Statin usage and cardiovascular risk among people living with HIV in the U.S. Military HIV Natural History Study

HIV Medicine ◽  
2021 ◽  
Author(s):  
Derek Larson ◽  
Seung Hyun Won ◽  
Anuradha Ganesan ◽  
Ryan C. Maves ◽  
Karl Kronmann ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Natural History ◽  
People Living With Hiv ◽  
Natural History Study ◽  
Statin Usage ◽  
Living With Hiv ◽  
The U.S

scholarly journals Impact of switching to TAF/FTC/RPV, TAF/FTC/EVG/cobi and ABC/3TC/DTG on cardiovascular risk and lipid profile in people living with HIV: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Andrea Giacomelli ◽  
Federico Conti ◽  
Laura Pezzati ◽  
Letizia Oreni ◽  
Anna Lisa Ridolfo ◽  
...  
Keyword(s):  
Body Weight ◽  
Cardiovascular Risk ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Risk Score ◽  
Rank Test ◽  
People Living With Hiv ◽  
Cholesterol Levels ◽  
Signed Rank Test ◽  
Living With Hiv

Abstract Background We aimed to assess the overall cardiovascular and metabolic effect of the switch to three different single tablet regimens (STRs) [tenofovir alafenamide/emtricitabine/rilpivirine (TAF/FTC/RPV), TAF/FTC/elvitegravir/cobi (TAF/FTC/EVG/cobi) and ABC/lamivudine/dolutegravir (ABC/3TC/DTG)] in a cohort of people living with HIV/AIDS (PLWH) under effective ART. Methods All PLWH aged above 18 years on antiretroviral treatment with an HIV-RNA < 50 cp/mL at the time of the switch to TAF/FTC/RPV, TAF/FTC/EVG/cobi and ABC/3TC/DTG were retrospectively included in the analysis. Framingham risk score modification after 12 months from the switch such as lipid profile and body weight modification were assessed. The change from baseline to 12 months in mean cardiovascular risk and body weight in each of the STR’s group were assessed by means of Wilcoxon signed-rank test whereas a mixed regression model was used to assess variation in lipid levels. Results Five-hundred and sixty PLWH were switched to an STR regimen of whom 170 (30.4%) to TAF/FTC/EVG/cobi, 191 (34.1%) to TAF/FTC/RPV and 199 (35.5%) to ABC/3TC/DTG. No difference in the Framingham cardiovascular risk score was observed after 12 months from the switch in each of the STR’s groups. No significant overtime variation in mean total cholesterol levels from baseline to 12 months was observed for PLWH switched to ABC/3TC/DTG [200 (SD 38) mg/dl vs 201 (SD 35) mg/dl; p = 0.610] whereas a significant increment was observed in PLWH switched to TAF/FTC/EVG/cobi [192 (SD 34) mg/dl vs 208 (SD 40) mg/dl; p < 0.0001] and TAF/FTC/RPV [187 (SD 34) mg/dl vs 195 (SD 35) mg/dl; p = 0.027]. In addition, a significant variation in the mean body weight from baseline to 12 months was observed in PLWH switched to TAF/FTC/EVG/cobi [72.2 (SD 13.5) kilograms vs 74.6 (SD 14.3) kilograms; p < 0.0001] and TAF/FTC/RPV [73.4 (SD 11.6) kilograms vs 75.6 (SD 11.8) kilograms; p < 0.0001] whereas no difference was observed in those switched to ABC/3TC/DTG [71.5 (SD 12.8) kilograms vs 72.1 (SD 12.6) kilograms; p = 0.478]. Conclusion No difference in the cardiovascular risk after 1 year from the switch to these STRs were observed. PLWH switched to TAF/FTC/EVG/cobi and TAF/FTC/RPV showed an increase in total cholesterol levels and body weight 12 months after the switch.

scholarly journals Managing cardiovascular risk in people living with HIV in Asia – where are we now?

HIV Medicine ◽  
2021 ◽  
Author(s):  
Jun Yong Choi ◽  
Grace Chung Yan Lui ◽  
Chia‐Te Liao ◽  
Chia‐Jui Yang
Keyword(s):  
Cardiovascular Risk ◽  
People Living With Hiv ◽  
Living With Hiv

scholarly journals Assessing Cardiovascular Risk in People Living with HIV: Current Tools and Limitations

2021 ◽  
Author(s):  
Amit C. Achhra ◽  
Asya Lyass ◽  
Leila Borowsky ◽  
Milana Bogorodskaya ◽  
Jorge Plutzky ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
People Living With Hiv ◽  
Living With Hiv

scholarly journals Hospitalizations among HIV controllers and persons with medically controlled HIV in the U.S. Military HIV Natural History Study

2016 ◽  
Vol 19 (1) ◽  
pp. 20524 ◽  
Author(s):  
Trevor A Crowell ◽  
Anuradha Ganesan ◽  
Stephen A Berry ◽  
Robert G Deiss ◽  
Brian K Agan ◽  
...  
Keyword(s):  
Natural History ◽  
Natural History Study ◽  
Hiv Controllers ◽  
The U.S

scholarly journals A Step Closer to the “Fourth 90”: A Practical Narrative Review of Diagnosis and Management of Nutritional Issues of People Living with HIV

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2047
Author(s):  
Davide Fiore Bavaro ◽  
Paola Laghetti ◽  
Mariacristina Poliseno ◽  
Nicolò De Gennaro ◽  
Francesco Di Gennaro ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Current Knowledge ◽  
Disease Stage ◽  
Oral Glucose ◽  
People Living With Hiv ◽  
Diagnosis And Management ◽  
Increased Risk ◽  
Living With Hiv

The quality of life of people living with HIV (PLWH) has remarkably increased thanks to the introduction of combined antiretroviral therapy. Still, PLWH are exposed to an increased risk of cardiovascular diseases, diabetes, chronic kidney disease, and liver disease. Hence, the purpose of this review is to summarize the current knowledge about diagnosis and nutritional management with specific indication of macro and micronutrients intake for the main comorbidities of PLWH. In fact, a prompt diagnosis and management of lifestyle behaviors are fundamental steps to reach the “fourth 90”. To achieve an early diagnosis of these comorbidities, clinicians have at their disposal algorithms such as the Framingham Score to assess cardiovascular risk; transient elastography and liver biopsy to detect NAFLD and NASH; and markers such as the oral glucose tolerance test and GFR to identify glucose impairment and renal failure, respectively. Furthermore, maintenance of ideal body weight is the goal for reducing cardiovascular risk and to improve diabetes, steatosis and fibrosis; while Mediterranean and low-carbohydrate diets are the dietetic approaches proposed for cardioprotective effects and for glycemic control, respectively. Conversely, diet management of chronic kidney disease requires different nutritional assessment, especially regarding protein intake, according to disease stage and eventually concomitant diabetes.

HIV Stigma Reduction Through Peer-Led Advocacy Training

2021 ◽  
Vol 33 (4) ◽  
pp. 303-311
Author(s):  
Susan Reif ◽  
Haley Cooper ◽  
Elena Wilson ◽  
Gina Brown ◽  
Nicole Beckwith ◽  
...  
Keyword(s):  
Well Being ◽  
Hiv Stigma ◽  
People Living With Hiv ◽  
Negative Effects ◽  
Advocacy Training ◽  
Ongoing Training ◽  
Related Stigma ◽  
Training And Support ◽  
Living With Hiv ◽  
The U.S

HIV-related stigma is pervasive in the U.S. South and has potential negative effects on health outcomes and emotional well-being, and may act as a barrier to HIV-related advocacy among people living with HIV (PLWH). This article reports on the preliminary outcomes associated with participation in an HIV advocacy training for PLWH, LEAD, that included education and skills building for reducing HIV-related stigma. Fifty-seven PLWH at four sites in the U.S. South participated in the retreat-style training and completed a survey measuring stigma and comfort engaging in advocacy prior to and after the worshop. Participation was associated with statistically significant reduction in internalized HIV stigma and increase in comfort with participation in advocacy; however, participants reported a need for ongoing training and support to further increase comfort with advocacy participation. Although more research is needed on the LEAD Workshop, it shows promise as an option for reducing HIV-related stigma among PLWH.

scholarly journals Level of agreement between frequently used cardiovascular risk calculators in people living with HIV

HIV Medicine ◽  
2019 ◽  
Vol 20 (5) ◽  
pp. 347-352 ◽  
Author(s):  
S Dhillon ◽  
CA Sabin ◽  
J Alagaratnam ◽  
E Bagkeris ◽  
FA Post ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Level Of Agreement

Progression of Subclinical Vascular Damage in People Living With HIV Is Not Predicted by Current Cardiovascular Risk Scores

2020 ◽  
Vol 83 (5) ◽  
pp. 504-512
Author(s):  
Chris J. Kapelios ◽  
Antonios A. Argyris ◽  
Athanase D. Protogerou ◽  
Ioannis Katsarolis ◽  
Aikaterini Arida ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Vascular Damage ◽  
Risk Scores ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Subclinical Vascular Damage

Abstract PO-103: Cancer mortality disparities among people living with HIV in the U.S.

2020 ◽  
Author(s):  
Sabina O. Nduaguba ◽  
Janai Poullard ◽  
Robert L. Cook ◽  
Folakemi Odedina ◽  
Almut G. Winterstein
Keyword(s):  
Cancer Mortality ◽  
People Living With Hiv ◽  
Mortality Disparities ◽  
Living With Hiv ◽  
The U.S
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