Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations

HIV Medicine ◽  
2021 ◽  
Author(s):  
M Saumoy ◽  
S Di Yacovo ◽  
S Pérez ◽  
JL Sánchez‐Quesada ◽  
JM Valdivielso ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Carotid Atherosclerosis ◽  
Hiv Patients ◽  
Healthy Sample

scholarly journals Burden of cardiovascular risk factors in stable HIV patients aged 50 years old and above

2020 ◽  
Vol 101 ◽  
pp. 284-285
Author(s):  
K.H. Tay ◽  
S. Chidambaram ◽  
L.H. Benedict Sim ◽  
K.C. Christopher Lee
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Hiv Patients

scholarly journals Hypertriglyceridemia and Waist Circumference Predict Cardiovascular Risk among HIV Patients: A Cross-Sectional Study

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e25032 ◽  
Author(s):  
Peter M. Janiszewski ◽  
Robert Ross ◽  
Jean-Pierre Despres ◽  
Isabelle Lemieux ◽  
Gabriella Orlando ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Waist Circumference ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Hiv Patients ◽  
Cross Sectional

scholarly journals Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study

2010 ◽  
Vol 31 (14) ◽  
pp. 1745-1751 ◽  
Author(s):  
M. Juonala ◽  
J. S. A. Viikari ◽  
M. Kahonen ◽  
L. Taittonen ◽  
T. Laitinen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Cardiovascular Risk ◽  
Carotid Atherosclerosis ◽  
Life Time ◽  
Young Finns Study

scholarly journals Diabetes and Hypertension among Patients Receiving Antiretroviral Treatment Since 1998 in Senegal: Prevalence and Associated Factors

ISRN AIDS ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Assane Diouf ◽  
Amandine Cournil ◽  
Khadidiatou Ba-Fall ◽  
Ndèye Fatou Ngom-Guèye ◽  
Sabrina Eymard-Duvernay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Antiretroviral Treatment ◽  
Cross Sectional Study ◽  
Older Age ◽  
World Health ◽  
Resource Constrained ◽  
Hiv Patients ◽  
Cross Sectional

Cardiovascular risk factors in people on antiretroviral treatment (ART) are poorly documented in resource-constrained settings. A cross-sectional study was conducted in 2009 to assess prevalence of diabetes and hypertension in a sample of 242 HIV-infected patients who had initiated ART between 1998 and 2002 in Dakar, Senegal (ANRS 1215 observational cohort). World Health Organization (WHO) criteria were applied to diagnose diabetes and hypertension. Multiple logistic regressions were used to identify factors associated with diabetes and hypertension. Patients had a median age of 46 years and had received ART for a median duration of about 9 years. 14.5% had diabetes and 28.1% had hypertension. Long duration of ART (≥119 months), older age, higher body mass index (BMI), and higher levels of total cholesterol were associated with higher risks of diabetes. Older age, higher BMI at ART initiation, and higher levels of triglycerides were associated with higher risk of hypertension. This study shows that diabetes and hypertension were frequent in these Senegalese HIV patients on ART. It confirms the association between duration of ART and diabetes and highlights the need to implement programs for prevention of cardiovascular risk factors in HIV patients from resource-constrained settings.

Uric acid and uric acid/creatinine ratio and their correlations with the hemorheological determinants in subjects with subclinical carotid atherosclerosis

2022 ◽  
pp. 1-9
Author(s):  
Gregorio Caimi ◽  
Caterina Urso ◽  
Salvatore Brucculeri ◽  
Corrado Amato ◽  
Rosalia Lo Presti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Serum Uric Acid ◽  
Carotid Atherosclerosis ◽  
Erythrocyte Aggregation ◽  
Creatinine Ratio ◽  
Serum Uric Acid Concentration

BACKGROUND AND OBJECTIVE: we have examined the concentration of serum uric acid and the serum uric acid/creatinine ratio as well as their correlations with the main determinants of the hemorheological profile in a group of subjects with subclinical carotid atherosclerosis. METHODS: we evaluated the concentration of serum uric acid and the serum uric acid/creatine ratio in 43 men and 57 women [median age 66.00 (25)] with subclinical carotid atherosclerosis, subsequently divided according to the number of traditional cardiovascular risk factors and to the insulin resistance degree. RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree. In the whole group and in the subgroups of subclinical carotid atherosclerosis subjects, serum uric acid and serum uric acid/creatinine ratio show significant correlation, besides with whole blood viscosity, with plasma viscosity and erythrocyte aggregation. The influence of the serum uric acid on the erythrocyte aggregability that is a part of the erythrocyte aggregation is to ascribe to the action carried out by serum uric acid on the erythrocyte zeta potential. CONCLUSIONS: it is reasonable to think that the treatment of the asymptomatic or symptomatic hyperuricemia with the urate-lowering therapy that reduces the serum uric acid concentration may reflect on the hemorheological profile which role on the atherosclerotic cardiovascular disease is well known.

Alcohol consumption and carotid atherosclerosis in China: the Cardiovascular Risk Survey

2011 ◽  
Vol 19 (3) ◽  
pp. 314-321 ◽  
Author(s):  
Xiang Xie ◽  
Yi-Tong Ma ◽  
Yi-Ning Yang ◽  
Zhen-Yan Fu ◽  
Xiang Ma ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Alcohol Consumption ◽  
Carotid Artery ◽  
Alcohol Intake ◽  
Carotid Atherosclerosis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Moderate Drinking ◽  
Carotid Plaques ◽  
Uygur Population

Aim: The relationship between alcohol consumption and carotid atherosclerosis has been reported in some epidemiological studies, but the results were conflicting. We investigated the association between alcohol intake and carotid atherosclerosis in the Han, Uygur, and Kazakh populations in Xinjiang in western China. Methods and results: The study population sample comprised 13,037 Chinese people (5277 Han, 4572 Uygur, and 3188 Kazakh) aged ≥35 years who participated in a cardiovascular risk survey between June 2007 and March 2010. Daily consumption of alcohol was determined by the number and frequency of alcoholic beverages consumed. Carotid-artery parameters, including common carotid artery intima–media thickness (CCA–IMT) and carotid plaques were measured using high-resolution B-mode ultrasonography. In the Han and Kazakh populations, CCA–IMT as a function of alcohol consumption was depicted as a J-shaped curve with a nadir for the alcohol-intake category of 20–29.9 g/day; In the Uygur population, a similar curve with a nadir of 30–49.9 g/day was observed. With respect to the prevalence of carotid plaques, we also observed similar curves in the Han and Kazakh populations, but not in the Uygur population. After adjustment for age, sex, blood pressure, body mass index, and smoking status, as well as levels of glucose, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol, the J-shaped curves remained. Conclusions: Our results indicated that alcohol consumption was associated with carotid atherosclerosis and that moderate drinking had an inverse association with carotid atherosclerosis. However, the definition of moderate drinking could be different in Han, Uygur, and Kazakh populations.

Metabolic Syndrome and Cardiovascular Risk in HIV-Infected Patients with Lipodystrophy

2007 ◽  
Vol 20 (3) ◽  
pp. 519-527 ◽  
Author(s):  
K. Falasca ◽  
C. Ucciferri ◽  
L. Manzoli ◽  
P. Mancino ◽  
E. Pizzigallo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Antiviral Therapy ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Hiv Patients ◽  
Cross Sectional ◽  
Adjusted Risk ◽  
The Metabolic Syndrome ◽  
Independent Association

In this cross-sectional study, we evaluate potential predictors of Metabolic Syndrome (MS) in a group of 54 Caucasian chronically HIV-infected patients with lipodystrophy. According to ATP-III criteria, 22 patients were affected by MS and 32 were not. The mean age of the sample was 41.2 ± 8.6 years, and most patients were males (74.1%); the two groups were homogeneous for gender, age, viro-immunologic status and the duration of antiviral therapy. The independent association between MS and several factors including demographic characteristics, type of highly-active antiviral therapy (HAART), viro-immunologic response, common cardiovascular risk factors (including Framingham scores), and selected cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10 and IL-18), was investigated using stepwise forward logistic regression. At multivariate analysis, the only independent predictors of the metabolic syndrome were triglycerides and IL-18. A10 mg/dL increase in triglycerides corresponds to an adjusted risk ratio for MS of 1.11 (95% IC: 1.04–1.19); and patients in the top tertile of IL-18 (those with IL-18 ≥ 530 pg/L) had more than three times the likelihood of MS, as compared to the bottom and medium fertiles of IL-18 (patients with IL-18 < 530 pg/L). This relationship was not attenuated by the inclusion of any other variable in the multivariate model. However, the association between metabolic syndrome and IL-18 is no longer significant when IL-18 is treated as a continuous variable (trend p = 0.087). Our results on HIV patients with lipodystrophy confirm previous findings on a strong independent association between IL-18 and MS in the general population. Further research is needed to clarify the mechanism of this association and its role in the development of cardiovascular disease in HIV patients.

Cardiac autonomic reactivity and recovery in predicting carotid atherosclerosis: The cardiovascular risk in young finns study.

2007 ◽  
Vol 26 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Tarja Heponiemi ◽  
Marko Elovainio ◽  
Laura Pulkki ◽  
Sampsa Puttonen ◽  
Olli Raitakari ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Carotid Atherosclerosis ◽  
Autonomic Reactivity ◽  
Young Finns Study

scholarly journals Oscillometrically Measured Aortic Pulse Wave Velocity Reveals Asymptomatic Carotid Atherosclerosis in a Middle-Aged, Apparently Healthy Population

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Renáta Marietta Böcskei ◽  
Béla Benczúr ◽  
Veronika Müller ◽  
András Bikov ◽  
Andrea Székely ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Odds Ratio ◽  
Carotid Atherosclerosis ◽  
Pulse Wave ◽  
Aortic Pulse Wave Velocity ◽  
Middle Aged ◽  
Asymptomatic Carotid ◽  
Aged Subjects ◽  
Apparently Healthy

Background. Asymptomatic atherosclerosis is a common entity even at young age. Studies have suggested a strong relationship between increased arterial stiffness and asymptomatic carotid atherosclerosis (ACA) in general population, particularly in those with high cardiovascular risk, but no data exist from a younger population free from recognized cardiovascular disease. Hypothesis. We hypothesized there is an association between ACA and aortic pulse wave velocity (PWVao) in middle-aged, apparently healthy, normotensive population to reveal increased cardiovascular risk. Methods. We examined the relationship between ACA and PWVao in 236 apparently healthy, asymptomatic, normotensive, middle-aged subjects (age 47 ± 8 years; 52% women). PWVao was measured with the oscillometric method (Arteriograph). ACA was assessed by carotid artery ultrasonography. Results. ACA was present in 51 subjects. Subjects with ACA were older (p<0.009), more likely to be smokers (p<0.001), and had higher systolic blood pressure (SBP, 128 ± 9 vs. 125 ± 10 mmHg, p=0.048) and PWVao (9.3 ± 1.6 vs. 7.9 ± 1.3 m/s, p<0.001) than subjects without ACA. In a stepwise logistic regression analysis, only PWVao (odds ratio: 1.88, p<0.001), smoking habit (odds ratio 3.79, p=0.003), systolic blood pressure (odds ratio 1.05, p=0.046), and diastolic blood pressure (odds ratio: 0.94, p=0.038) were independently associated with ACA. PWVao >8.3 m/s identified ACA with a 71% sensitivity, 65% specificity, 36% positive and 89% negative predictive value, 2.04 relative risk, and 4.54 odds ratio, respectively. Conclusions. PWVao measured by the Arteriograph proved to be an independent marker of ACA. Our study may reveal high CV risk, detected as increased PWVao, which according to our study is related in a very high probability to asymptomatic carotid atherosclerosis in apparently healthy, young, and middle-aged subjects.

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