scholarly journals Laparoscopic left lateral resection is the gold standard for benign liver lesions: a case–control study

HPB ◽  
2014 ◽  
Vol 16 (2) ◽  
pp. 183-187 ◽  
Author(s):  
Safi Dokmak ◽  
Vikram Raut ◽  
Béatrice Aussilhou ◽  
Fadhel Samir Ftériche ◽  
Olivier Farges ◽  
...  
Keyword(s):  
Gold Standard ◽  
Case Control Study ◽  
Case Control ◽  
Liver Lesions ◽  
Benign Liver ◽  
Control Study ◽  
Benign Liver Lesions

Investigating Lipoprotein(A) as a Risk Factor for Ischemic Arterial Stroke in U.S. Children. New Understanding from a Case-Control Study with Gold-Standard Laboratory Assessment.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2627-2627
Author(s):  
Neil A. Goldenberg ◽  
R. Knapp-Clevenger ◽  
Linda Jacobson ◽  
Taru Hays ◽  
Santica M. Marcovina ◽  
...  
Keyword(s):  
Risk Factor ◽  
Gold Standard ◽  
Case Control Study ◽  
Case Control ◽  
Diabetes Research ◽  
Healthy Children ◽  
Standard Laboratory ◽  
Elevated Plasma ◽  
Lipoprotein A ◽  
Control Study

Abstract Background: Lipoprotein(a) [Lp(a)] is a plasma lipoprotein that has been implicated in both atherogenesis and thrombophilia. A few reports in recent years, principally in European populations, have suggested that elevated plasma Lp(a) level may constitute a risk factor for ischemic arterial stroke (IAS) in children. However, the ELISA assays used in these studies are technically limited by their ability to provide accurate Lp(a) values independently of apo(a) size. Objective: To determine the prevalence of elevated plasma Lp(a) concentration among children with non-neonatal IAS and healthy children in a U.S. population using the current gold-standard laboratory methodology, toward the evaluation of Lp(a) as a risk factor for pediatric IAS. Methods: In a case-control study, children from 1 month to 21 years of age with a history of radiologically-confirmed IAS (case group, n=22) and healthy children (contemporaneous control group, n=41) were consecutively recruited from The Children’s Hospital, Denver, and the Mountain States Regional Hemophilia and Thrombosis Center (Aurora, CO). Children with IAS who were receiving drugs that affect Lp(a) level, such as niacin or statins, were excluded. Fasting plasma samples were obtained by peripheral venipuncture into EDTA with susequent centrifugation to yield platelet-poor plasma. Lp(a) assay was performed in the Northwest Lipid Metabolism and Diabetes Research Laboratories at the University of Washington, Seattle, using a double monoclonal antibody-based ELISA validated to be sensitive to apo(a) size heterogeneity. Results were expressed in nmol/L of Lp(a) protein, with corresponding race-appropriate percentiles. In accordance with NHLBI recommendations, values above the 75th percentile were considered to indicate increased risk, and were hence designated as elevated. Results: Median Lp(a) concentration did not significantly differ between the two groups (cases: 16.9 nmol/L, controls: 24.7 nmol/L; P=0.96). While the prevalence of elevated Lp(a) levels was increased among children with IAS (cases: 36%, controls: 24%), this difference did not reach statistical significance (P=0.32). The odds of having elevated Lp(a) were nearly two times that of healthy controls (OR=1.8, 95% CI=0.50–6.3); however, this also was not statistically significant. Conclusions: The present study demonstrates a qualitatively increased prevalence of elevated plasma Lp(a) concentration among children with non-neonatal IAS when compared to healthy children, using the gold-standard methodology for Lp(a) assessment. Expansion of the study to a larger population via multicenter collaboration will be necessary to definitively determine whether Lp(a) is a risk factor for IAS in children. Furthermore, given that genetic variation in the apo(a) gene is the major determinant of plasma Lp(a) concentration, apo(a) phenotyping may be useful to better define risk strata. These efforts are an important precursor to interventional studies evaluating Lp(a) management strategies in the secondary prevention of IAS in children.

Prevalence of Extracranial venous Narrowing on Magnetic Resonance Venography is Similar in People with Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study

2017 ◽  
Vol 68 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Nancy Martin ◽  
Anthony L. Traboulsee ◽  
Lindsay Machan ◽  
Darren Klass ◽  
Tasha Ellchuk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Gold Standard ◽  
Venous Insufficiency ◽  
Case Control Study ◽  
Study Groups ◽  
Case Control ◽  
Significant Difference ◽  
High Prevalence ◽  
Control Study

Purpose The study sought to assess and compare the prevalence of narrowing of the major extracranial veins in subjects with multiple sclerosis and controls, and to assess the sensitivity and specificity of magnetic resonance venography (MRV) for describing extracranial venous narrowing as it applies to the chronic cerebrospinal venous insufficiency theory, using catheter venography (CV) as the gold standard. Methods The jugular and azygos veins were assessed with time-of-flight MRV in this assessor-blinded, case-control study of subjects with multiple sclerosis, their unaffected siblings, and unrelated controls. The veins were evaluated by diameter and area, and compared with CV. Collateral vessels were also analyzed for maximal diameter, as a potential indicator of compensatory flow. Results A high prevalence of extracranial venous narrowing was demonstrated in all study groups, collectively up to 84% by diameter criteria and 90% by area, with no significant difference between the groups when assessed independently ( P = .34 and .63, respectively). There was high interobserver variability in the reporting of vessel narrowing (kappa = 0.32), and poor vessel per vessel correlation between narrowing on MRV and CV (kappa = 0.064). Collateral neck veins demonstrated no convincing difference in maximum size or correlation with jugular narrowing. Conclusion There is a high prevalence of narrowing of the major extracranial veins on MRV in all 3 study groups, with no significant difference between them. These findings do not support the chronic cerebrospinal venous insufficiency theory. Although MRV has shown a high sensitivity for identifying venous narrowing, time-of-flight imaging demonstrates poor interobserver agreement and poor specificity when compared with the gold standard CV.

Precursor lesions of gastric polyps developing during maintenance omeprazole. A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A657-A658
Author(s):  
A CATS ◽  
E BLOEMENA ◽  
E SCHENK ◽  
I CLINICS ◽  
S MEUWISSEN ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Precursor Lesions ◽  
Gastric Polyps ◽  
Control Study

Risk factors for esophageal adenocarcinoma: A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
B AVIDAN ◽  
A SONNENBERG ◽  
T SCHNELL ◽  
G CHEJFEC ◽  
A METZ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

130: A Case-Control Study of Medical Co-Morbidities in Women with Interstitial Cystitis

2007 ◽  
Vol 177 (4S) ◽  
pp. 45-45
Author(s):  
J. Quentin Clemens ◽  
Richard T. Meenan ◽  
Maureen C. O’Keeffe Rosetti ◽  
Teresa M. Kimes ◽  
Elizabeth A. Calhoun
Keyword(s):  
Interstitial Cystitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
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