scholarly journals Testosterone use and shorter electrocardiographic QT interval duration in men living with and without HIV

HIV Medicine ◽  
2020 ◽  
Author(s):  
PG Hiremath ◽  
F Bhondoekhan ◽  
SA Haberlen ◽  
H Ashikaga ◽  
FJ Palella ◽  
...  
Keyword(s):  
Qt Interval ◽  
Interval Duration ◽  
Qt Interval Duration

scholarly journals Coffee, Alcohol, Smoking, Physical Activity and QT Interval Duration: Results from the Third National Health and Nutrition Examination Survey

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17584 ◽  
Author(s):  
Yiyi Zhang ◽  
Wendy S. Post ◽  
Darshan Dalal ◽  
Elena Blasco-Colmenares ◽  
Gordon F. Tomaselli ◽  
...  
Keyword(s):  
Physical Activity ◽  
National Health ◽  
Qt Interval ◽  
Nutrition Examination Survey ◽  
Interval Duration ◽  
The Third ◽  
Health And Nutrition ◽  
Qt Interval Duration

scholarly journals Complex Influence of Gonadotropins and Sex Steroid Hormones on QT Interval Duration

2016 ◽  
Vol 101 (7) ◽  
pp. 2776-2784 ◽  
Author(s):  
Guillaume Abehsira ◽  
Anne Bachelot ◽  
Fabio Badilini ◽  
Laurence Koehl ◽  
Martine Lebot ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Qt Interval ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Interval Duration ◽  
Qt Interval Duration ◽  
Complex Influence

Abstract 2924: Association of NOS1AP Genetic Variants with QT Interval Duration in Families from the Diabetes Heart Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Allison B Lehtinen ◽  
Christopher Newton-Cheh ◽  
Julie T Ziegler ◽  
Carl D Langefeld ◽  
Barry I Freedman ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Qt Interval ◽  
Genetic Model ◽  
Additive Model ◽  
Adaptor Protein ◽  
European Ancestry ◽  
Nucleotide Polymorphisms ◽  
Interval Duration ◽  
Common Genetic Variants ◽  
Qt Interval Duration

Background: Prolongation of the electrocardiographic QT interval is a risk factor for sudden cardiac death (SCD) in unselected samples as well as in post-myocardial infarction patients or those with diabetes. Common genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene have been reported to be associated with QT interval duration in individuals of European ancestry. We sought to replicate the association of NOS1AP variants with QT interval duration in pedigrees enriched for type 2 diabetes mellitus (T2DM). Methods and Results: Two single nucleotide polymorphisms (SNPs) in the NOS1AP gene, rs10494366 and rs10918594, were genotyped in a collection of 937 European Americans (EAs) and 177 African Americans (AAs) in 450 pedigrees containing at least two siblings with T2DM. An additive genetic model was tested for each SNP in ancestry-specific analyses using SOLAR in the total sample and in the diabetic subset (EA n=778, AA n=159), with and without exclusion of QT-altering medications. In the EA individuals, rs10494366 minor allele homozygotes had an 8.9 msec longer mean QT interval compared to major homozygotes (additive model p=4.4x10 -3 ); rs10918594 minor homozygotes had a 12.9 msec longer mean QT interval compared to major homozygotes (p=9.9x10 -5 ). Excluding users of QT-altering medications in the diabetic-only EA sample (n=514) strengthened the association despite the reduction in sample size (20.6 msec difference, p=2.0x10 -5 ; 23.4 msec difference, p=8.9x10 -7 , respectively). No association between the NOS1AP SNPs and QT interval duration was observed in the limited number of AA individuals examined. Conclusions: Two NOS1AP SNPs are strongly associated with QT interval duration in a predominately diabetic EA sample. Stronger effects of NOS1AP variants in diabetic individuals compared to previously reported unselected samples suggest that this patient subset may be particularly susceptible to genetic variants that influence myocardial depolarization and repolarization as manifest in the QT interval.

Physical Activity, BMI and Smoking History Affect QT Interval Duration in Cardiac Patients

2014 ◽  
Vol 25 (1) ◽  
pp. 4
Author(s):  
C. J. Brahler ◽  
H. Merriman ◽  
S. Price ◽  
M. Duncan ◽  
A. Pertner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Qt Interval ◽  
Cardiac Patients ◽  
Smoking History ◽  
Interval Duration ◽  
Qt Interval Duration
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