the skin flaps. Healing of the skin flaps was assessed by gross evaluation and by hematoxylin and eosin staining and elastin van Gieson staining. Compared with the spheroid group, skin flap healing was enhanced in the spheroid + LLLT group, including the neovascularization and regeneration of skin appendages. The survival of hASCs was enhanced by decreased apoptosis of hASCs in the skin flaps of the spheroid + LLLT group. The secretion of growth factors was stimulated in the spheroid + LLLT group compared with the ASC and spheroid groups. These data suggest that LLLT was an effective biostimulator of spheroid hASCs in the skin flaps, enhancing the survival of hASCs and stimulating the secretion of growth factors.

Approaches to Tissue Engineering

2004 ◽  
Author(s):  
W. Mark Saltzman
Keyword(s):  
Biological Sciences ◽  
Tissue Engineering ◽  
Early Stage ◽  
Organizational Structures ◽  
Engineering Practice ◽  
Stage Of Development ◽  
Synthetic Materials ◽  
New Knowledge ◽  
Tissue Systems ◽  
Regeneration Of Skin

The first part of this book has proposed that tissue engineering is a modern realization of a practice with ancient origins. Tissue engineering is different because technologies that are now available permit generation of synthetic materials that mimic biological materials as well as clinically useful quantities of biological components (such as proteins and cells). These technologies have emerged from rapid advances in the biological sciences and engineering over the past few decades. Since tissue engineering is new, however, few examples of successful tissue engineering are available. The reader, upon recognizing this early stage of development, might presume that the prospects for a compelling chapter on “Approaches to Tissue Engineering” are bleak. Instead, I am convinced that this is the most exciting of times to write such a chapter, because the precedents are not yet assembled and the field has not yet been reduced to systematic divisions. But there are many challenges. The challenge begins with organization of information. Written reviews of tissue engineering to date adopt different organizational structures. For example, an early influential review was organized around replacement strategies for different organ or tissue systems. A similar, although more encyclopedic, approach was used in the first two editions of an edited textbook. This is a sensible arrangement, given that tissue engineering is an interdisciplinary area of study that has emerged in response to rather specific clinical needs, such as the shortage of donor livers and the paucity of grafts for skin. But it is a difficult arrangement for the teacher and student, as it does not require reconciliation between approaches used to solve different problems. For example, although regeneration of skin and liver differs in many essential ways, there are important areas of intersection. As a consequence, an organ or tissue-based approach does not easily allow for assimilation of new knowledge that is acquired by successes made on particular problems. What is tissue engineering and how can the basic principles, which are developed in Part 2 of this book, be integrated into a strategy for the engineering of replacement tissues? The previous three chapters describe important, but focused, elements of tissue engineering practice: cell delivery, agent delivery, and cell interactions with synthetic materials.

The topography of fibrous scaffolds modulates the paracrine function of Ad-MSCs in the regeneration of skin tissues

2019 ◽  
Vol 7 (10) ◽  
pp. 4248-4259 ◽  
Author(s):  
Ruiying Huang ◽  
Jian Wang ◽  
Haoxiang Chen ◽  
Xuelei Shi ◽  
Xiaocheng Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
3D Printing ◽  
Therapeutic Effect ◽  
Tissue Regeneration ◽  
Skin Tissue ◽  
Fibrous Scaffolds ◽  
Regeneration Of Skin

A tissue engineered skin is designed and fabricated by 3D printing, which has a therapeutic effect on wound healing and skin tissue regeneration.

scholarly journals Regeneration of Skin Tissue Promoted by Mesenchymal Stem Cells Seeded in Nanostructured Membrane

2014 ◽  
Vol 46 (6) ◽  
pp. 1882-1886 ◽  
Author(s):  
C.M.C.O. Souza ◽  
L.A.F. Mesquita ◽  
D. Souza ◽  
A.C. Irioda ◽  
J.C. Francisco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Skin Tissue ◽  
Regeneration Of Skin
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