scholarly journals Urinary biomarkers of early renal injury in antiretroviral‐naïve HIV‐positive persons in Shanghai, China: comparison with the general population

HIV Medicine ◽  
2021 ◽  
Author(s):  
XQ Le ◽  
DP Liu ◽  
J Chen ◽  
ZY Gong ◽  
JN Xun ◽  
...  
Keyword(s):  
General Population ◽  
Renal Injury ◽  
Urinary Biomarkers ◽  
Hiv Positive

scholarly journals Protease Inhibitor-Associated Dyslipidemia in HIV-Infected Patients Is Strongly Influenced by the APOA5–1131T→C Gene Variation

2006 ◽  
Vol 52 (10) ◽  
pp. 1914-1919 ◽  
Author(s):  
Montse Guardiola ◽  
Raimon Ferré ◽  
Juliana Salazar ◽  
Carlos Alonso-Villaverde ◽  
Blai Coll ◽  
...  
Keyword(s):  
General Population ◽  
Protease Inhibitor ◽  
Hdl Cholesterol ◽  
Hiv Positive ◽  
Progressive Reduction ◽  
Cholesterol Ratio ◽  
Gene Variation ◽  
Highly Active ◽  
Apolipoprotein A ◽  
Apoa5 Gene

Abstract Background: Hyperlipidemia associated with the protease inhibitor (PI) component of highly active antiretrovial treatment can lead to accelerated atherosclerosis. The apolipoprotein A-V (APOA5) gene, which affects VLDL production and lipolysis, may play a role in PI-induced hyperlipidemia, particularly in individuals with the APOA5–1131T→C genotype. Methods: We measured lipoprotein changes in HIV-positive patients (n = 229) who had been followed for 5 years. For statistical analyses, we segregated the patients with respect to PI treatment and APOA5–1131T→C genotype. Results: The frequency of the C allele was 0.08, similar to that in the general population. We found a strong effect of the APOA5–1131T→C genotype among patients receiving PIs. Carriers of the C allele had consistently increased mean (SD) triglyceride concentrations compared with noncarriers after 1 year [2.11 (1.62) vs 3.71 (4.27) mmol/L; P = 0.009], 2 years [2.48 (2.09) vs 4.02 (4.05) mmol/L, P = 0.050], 3 years [2.32 (1.71) vs 4.13 (4.26) mmol/L; P = 0.013], 4 years [2.90 (2.95) vs 5.35 (7.12) mmol/L; P was not significant], and 5 years [4.25 (5.58) vs 9.23 (9.63) mmol/L; P was not significant]. We observed the same effect on total cholesterol concentrations: after 1 year [4.93 (1.31) vs 5.87 (1.66) mmol/L; P = 0.006], 2 years [5.03 (1.12) vs 6.42 (2.48) mmol/L; P = 0.001], 3 years [5.11 (1.17) vs 6.38 (2.43) mmol/L; P = 0.009], 4 years [5.49 (1.71) vs 6.78 (3.03) mmol/L; P was not significant], and 5 years [5.56 (1.75) vs 7.90 (3.60) mmol/L; P was not significant]. HDL cholesterol showed a progressive reduction, leading to a considerably higher cholesterol/HDL cholesterol ratio after 3 years. Conclusion: Variability in the APOA5 gene predisposes patients with HIV, particularly those treated with PI, to severe hyperlipidemia.

328 Insomnia in older HIV patients: a systematic review

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A131-A131
Author(s):  
Igor Freire ◽  
Miguel Meira e Cruz ◽  
Cristina Salles
Keyword(s):  
Systematic Review ◽  
General Population ◽  
Animal Studies ◽  
Advanced Age ◽  
Cochrane Library ◽  
Hiv Positive ◽  
Sleep Difficulty ◽  
Cross Sectional ◽  
Previous Diagnosis ◽  
Worse Prognosis

Abstract Introduction Insomnia is a common sleep disorder in elderly. Although the HIV-positive population have a similar life expectancy when compared to the general population, some factors may interact with immunity conditions and therefore contribute to a worse prognosis. Little is known however, about the frequency of insomnia in older HIV-positive patients. OBJECTIVE: To systematic review the prevalence of insomnia in older HIV-positive patients. Methods Systematic Review. Several databases were consulted (MEDLINE-PubMed, Embase, Cochrane Library, CINAHL, Web of Science, Scopus, SciELO, LILACS, and VHL) and manual searches were performed. The terms used for the search were related to prevalence, HIV, insomnia, and advanced age. The inclusion criteria were: cross-sectional, cohort, and longitudinal studies. The accepted data were in patients with the previous diagnosis of HIV in advanced age, those over 50 years; studies that report the frequency of insomnia or insomnia symptoms (accepted symptoms: difficulty in starting sleep, difficulty in maintaining sleep, multiple awakenings during sleep and early awakening). The criteria for exclusion were: clinical trials, animal studies, letters, abstracts, conference proceedings, studies with other sleep scales that did not include insomnia. Results There were 2805 publications found in the database and a further 10 articles were included manually. Of this total, four were included in this review, resulting in a total of 2,227 participants. The prevalence of insomnia in HIV-positive patients over 50 years varied from 12.5% to 76.5%. Conclusion The frequency of insomnia was higher in the profile of the population studied than in the general population. This should be clinically relevant in order to adequately treat and impact on the prognosis of those patient. Support (if any):

scholarly journals Economic Burden of HIV/AIDS upon Households in Nepal: A Critical Review

2015 ◽  
Vol 5 (3) ◽  
pp. 502-510 ◽  
Author(s):  
Ak Narayan Poudel ◽  
David Newlands ◽  
Padam Simkhada
Keyword(s):  
General Population ◽  
Economic Burden ◽  
Hiv Positive ◽  
Knowledge Gap ◽  
Policy Recommendations ◽  
Household Level ◽  
Travel Costs ◽  
Working Age ◽  
Awareness Level ◽  
Hiv Aids

Thousands of people are infected with HIV/AIDS in Nepal and most of them are adults of working age. Therefore, HIV/AIDS is a big burden in Nepal. This review was conducted to find the existing knowledge gap about the economic burden of HIV/AIDS at the household level in Nepal, the extent of economic burden exerted by the disease, and to provide policy recommendations. It is concluded that there was a considerable knowledge gap about the issue, and the economic burden exerted by HIV/AIDS was big enough to push the affected households into poverty. It is suggested that more studies need to be conducted to fill the knowledge gap. Similarly, Government of Nepal and other organisations working in the field of HIV/AIDS need to provide economic supports (e.g.- support for travel costs) to the HIV positive people and need to increase the awareness level among general population for reducing stigma and discrimination, and reducing economic burden on them.

All-cause and liver-related mortality in HIV positive subjects compared to the general population: Differences by HCV co-infection

2012 ◽  
Vol 57 (4) ◽  
pp. 743-751 ◽  
Author(s):  
Victoria Hernando ◽  
Santiago Perez-Cachafeiro ◽  
Charlotte Lewden ◽  
Juan Gonzalez ◽  
Ferran Segura ◽  
...  
Keyword(s):  
General Population ◽  
Hiv Positive ◽  
Population Differences ◽  
Related Mortality

Urinary biomarkers of renal injury in the hexachloro-1:3-butadiene treated male Hanover Wistar rat; a dose-response study at low dose levels

Toxicology ◽  
2011 ◽  
Vol 290 (2-3) ◽  
pp. 138-139
Author(s):  
Ines Pereira ◽  
Aubrey Swain ◽  
John Turton ◽  
Cheryl L. Scudamore ◽  
David Maguire ◽  
...  
Keyword(s):  
Dose Response ◽  
Renal Injury ◽  
Low Dose ◽  
Wistar Rat ◽  
Urinary Biomarkers ◽  
Treated Male ◽  
Dose Response Study ◽  
Dose Levels

A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function

2010 ◽  
Vol 28 (5) ◽  
pp. 486-494 ◽  
Author(s):  
Josef S Ozer ◽  
Frank Dieterle ◽  
Sean Troth ◽  
Elias Perentes ◽  
André Cordier ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Injury ◽  
Serum Marker ◽  
Urinary Biomarkers

scholarly journals Overall and cause-specific mortality in HIV-positive subjects compared to the general population

2014 ◽  
Vol 17 ◽  
pp. 19711 ◽  
Author(s):  
Belen Alejos ◽  
Victoria Hernando ◽  
Jose López-Aldeguer ◽  
Ferrán Segura ◽  
José Antonio Oteo ◽  
...  
Keyword(s):  
General Population ◽  
Hiv Positive ◽  
Specific Mortality

scholarly journals Carpal tunnel syndrome in HIV-positive patients coinfected with HCV

Reumatismo ◽  
2017 ◽  
Vol 69 (4) ◽  
pp. 164
Author(s):  
A. Mastroianni ◽  
F. Allegrini ◽  
S. Nardi ◽  
D. Donatucci ◽  
F. Girelli ◽  
...  
Keyword(s):  
General Population ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Hiv Disease ◽  
Age Related ◽  
Rheumatic Manifestations ◽  
Wide Range ◽  
Inflammatory State ◽  
Advanced Hiv Disease ◽  
Living With Hiv

A wide range of rheumatic and peripheral nervous system disorders may develop in patients with HIV infection, leading to pain, sensory symptoms, and muscle weakness. Over the past three decades, the progress in management of HIV disease with anti-retroviral therapy (ART) has resulted in increased life expectancy for people living with HIV disease. With this new chronicity of the disease has a constellation of chronic musculoskeletal, orthopaedic and rheumatic manifestations has emerged, as potential complications of the disease itself and/or the results of ART treatment regimen and/or because of expected age-related symptoms/manifestations. The incidence of CTS in the general population is around 3.8% with clinical examination and, when electroneuromyography is used, it is 2.7%. In the HIV-positive population, the incidence is very close to that of the general population. The aim of this study was to evaluate the incidence of CTS and to identify factors influencing the development of CTS in HIV-infected patients attending our clinic. This syndrome has been associated with advanced HIV disease and the use of ART possibly due to an increased inflammatory state and the presence of concurrent HCV infection.

scholarly journals Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3187
Author(s):  
Claudia Vanetti ◽  
Daria Trabattoni ◽  
Marta Stracuzzi ◽  
Antonella Amendola ◽  
Clara Fappani ◽  
...  
Keyword(s):  
Immune Response ◽  
General Population ◽  
Crucial Role ◽  
Rna Virus ◽  
Hiv Positive ◽  
Specific Antibodies ◽  
Increased Risk ◽  
Set Up

While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in the general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected in a cohort of HIV-infected young individuals during the first wave of COVID-19 pandemic. SARS-CoV-2 RNA, virus-specific antibodies, as well as the expression of factors involved in the anti-viral immune response were analyzed. Moreover, we set up an in vitro coinfection assay to study the mechanisms correlated to the coinfection process. Our results did not show any increased risk of severe COVID-19 in HIV-positive young individuals. In those subjects who contracted SARS-CoV-2 infection, an increase in IL-10 expression and production was observed. Furthermore, in the in vitro coinfection assay, we revealed a reduction in SARS-CoV-2 replication associated to an upregulation of IL-10. We speculate that IL-10 could play a crucial role in the course of SARS-CoV-2 infection in HIV-positive individuals. These results might help defining clinical management of HIV/SARS-CoV-2 co-infected young individuals, or putative indications for vaccination schedules in this population.

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