Antiretroviral therapy and the risk of sexual transmission of HIV: a systematic review and meta‐analysis

HIV Medicine ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 349-357
Author(s):  
M Davari ◽  
HB Giwa ◽  
A Nabizade ◽  
F Taheri ◽  
A Giwa
Keyword(s):  
Systematic Review ◽  
Antiretroviral Therapy ◽  
Meta Analysis ◽  
Sexual Transmission ◽  
Sexual Transmission Of Hiv

Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis

AIDS ◽  
2009 ◽  
Vol 23 (11) ◽  
pp. 1397-1404 ◽  
Author(s):  
Suzanna Attia ◽  
Matthias Egger ◽  
Monika Müller ◽  
Marcel Zwahlen ◽  
Nicola Low
Keyword(s):  
Systematic Review ◽  
Viral Load ◽  
Antiretroviral Therapy ◽  
Meta Analysis ◽  
Sexual Transmission ◽  
Sexual Transmission Of Hiv

scholarly journals Incidence of Herpes Zoster in HIV-Infected Patients Undergoing Antiretroviral Therapy: A Systematic Review and Meta-analysis

2021 ◽  
Vol 10 (11) ◽  
pp. 2300
Author(s):  
Han-Chang Ku ◽  
Yi-Tseng Tsai ◽  
Sriyani-Padmalatha Konara-Mudiyanselage ◽  
Yi-Lin Wu ◽  
Tsung Yu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herpes Zoster ◽  
Antiretroviral Therapy ◽  
Random Effects ◽  
Meta Analysis ◽  
People Living With Hiv ◽  
Funnel Plots ◽  
Sex With Men ◽  
Treat All ◽  
Living With Hiv

The incidence of herpes zoster (HZ) in patients infected with HIV is higher than that of the general population. However, the incidence of HZ in HIV patients receiving antiretroviral therapy (ART) remains unclear. This meta-analysis aimed to estimate the pooled incidence rate and risk factors for HZ in the post-ART era. We identified studies assessing the incidence of HZ in the post-ART era between 1 January 2000 and 28 February 2021, from four databases. Pooled risk ratios were calculated from 11 articles using a random-effects model. The heterogeneity of the included trials was evaluated by visually inspecting funnel plots, performing random-effects meta-regression and using I2 statistics. Of the 2111 studies screened, we identified 11 studies that were eligible for final inclusion in the systematic review and 8 studies that were eligible for a meta-analysis. The pooled incidence of HZ in the post-ART era (after the introduction of ART in 1997) was 2.30 (95% confidence interval (CI): 1.56–3.05) per 100 person years (PYs). The risks of incidence of HZ among people living with HIV included male sex (AOR: 4.35 (95% CI: 054–2.41)), men who have sex with men (AOR: 1.21 (95% CI: −0.76–1.13)), CD4 count < 200 cells/μL (AOR: 11.59 (95% CI: 0.53–4.38)) and not receiving ART (AOR: 2.89 (95% CI: −0.44–2.56)). The incidence of HZ is substantially lower among HIV infected patients receiving ART than those not receiving ART. Initiating ART immediately after diagnosis to treat all HIV-positive individuals is crucial to minimize the disease burden of HZ.

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