scholarly journals Organization, barrier function and antimicrobial lipids of the oral mucosa

2013 ◽  
Vol 35 (3) ◽  
pp. 220-223 ◽  
Author(s):  
D. V. Dawson ◽  
D. R. Drake ◽  
J. R. Hill ◽  
K. A. Brogden ◽  
C. L. Fischer ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Barrier Function ◽  
Antimicrobial Lipids

Antimicrobial Lipids of the Skin and Oral Mucosa

2011 ◽  
pp. 73-81
Author(s):  
Kim A. Brogden ◽  
David R. Drake ◽  
Deborah V. Dawson ◽  
Jennifer R. Hill ◽  
Carol L. Bratt ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Antimicrobial Lipids

scholarly journals Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

2021 ◽  
Vol 22 (10) ◽  
pp. 5229
Author(s):  
Philip W. Wertz
Keyword(s):  
Fatty Acids ◽  
Stratum Corneum ◽  
Oral Mucosa ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Toxic Substances ◽  
Lipid Mixture ◽  
Terrestrial Mammals ◽  
Buccal Absorption ◽  
Oral Epithelial

PubMed searches reveal much literature regarding lipids in barrier function of skin and less literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and reptiles, the skin’s permeability barrier is provided by ceramides, fatty acids, and cholesterol in the outermost layers of the epidermis, the stratum corneum. This layer consists of about 10–20 layers of cornified cells embedded in a lipid matrix. It effectively prevents loss of water and electrolytes from the underlying tissue, and it limits the penetration of potentially harmful substances from the environment. In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis. The oral stratum corneum contains a lipid mixture similar to that in the epidermal stratum corneum but in lower amounts and is accordingly more permeable. The superficial regions of the nonkeratinized oral epithelia also provide a permeability barrier. These epithelial regions do contain ceramides, cholesterol, and free fatty acids, which may underlie barrier function. The oral epithelial permeability barriers primarily protect the underlying tissue by preventing the penetration of potentially toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, and lipid-related disease are discussed.

scholarly journals Synopsis of Barrier Function of Skin and Oral Mucosa—Volume 1

2021 ◽  
Vol 22 (17) ◽  
pp. 9383
Author(s):  
Philip W. Wertz
Keyword(s):  
Oral Mucosa ◽  
Barrier Function ◽  
Special Issue

This is an attempt to make readers of the second edition of International Journal of Molecular Sciences Special Issue on the Barrier Function of Skin and Oral Mucosa aware of the content of the first edition on this same topic [...]

scholarly journals The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem Deficiency

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Fawzia Bardag-Gorce ◽  
Richard H. Hoft ◽  
Andrew Wood ◽  
Joan Oliva ◽  
Hope Niihara ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Membrane ◽  
Oral Mucosa ◽  
Barrier Function ◽  
Cell Sheet ◽  
Cellular Adhesion ◽  
Beta Catenin ◽  
Junction Protein ◽  
E Cadherin

The role of E-cadherin in epithelial barrier function of cultured autologous oral mucosa epithelial cell sheet (CAOMECS) grafts was examined. CAOMECS were cultured on a temperature-responsive surface and grafted onto rabbit corneas with Limbal Stem Cell Deficiency (LSCD). E-cadherin levels were significantly higher in CAOMECS compared to normal and LSCD epithelium. Beta-catenin colocalized with E-cadherin in CAOMECS cell membranes while phosphorylated beta-catenin was significantly increased. ZO-1, occludin, and Cnx43 were also strongly expressed in CAOMECS. E-cadherin and beta-catenin localization at the cell membrane was reduced in LSCD corneas, while CAOMECS-grafted corneas showed a restoration of E-cadherin and beta-catenin expression. LSCD corneas did not show continuous staining for ZO-1 or for Cnx43, while CAOMECS-grafted corneas showed a positive expression of ZO-1 and Cnx43. Cascade Blue® hydrazide did not pass through CAOMECS. Because E-cadherin interactions are calcium-dependent, EGTA was used to chelate calcium and disrupt cell adhesion. EGTA-treated CAOMECS completely detached from cell culture surface, and E-cadherin levels were significantly decreased. In conclusion, E cadherin high expression contributed to CAOMECS tight and gap junction protein recruitment at the cell membrane, thus promoting cellular adhesion and a functional barrier to protect the ocular surface.

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

Freeze-etch observations on the tight junctions of sertoli cells grown in organ culture with FSH

1978 ◽  
Vol 36 (2) ◽  
pp. 340-341
Author(s):  
Rita Meyer ◽  
Zoltan Posalaky ◽  
Dennis Mcginley
Keyword(s):  
Organ Culture ◽  
Tight Junctions ◽  
Sertoli Cell ◽  
Germ Cells ◽  
Sertoli Cells ◽  
Barrier Function ◽  
Cell Junction ◽  
Intramembranous Particles ◽  
Junctional Complexes ◽  
Oriented Parallel

The Sertoli cell tight junctional complexes have been shown to be the most important structural counterpart of the physiological blood-testis barrier. In freeze etch replicas they consist of extensive rows of intramembranous particles which are not only oriented parallel to one another, but to the myoid layer as well. Thus the occluding complex has both an internal and an overall orientation. However, this overall orientation to the myoid layer does not seem to be necessary to its barrier function. The 20 day old rat has extensive parallel tight junctions which are not oriented with respect to the myoid layer, and yet they are inpenetrable by lanthanum. The mechanism(s) for the control of Sertoli cell junction development and orientation has not been established, although such factors as the presence or absence of germ cells, and/or hormones, especially FSH have been implicated.

EPEC-activated ezrin participates in signaling that disrupts barrier function

2001 ◽  
Vol 120 (5) ◽  
pp. A109-A109
Author(s):  
I SIMONOVIC ◽  
M ARPIN ◽  
A KOUTSOURIS ◽  
G HECHT
Keyword(s):  
Barrier Function
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