scholarly journals Redefining the R1 resection for pancreatic ductal adenocarcinoma: tumour lymph nodal burden and lymph node ratio are the only prognostic factors associated with survival

HPB ◽  
2013 ◽  
Vol 15 (9) ◽  
pp. 674-680 ◽  
Author(s):  
Biku J. John ◽  
Prashant Naik ◽  
Alastair Ironside ◽  
Brian R. Davidson ◽  
Guiseppe Fusai ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Lymph Node Ratio ◽  
Ductal Adenocarcinoma ◽  
Factors Associated ◽  
R1 Resection ◽  
Node Ratio ◽  
Nodal Burden

Prognostic Implication of pN Stage Subdivision Using Metastatic Lymph Node Ratio in Resected Pancreatic Ductal Adenocarcinoma

2019 ◽  
Vol 28 (3) ◽  
pp. 245-251
Author(s):  
Jung-Soo Pyo ◽  
Nae Yu Kim ◽  
Byoung Kwan Son ◽  
Kwang Hyun Chung
Keyword(s):  
Lymph Node ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Meta Analysis ◽  
Ductal Adenocarcinoma ◽  
Prognostic Implication ◽  
Metastatic Lymph ◽  
Optimal Criterion ◽  
Node Ratio

In this meta-analysis, we aimed to evaluate the prognostic implication of the metastatic lymph node ratio (mLNR) and its optimal criterion in pancreatic ductal adenocarcinoma (PDAC) with lymph node metastasis (LNM). The present study included 3735 patients with PDAC who had LNM, from 11 eligible studies. We carried out a meta-analysis to determine the correlation between a high mLNR and PDAC prognosis. The estimated mean numbers of examined and metastatic lymph nodes were 22.396 (95% confidence interval [CI] = 19.681-25.111) and 6.496 (95% CI = 4.646-8.345), respectively. A high mLNR was significantly correlated with worse overall survival (hazard ratio = 1.344, 95% CI = 1.276-1.416). In 3 subgroups based on high mLNR criteria (>0 and <0.2, ≥0.2 and <0.4, and ≥0.4), there were significant correlations between a high mLNR and worse survival. A cutoff of 0.200 showed the highest hazard ratio (1.391, 95% CI = 1.268-1.525), which was statistically significant. Our results showed that mLNR is a useful prognostic factor for PDAC with LNM. Although the optimal criterion of high mLNR may be 0.200, further cumulative studies are required before this can be applied in daily practice.

scholarly journals Lymph Node Ratio as Predictor of Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S54-S55
Author(s):  
G.-R. Joliat ◽  
I. Labgaa ◽  
J. Sulzer ◽  
D. Vrochides ◽  
A. Zerbi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Lymph Node Ratio ◽  
Ductal Adenocarcinoma ◽  
Node Ratio

Role of the Lymph node ratio in pancreatic ductal adenocarcinoma. Impact on patient stratification and prognosis

2011 ◽  
Vol 104 (6) ◽  
pp. 629-633 ◽  
Author(s):  
Marco La Torre ◽  
Marco Cavallini ◽  
Giovanni Ramacciato ◽  
Giulia Cosenza ◽  
Simone Rossi del Monte ◽  
...  
Keyword(s):  
Lymph Node ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Lymph Node Ratio ◽  
Ductal Adenocarcinoma ◽  
Patient Stratification ◽  
Node Ratio

scholarly journals A systematic review of the prognostic value of lymph node ratio, number of positive nodes and total nodes examined in pancreatic ductal adenocarcinoma

2017 ◽  
Vol 99 (2) ◽  
pp. 101-106 ◽  
Author(s):  
M Elshaer ◽  
G Gravante ◽  
M Kosmin ◽  
A Riaz ◽  
A Al-Bahrani
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Lymph Node ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Ductal Adenocarcinoma ◽  
Cochrane Library ◽  
Node Ratio ◽  
The Relationship

BACKGROUND Pancreatic ductal adenocarcinoma is the most common pancreatic cancer. Five-year overall survival is currently 3.3–6.0%. The aim of this review was to evaluate the prognostic value of lymph node ratio, number of positive nodes and total nodes examined on overall survival rate following pancreatic resection. MATERIALS AND METHODS A literature search was conducted of MEDLINE, EMBASE, the Cochrane Library and Central Register of Controlled Trials and the Cochrane Database of Systematic Review databases, from January 1996 to January 2016. RESULTS Overall, 19 studies including 4,883 patients examined the relationship between lymph node ratio and overall survival. A high lymph node ratio was associated with decreased overall survival in 17 studies. A total of 12 studies examined the relationship between the number of positive nodes and overall survival, and 11 studies revealed that an increase in the number of positive nodes was associated with decreased overall survival. In 15 studies examining the relationship between the total nodes examined and overall survival, there was no association with overall survival in 12 studies. CONCLUSIONS Lymph node ratio and number of positive nodes are factors associated with overall survival in pancreatic ductal adenocarcinoma, but not total nodes examined.

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